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Gene Review

cld  -  combined lipase deficiency

Mus musculus

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Disease relevance of cld


High impact information on cld


Biological context of cld


Anatomical context of cld


Associations of cld with chemical compounds


Other interactions of cld

  • Thus, the CLD mutation allows secretion of inactive HL by liver and adrenals [6].

Analytical, diagnostic and therapeutic context of cld


  1. Naturally occurring mutations in mice affecting lipid transport and metabolism. Reue, K., Doolittle, M.H. J. Lipid Res. (1996) [Pubmed]
  2. Combined lipase deficiency (cld): a lethal mutation on chromosome 17 of the mouse. Paterniti, J.R., Brown, W.V., Ginsberg, H.N., Artzt, K. Science (1983) [Pubmed]
  3. Combined lipase deficiency in the mouse. Evidence of impaired lipase processing and secretion. Davis, R.C., Ben-Zeev, O., Martin, D., Doolittle, M.H. J. Biol. Chem. (1990) [Pubmed]
  4. Synthesis of inactive nonsecretable high mannose-type lipoprotein lipase by cultured brown adipocytes of combined lipase-deficient cld/cld mice. Masuno, H., Blanchette-Mackie, E.J., Chernick, S.S., Scow, R.O. J. Biol. Chem. (1990) [Pubmed]
  5. Differential effect of combined lipase deficiency (cld/cld) on human hepatic lipase and lipoprotein lipase secretion. Boedeker, J.C., Doolittle, M.H., White, A.L. J. Lipid Res. (2001) [Pubmed]
  6. Combined lipase deficiency (cld/cld) in mice affects differently post-translational processing of lipoprotein lipase, hepatic lipase and pancreatic lipase. Scow, R.O., Schultz, C.J., Park, J.W., Blanchette-Mackie, E.J. Chem. Phys. Lipids (1998) [Pubmed]
  7. Combined lipase deficiency (cld/cld) in mice. Demonstration that an inactive form of lipoprotein lipase is synthesized. Olivecrona, T., Chernick, S.S., Bengtsson-Olivecrona, G., Paterniti, J.R., Brown, W.V., Scow, R.O. J. Biol. Chem. (1985) [Pubmed]
  8. Lipoprotein lipase mRNA in neonatal and adult mouse tissues: comparison of normal and combined lipase deficiency (cld) mice assessed by in situ hybridization. Yacoub, L.K., Vanni, T.M., Goldberg, I.J. J. Lipid Res. (1990) [Pubmed]
  9. Adrenal and liver in normal and cld/cld mice synthesize and secrete hepatic lipase, but the lipase is inactive in cld/cld mice. Schultz, C.J., Blanchette-Mackie, E.J., Scow, R.O. J. Lipid Res. (2000) [Pubmed]
  10. Effect of combined lipase deficiency (cld/cld) on hepatic and lipoprotein lipase activities in liver and plasma of newborn mice. Olivecrona, T., Bengtsson-Olivecrona, G., Chernick, S.S., Scow, R.O. Biochim. Biophys. Acta (1986) [Pubmed]
  11. Brefeldin A enables synthesis of active lipoprotein lipase in cld/cld and castanospermine-treated mouse brown adipocytes via translocation of Golgi components to endoplasmic reticulum. Park, J.W., Blanchette-Mackie, E.J., Scow, R.O. Biochem. J. (1996) [Pubmed]
  12. Expression of lipoprotein lipase gene in combined lipase deficiency. Oka, K., Yuan, J.G., Senda, M., Masibay, A.S., Qasba, P.K., Masuno, H., Scow, R.O., Paterniti, J.R., Brown, W.V., Oasba, P.K. Biochim. Biophys. Acta (1989) [Pubmed]
  13. Molecular cloning of mouse hepatic triacylglycerol lipase: gene expression in combined lipase-deficient (cld/cld) mice. Oka, K., Nakano, T., Tkalcevic, G.T., Scow, R.O., Brown, W.V. Biochim. Biophys. Acta (1991) [Pubmed]
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