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Gene Review

Cpd  -  carboxypeptidase D

Mus musculus

Synonyms: AA960140, AW322530, Carboxypeptidase D, D830034L15Rik, Metallocarboxypeptidase D, ...
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Disease relevance of Cpd

  • Based on their sizes, prosthetic groups, and locations in virions, these proteins were designated gp180/E2, gp90/E2, pp54/N, gp26.5/E1, gp25.5/E1, p24/E1, p22/X, and p14.5/Y [1].

High impact information on Cpd

  • After ligand-induced receptor patching and/or capping, the amount of gp 180 in the membrane-associated cytoskeleton fraction increases in direct proportion to the percentage of patched/capped cells [2].
  • The purposes of this study were to examine the Cys residues of the transmembrane domain of metallocarboxypeptidase D (CPD) that could be a target for palmitoylation and to clarify the function of this modification [3].
  • Cdc25A inhibitor Cpd 5, a vitamin K analog, inhibited Cdc25A activity in the Cdc25A-EGFR immunocomplex and consequently caused prolonged EGFR tyrosine phosphorylation [4].
  • A second major finding of the present study is that a soluble truncated form of CPD is secreted mainly via the constitutive pathway in AtT-20 cells, indicating that the lumenal domain does not contain signals for the sorting of CPD to mature secretory granules [5].
  • To investigate the regions of the gp180 tail involved with TGN retention and intracellular trafficking, gp180 and various deletion and point mutations were expressed in the AtT-20 mouse pituitary corticotroph cell line [6].

Biological context of Cpd


Anatomical context of Cpd


Associations of Cpd with chemical compounds

  • Taken together, these data suggest that CPE is completely inactive in the Cpefat/Cpefat mice, and that all of the CPE-like activity is due to other carboxypeptidases such as carboxypeptidase D. Levels of Leu-enkephalin in Cpefat/Cpefat mouse brain are approximately 5-fold lower than those in control brain [11].
  • In the presence of 2-mercaptoethanol, three major glycopolypeptides, gp180, gp69, gp25 (as a group of similar species) and one major non-glycosylated polypeptide p58 were detected [12].

Regulatory relationships of Cpd


Other interactions of Cpd


Analytical, diagnostic and therapeutic context of Cpd


  1. Viral protein synthesis in mouse hepatitis virus strain A59-infected cells: effect of tunicamycin. Rottier, P.J., Horzinek, M.C., van der Zeijst, B.A. J. Virol. (1981) [Pubmed]
  2. A T-lymphoma transmembrane glycoprotein (gp180) is linked to the cytoskeletal protein, fodrin. Bourguignon, L.Y., Suchard, S.J., Nagpal, M.L., Glenney, J.R. J. Cell Biol. (1985) [Pubmed]
  3. Palmitoylation of carboxypeptidase D. Implications for intracellular trafficking. Kalinina, E.V., Fricker, L.D. J. Biol. Chem. (2003) [Pubmed]
  4. Identification of epidermal growth factor receptor as a target of Cdc25A protein phosphatase. Wang, Z., Wang, M., Lazo, J.S., Carr, B.I. J. Biol. Chem. (2002) [Pubmed]
  5. Localization of metallocarboxypeptidase D in AtT-20 cells. Potential role in prohormone processing. Varlamov, O., Eng, F.J., Novikova, E.G., Fricker, L.D. J. Biol. Chem. (1999) [Pubmed]
  6. Sequences within the cytoplasmic domain of gp180/carboxypeptidase D mediate localization to the trans-Golgi network. Eng, F.J., Varlamov, O., Fricker, L.D. Mol. Biol. Cell (1999) [Pubmed]
  7. Carboxypeptidase E in the mouse placenta. Singh, U., Yu, Y., Kalinina, E., Konno, T., Sun, T., Ohta, H., Wakayama, T., Soares, M.J., Hemberger, M., Fundele, R.H. Differentiation (2006) [Pubmed]
  8. Cloning, functional expression, and chromosomal localization of the human and mouse gp180-carboxypeptidase D-like enzyme. Ishikawa, T., Murakami, K., Kido, Y., Ohnishi, S., Yazaki, Y., Harada, F., Kuroki, K. Gene (1998) [Pubmed]
  9. Chromosomal localization of the genes for human carboxypeptidase D (CPD) and the active 50-kilodalton subunit of human carboxypeptidase N (CPN1). Riley, D.A., Tan, F., Miletich, D.J., Skidgel, R.A. Genomics (1998) [Pubmed]
  10. Synaptic vesicle and synaptic membrane glycoproteins during pre- and postnatal development of mouse cerebral cortex, cerebellum and spinal cord. Mayanil, C.S., Knepper, P.A. Dev. Neurosci. (1993) [Pubmed]
  11. Carboxypeptidase E activity is deficient in mice with the fat mutation. Effect on peptide processing. Fricker, L.D., Berman, Y.L., Leiter, E.H., Devi, L.A. J. Biol. Chem. (1996) [Pubmed]
  12. Structural polypeptides of the murine coronavirus DVIM. Sugiyama, K., Ishikawa, R., Fukuhara, N. Arch. Virol. (1986) [Pubmed]
  13. Protein phosphatase 2A binds to the cytoplasmic tail of carboxypeptidase D and regulates post-trans-Golgi network trafficking. Varlamov, O., Kalinina, E., Che, F.Y., Fricker, L.D. J. Cell. Sci. (2001) [Pubmed]
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