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Gene Review

Dld  -  dihydrolipoamide dehydrogenase

Mus musculus

Synonyms: AI315664, AI746344, Dihydrolipoamide dehydrogenase, Dihydrolipoyl dehydrogenase, mitochondrial, branched chain alpha-keto acid dehydrogenase complex subunit E3, ...
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Disease relevance of Dld


High impact information on Dld


Biological context of Dld

  • The Dld gene is contained within an approximately 21-kb region and consists of 14 exons ranging in size from 69 to 521 nucleotides [4].
  • The Dld gene has been localized to the proximal region of chromosome 12, approximately 21 cM from the centromere [4].
  • To identify further the cis elements involved in transcription of the Dld gene (-82 bp to +41 bp), a series of mutations were introduced into this region and evaluated for functional effects using transient transfection and electrophoretic mobility shift assays [5].
  • Roles of an Ets motif and a novel CACGAC direct repeat in transcription of the murine dihydrolipoamide dehydrogenase (Dld) gene [5].

Anatomical context of Dld


Associations of Dld with chemical compounds


Analytical, diagnostic and therapeutic context of Dld

  • Northern blot analysis shows that the Dld mRNA in various tissues is approximately 2.4 kb in size [4].


  1. Antiangiogenic potency of various chemotherapeutic drugs for metronomic chemotherapy. Drevs, J., Fakler, J., Eisele, S., Medinger, M., Bing, G., Esser, N., Marmé, D., Unger, C. Anticancer Res. (2004) [Pubmed]
  2. Hepatic portal infiltrates in mice immunized with syngeneic lymphoid cells: connotations for models of autoimmune liver disease. Karanikas, V., MacKay, I.R., Rowley, M.J., Veitch, B., Loveland, B.E. J. Gastroenterol. Hepatol. (1995) [Pubmed]
  3. Novelty of the pyruvate metabolic enzyme dihydrolipoamide dehydrogenase in spermatozoa: correlation of its localization, tyrosine phosphorylation, and activity during sperm capacitation. Mitra, K., Rangaraj, N., Shivaji, S. J. Biol. Chem. (2005) [Pubmed]
  4. Characterization of the mouse dihydrolipoamide dehydrogenase (Dld) gene: genomic structure, promoter sequence, and chromosomal localization. Johnson, M., Yang, H.S., Johanning, G.L., Patel, M.S. Genomics (1997) [Pubmed]
  5. Roles of an Ets motif and a novel CACGAC direct repeat in transcription of the murine dihydrolipoamide dehydrogenase (Dld) gene. Yang, H.S., Johnson, M., Patel, M.S. Biochem. J. (1999) [Pubmed]
  6. Induction of dihydrolipoamide dehydrogenase in 3T3-L1 cells during differentiation. Carothers, D.J., Pons, G., Patel, M.S. Biochem. J. (1988) [Pubmed]
  7. Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species. Starkov, A.A., Fiskum, G., Chinopoulos, C., Lorenzo, B.J., Browne, S.E., Patel, M.S., Beal, M.F. J. Neurosci. (2004) [Pubmed]
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