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Gene Review

CD109  -  CD109 molecule

Homo sapiens

Synonyms: 150 kDa TGF-beta-1-binding protein, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7, CD109 antigen, CPAMD7, DKFZp762L1111, ...
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Disease relevance of CD109

  • Thus, these results suggested that CD109 might be a useful molecular target for the development of new therapeutics for malignant tumors, such as squamous cell carcinoma [1].
  • When CD109 expression was examined in 33 cases of human lung cell carcinomas by quantitative RT-PCR, a significant high expression of CD109 was detected in about half of squamous cell carcinomas examined, but not in adenocarcinoma, large-cell carcinoma and small-cell carcinoma [1].
  • BACKGROUND: Alloantibodies against the human platelet (PLT) alloantigen (HPA)-15 system residing on CD109 can cause fetal and neonatal alloimmune thrombocytopenia (FNAIT), posttransfusion purpura, and PLT transfusion refractoriness [2].
  • Based on a phylogenic analysis of human CD109 with other human homologs as well as orthologs from other mammalian species, C. elegans (ZK337.1) and E. coli homologs, we propose CD109 represents a novel and independent branch of the alpha2-macroglobulin/complement gene family (AMCOM) and may be its oldest member [3].

High impact information on CD109


Biological context of CD109


Anatomical context of CD109

  • Northern blot analysis showed a high level of expression of the CD109 gene only in the testis in normal human and mouse tissues [1].
  • We cloned full-length CD109 cDNA from the mammalian U373 cell line by RT-PCR and performed analysis of its corresponding genomic sequence [3].
  • RESULTS: Expression of lymphocyte activation markers CD25, CDw108, and CD109 was equivalent when PBMCs incubated with group A and O RBCs were compared [7].
  • The specificity of MoAb W7C5 was further confirmed by the selective recognition of CHO cells transfected with human CD109 cDNA [8].
  • Antibody W7C5 defines a CD109 epitope expressed on CD34+ and CD34- hematopoietic and mesenchymal stem cell subsets [8].

Associations of CD109 with chemical compounds

  • CD109 also shares motifs with certain other AMCOM members including: (1) a thioester 'GCGEQ" motif, (2) a furin site of four positively charged amino acids, and (3) a double tyrosine near the C-terminus [3].

Other interactions of CD109

  • In addition, the predicted chemical reactivity of the activated CD109 thioester is complement-like rather than resembling that of alpha 2M proteins [4].
  • Identification of CD109 as part of the TGF-beta receptor system in human keratinocytes [9].

Analytical, diagnostic and therapeutic context of CD109

  • Sequence analysis revealed that CD109 contains specific motifs in its N-terminus, that are highly conserved in all AMCOM members [3].
  • Based on the selection of PLTs expressing high amounts of CD109 on the surface (mean fluorescence intensity ratio 4-5 on expression peak on Days 2-4 after apheresis) antibody screening by the MAIPA assay was performed [2].
  • Here, we show that CD109 expression was reduced upon platelet storage in saline or by cryopreservation, but was stable when stored as whole blood or therapeutic platelet concentrate [10].


  1. Expression of CD109 in human cancer. Hashimoto, M., Ichihara, M., Watanabe, T., Kawai, K., Koshikawa, K., Yuasa, N., Takahashi, T., Yatabe, Y., Murakumo, Y., Zhang, J.M., Nimura, Y., Takahashi, M. Oncogene (2004) [Pubmed]
  2. Relevance of the HPA-15 (Gov) polymorphism on CD109 in alloimmune thrombocytopenic syndromes. Ertel, K., Al-Tawil, M., Santoso, S., Kroll, H. Transfusion (2005) [Pubmed]
  3. CD109 represents a novel branch of the alpha2-macroglobulin/complement gene family. Solomon, K.R., Sharma, P., Chan, M., Morrison, P.T., Finberg, R.W. Gene (2004) [Pubmed]
  4. Cell surface antigen CD109 is a novel member of the alpha(2) macroglobulin/C3, C4, C5 family of thioester-containing proteins. Lin, M., Sutherland, D.R., Horsfall, W., Totty, N., Yeo, E., Nayar, R., Wu, X.F., Schuh, A.C. Blood (2002) [Pubmed]
  5. Gene frequencies of the HPA-15 (Gov) platelet alloantigen system in Brazilians. Cardone, J.D., Chiba, A.K., Boturão-Neto, E., Vieira-Filho, J.P., Bordin, J.O. Transfusion medicine (Oxford, England) (2004) [Pubmed]
  6. CD109 expression in squamous cell carcinoma of the uterine cervix. Zhang, J.M., Hashimoto, M., Kawai, K., Murakumo, Y., Sato, T., Ichihara, M., Nakamura, S., Takahashi, M. Pathol. Int. (2005) [Pubmed]
  7. Leukocyte phenotypic changes in an in vitro model of ABO hemolytic transfusion reaction. Udani, M., Rao, N., Telen, M.J. Transfusion (1997) [Pubmed]
  8. Antibody W7C5 defines a CD109 epitope expressed on CD34+ and CD34- hematopoietic and mesenchymal stem cell subsets. Giesert, C., Marxer, A., Sutherland, D.R., Schuh, A.C., Kanz, L., Buhring, H.J. Ann. N. Y. Acad. Sci. (2003) [Pubmed]
  9. Identification of CD109 as part of the TGF-beta receptor system in human keratinocytes. Finnson, K.W., Tam, B.Y., Liu, K., Marcoux, A., Lepage, P., Roy, S., Bizet, A.A., Philip, A. FASEB J. (2006) [Pubmed]
  10. Detection of Gov system antibodies by MAIPA reveals an immunogenicity similar to the HPA-5 alloantigens. Berry, J.E., Murphy, C.M., Smith, G.A., Ranasinghe, E., Finberg, R., Walton, J., Brown, J., Navarrete, C., Metcalfe, P., Ouwehand, W.H. Br. J. Haematol. (2000) [Pubmed]
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