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Gene Review

Aldoc  -  aldolase C, fructose-bisphosphate

Mus musculus

Synonyms: AI847350, AU040929, Aldo3, Aldolase 3, Aldolase C, ...
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Disease relevance of Aldoc

  • Aldolase C mRNA expression is developmentally regulated in the fetal lung, rapidly downregulated in the newborn lung at birth, and inducible in the adult lung when exposed to hypoxia [1].
  • In the posterior lobe vermis these blebs are seen in both transverse and sagittal sections, are symmetrical about the midline, reproducible between neighboring sections and between individuals, and bear a constant relationship to the Purkinje cell bands as revealed by zebrin II immunocytochemistry [2].

High impact information on Aldoc


Biological context of Aldoc


Anatomical context of Aldoc


Associations of Aldoc with chemical compounds

  • Nine monoclonal mouse anti-human aldolase C antibodies, mAbs A4, A8, B4, B7, B8, C1, D9, E10, and H1, were isolated and characterized [9].
  • This level is greatly increased when the transgene consists of a chloramphenicol acetyltransferase hybrid gene directed by 5.5 kilobases of aldolase C 5'-flanking sequences [10].

Regulatory relationships of Aldoc

  • At this stage of development, the borders of the OL-protocadherin-positive Purkinje cell segments coincide with the borders of Purkinje cell segments that express zebrin II, a marker for the "late-onset" parasagittal banding pattern which persists in the adult cerebellum [14].

Other interactions of Aldoc

  • The hgn locus was linked to Aldoc (aldolase c) and whn (winged helix of nude), and located in a 0.34-cM region between D10Rat30 and D10Rat68 [15].
  • The Purkinje cells, identified by anti-zebrin II in the adult or anti-calbindin in the new born mdab1-1 mutant cerebellum, form a parasagittal banding pattern, similar to but distorted compared with the wild-type design [16].
  • In the adult weaver (wv/wv) mouse, the zebrin II expression pattern in the cerebellar vermis is abnormal, consistent with the absence of a central zone (approximately lobules VI/VII) [17].
  • Interestingly, the parasagittal expression pattern of HNK-1 is different from those reported with several other markers such as zebrin II/aldolase C and the small heat shock protein HSP25 [18].
  • The zinc finger transcription factor zif268/egr-1, also known to recognize a (G+C)-rich consensus site, did not, however, bind to the (G+C)-rich motif of the aldolase C promoter, nor could it stimulate transcription in transactivation assays from this control region [19].

Analytical, diagnostic and therapeutic context of Aldoc


  1. Hypoxia results in an HIF-1-dependent induction of brain-specific aldolase C in lung epithelial cells. Jean, J.C., Rich, C.B., Joyce-Brady, M. Am. J. Physiol. Lung Cell Mol. Physiol. (2006) [Pubmed]
  2. Blebs in the mouse cerebellar granular layer as a sign of structural inhomogeneity. 2. Posterior lobe vermis. Hawkes, R., Gallagher, E., Ozol, K. Acta anatomica. (1998) [Pubmed]
  3. Genomic sequences of aldolase C (Zebrin II) direct lacZ expression exclusively in non-neuronal cells of transgenic mice. Walther, E.U., Dichgans, M., Maricich, S.M., Romito, R.R., Yang, F., Dziennis, S., Zackson, S., Hawkes, R., Herrup, K. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  4. A key role for the HLH transcription factor EBF2COE2,O/E-3 in Purkinje neuron migration and cerebellar cortical topography. Croci, L., Chung, S.H., Masserdotti, G., Gianola, S., Bizzoca, A., Gennarini, G., Corradi, A., Rossi, F., Hawkes, R., Consalez, G.G. Development (2006) [Pubmed]
  5. Pattern deformities and cell loss in Engrailed-2 mutant mice suggest two separate patterning events during cerebellar development. Kuemerle, B., Zanjani, H., Joyner, A., Herrup, K. J. Neurosci. (1997) [Pubmed]
  6. The cloning of zebrin II reveals its identity with aldolase C. Ahn, A.H., Dziennis, S., Hawkes, R., Herrup, K. Development (1994) [Pubmed]
  7. Aldolase C/zebrin gene regulation by prolactin during pregnancy and lactation. Matsuda, M., Lockefeer, J.A., Horseman, N.D. Endocrine (2003) [Pubmed]
  8. Purkinje cell expression of the mouse aldolase C gene in transgenic mice is directed by an upstream regulatory element. Romito-Digiacomo, R.R., Walther, E.U., Williams, E.A., Herrup, K. Brain Res. Mol. Brain Res. (2005) [Pubmed]
  9. Monoclonal anti-human aldolase C antibodies that react to the isozyme group-specific sequences and generally conserved sequences of human aldolase C1. Kaihara, R., Matsuhashi, S., Kusakabe, T., Kondo, T., Iwanaga, A., Hori, K. J. Biochem. (1996) [Pubmed]
  10. Analysis of a brain-specific isozyme. Expression and chromatin structure of the rat aldolase C gene and transgenes. Makeh, I., Thomas, M., Hardelin, J.P., Briand, P., Kahn, A., Skala, H. J. Biol. Chem. (1994) [Pubmed]
  11. Identification of aldolase C compartments in the mouse cerebellar cortex by olivocerebellar labeling. Sugihara, I., Quy, P.N. J. Comp. Neurol. (2007) [Pubmed]
  12. Diverse human aldolase C gene promoter regions are required to direct specific LacZ expression in the hippocampus and Purkinje cells of transgenic mice. Buono, P., Barbieri, O., Alfieri, A., Rosica, A., Astigiano, S., Cantatore, D., Mancini, A., Fattoruso, O., Salvatore, F. FEBS Lett. (2004) [Pubmed]
  13. Differential distribution of MAP1a and aldolase c in adult mouse cerebellum. Touri, F., Hawkes, R., Riederer, B.M. Eur. J. Neurosci. (1996) [Pubmed]
  14. Granule cell raphes in the developing mouse cerebellum. Luckner, R., Obst-Pernberg, K., Hirano, S., Suzuki, S.T., Redies, C. Cell Tissue Res. (2001) [Pubmed]
  15. Fine mapping of the region including hypogonadism (hgn) locus on rat chromosome 10. Suzuki, H., Nakamiya, E., Daigo, K., Saito, K., Suzuki, K. J. Vet. Med. Sci. (2004) [Pubmed]
  16. Cerebellar abnormalities in the disabled (mdab1-1) mouse. Gallagher, E., Howell, B.W., Soriano, P., Cooper, J.A., Hawkes, R. J. Comp. Neurol. (1998) [Pubmed]
  17. Selective Purkinje cell ectopia in the cerebellum of the weaver mouse. Armstrong, C., Hawkes, R. J. Comp. Neurol. (2001) [Pubmed]
  18. Abnormal HNK-1 expression in the cerebellum of an N-CAM null mouse. Marzban, H., Sillitoe, R.V., Hoy, M., Chung, S.H., Rafuse, V.F., Hawkes, R. J. Neurocytol. (2004) [Pubmed]
  19. A (G+C)-rich motif in the aldolase C promoter functions as a constitutive transcriptional enhancer element. Cibelli, G., Schoch, S., Pajunk, H., Brand, I.A., Thiel, G. Eur. J. Biochem. (1996) [Pubmed]
  20. Patterned Purkinje cell degeneration in mouse models of Niemann-Pick type C disease. Sarna, J.R., Larouche, M., Marzban, H., Sillitoe, R.V., Rancourt, D.E., Hawkes, R. J. Comp. Neurol. (2003) [Pubmed]
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