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Gene Review

Igsf8  -  immunoglobulin superfamily, member 8

Mus musculus

Synonyms: AA033172, AU041109, CD81 partner 3, ESTM34, EWI-2, ...
 
 
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Disease relevance of Igsf8

 

High impact information on Igsf8

  • Functionally, silencing of endogenous EWI-2 expression by short interfering RNA in lymphoid CEM cells augmented cell migration, cellular polarity, and increased phosphorylation of ERMs [2].
  • Confocal microscopy analysis revealed that EWI-2 and EWI-F colocalized with ERM proteins at microspikes and microvilli of adherent cells and at the cellular uropod in polarized migrating leukocytes [2].
  • EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins [2].
  • PGRL is a major CD81-associated protein on lymphocytes and distinguishes a new family of cell surface proteins [3].
  • Although it remains to be determined whether PGRL possesses PG regulatory functions, transwell chamber experiments show that PGs and CD81 coordinately regulate T cell motility [3].
 

Biological context of Igsf8

 

Anatomical context of Igsf8

 

Associations of Igsf8 with chemical compounds

  • A novel Ig superfamily protein, EWI-2, was co-purified with tetraspanin protein CD81 under relatively stringent Brij 96 detergent conditions and identified by mass spectrometric protein sequencing [6].
 

Analytical, diagnostic and therapeutic context of Igsf8

References

  1. Neuronal expression of keratinocyte-associated transmembrane protein-4, KCT-4, in mouse brain and its up-regulation by neurite outgrowth of Neuro-2a cells. Yamada, O., Tamura, K., Yagihara, H., Isotani, M., Washizu, T., Bonkobara, M. Neurosci. Lett. (2006) [Pubmed]
  2. EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins. Sala-Valdés, M., Ursa, A., Charrin, S., Rubinstein, E., Hemler, M.E., Sánchez-Madrid, F., Yáñez-Mó, M. J. Biol. Chem. (2006) [Pubmed]
  3. PGRL is a major CD81-associated protein on lymphocytes and distinguishes a new family of cell surface proteins. Clark, K.L., Zeng, Z., Langford, A.L., Bowen, S.M., Todd, S.C. J. Immunol. (2001) [Pubmed]
  4. Genomic organization and embryonic expression of Igsf8, an immunoglobulin superfamily member implicated in development of the nervous system and organ epithelia. Murdoch, J.N., Doudney, K., Gerrelli, D., Wortham, N., Paternotte, C., Stanier, P., Copp, A.J. Mol. Cell. Neurosci. (2003) [Pubmed]
  5. EWI-2 is a new component of the tetraspanin web in hepatocytes and lymphoid cells. Charrin, S., Le Naour, F., Labas, V., Billard, M., Le Caer, J.P., Emile, J.F., Petit, M.A., Boucheix, C., Rubinstein, E. Biochem. J. (2003) [Pubmed]
  6. EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily. Stipp, C.S., Kolesnikova, T.V., Hemler, M.E. J. Biol. Chem. (2001) [Pubmed]
 
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