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Gene Review

PTGFRN  -  prostaglandin F2 receptor inhibitor

Homo sapiens

Synonyms: CD315, CD9 partner 1, CD9P-1, CD9P1, EWI-F, ...
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Disease relevance of PTGFRN

  • This idea was tested through attempts to construct viruses encoding the immunoglobulin loop 6 and transmembrane regions of the prostaglandin F2alpha receptor regulatory protein (FPRP), a product that inhibits adenovirus vector construction for reasons that are not clear [1].

High impact information on PTGFRN

  • Confocal microscopy analysis revealed that EWI-2 and EWI-F colocalized with ERM proteins at microspikes and microvilli of adherent cells and at the cellular uropod in polarized migrating leukocytes [2].
  • EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins [2].
  • CD9P-1 was also shown to form separate complexes with CD81 and with an unidentified 175-kDa molecule [3].
  • Cross-linking experiments detected a complex of the size of CD9 plus CD9P-1, showing that these glycoproteins directly associate with each other, probably in the absence of any other molecule [3].
  • Although CD81 associated with both alpha(3) integrin and FPRP in 293 cells, the alpha(3)beta(1).CD81 and CD81.CD9.FPRP complexes were distinct, as determined by immunoprecipitation and immunodepletion experiments [4].

Biological context of PTGFRN


Anatomical context of PTGFRN


Associations of PTGFRN with chemical compounds

  • Histologically, this protein (FP regulatory protein or FPRP) shows a distribution coinciding well with those cells and tissues that respond to PGF2alpha [5].
  • One of the most prominent proteins within CD81 and CD9 complexes is identified here as FPRP, the 133-kDa prostaglandin F(2alpha) receptor regulatory protein [4].
  • FPRP, a transmembrane glycoprotein, has been shown to regulate the binding of ligand to certain seven-transmembrane receptors [8].
  • Differentiation induction with either dexamethasone/insulin/isobutylmethylxanthine or the thiazolidinedione derivative ADD 4743 were both effective at inducing FPRP accumulation and accumulation of lipid droplets [8].
  • Treatment of 3T3-L1 cells with an FPRP anti-sense oligonucleotide during differentiation decreased FPRP accumulation and resulted in a decrease in lipid droplets without altering the level of induction of a late marker of adipocyte differentiation, glycerol-3-phosphate dehydrogenase activity [8].

Analytical, diagnostic and therapeutic context of PTGFRN


  1. Promoter strength in adenovirus transducing vectors: down-regulation of the adenovirus E1A promoter in 293 cells facilitates vector construction. Schaack, J., Allen, B., Orlicky, D.J., Bennett, M.L., Maxwell, I.H., Smith, R.L. Virology (2001) [Pubmed]
  2. EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins. Sala-Valdés, M., Ursa, A., Charrin, S., Rubinstein, E., Hemler, M.E., Sánchez-Madrid, F., Yáñez-Mó, M. J. Biol. Chem. (2006) [Pubmed]
  3. The major CD9 and CD81 molecular partner. Identification and characterization of the complexes. Charrin, S., Le Naour, F., Oualid, M., Billard, M., Faure, G., Hanash, S.M., Boucheix, C., Rubinstein, E. J. Biol. Chem. (2001) [Pubmed]
  4. FPRP, a major, highly stoichiometric, highly specific CD81- and CD9-associated protein. Stipp, C.S., Orlicky, D., Hemler, M.E. J. Biol. Chem. (2001) [Pubmed]
  5. Human chromosome 1 localization of the gene for a prostaglandin F2alpha receptor negative regulatory protein. Orlicky, D.J., Berry, R., Sikela, J.M. Hum. Genet. (1996) [Pubmed]
  6. Negative regulatory activity of a prostaglandin F2 alpha receptor associated protein (FPRP). Orlicky, D.J. Prostaglandins Leukot. Essent. Fatty Acids (1996) [Pubmed]
  7. EWI-2 is a new component of the tetraspanin web in hepatocytes and lymphoid cells. Charrin, S., Le Naour, F., Labas, V., Billard, M., Le Caer, J.P., Emile, J.F., Petit, M.A., Boucheix, C., Rubinstein, E. Biochem. J. (2003) [Pubmed]
  8. Synthesis and accumulation of a receptor regulatory protein associated with lipid droplet accumulation in 3T3-L1 cells. Orlicky, D.J., Lieber, J.G., Morin, C.L., Evans, R.M. J. Lipid Res. (1998) [Pubmed]
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