Disease relevance of ITLN2

• The specific lead positions HL1 and HL2 were chosen to detect anterior and postero-inferior myocardial ischemia, respectively, without interfering with the surgical field in the hypothetical situation of open-heart surgery [1].

High impact information on ITLN2

• HDM2-HL2 was able to inhibit transactivation of a p53-inducible reporter construct and induced a partial relocalization of p53 to the cytoplasm [2].
• The proligand HL2 (N-(2'-hydroxybenzyl)-2-amino-2-deoxy-D-glucose) was produced by hydrogenation of the corresponding Schiff base and reacted with [NEt4]2[Re(CO)3Br3] to form the neutral complex [(L2)Re(CO)3] in 40% yield [3].
• The cDNAs encoding two human homologs of the XENOPUS: oocyte lectin, XL35, were isolated from a small intestine cDNA library and termed HL-1 and HL-2 [4].
• HL-2 transcripts, by contrast, are expressed only in small intestine [4].
• Compared to infection of HeLa cells, lacZ expression from vd120/LTR beta-infected HL2/3 and HLtat cells increased from 4- to 24-fold, depending on the multiplicity of vector infection [5].

Biological context of ITLN2

• Upon cocultivation of HL2/3 and HLCD4-CAT cells, efficient cell fusion is observed within 8 h [6].
• There was only limited correlation between flagellar RFLP and the Lior serogroup, and the variability of patterns in serogroups HL2 and HL4 were as marked as the variability between serogroups [7].

Anatomical context of ITLN2

• The predicted protein has 62-70% amino acid identity with the Xenopus oocyte cortical granule lectin (XCGL), the mouse intelectin, the human HL-1/intelectin and HL-2 [8].
• However, ligands HL2 and HL3 and their corresponding copper complexes demonstrated very weak in vitro activities towards the cell lines examined [9].
• There were some foam cells and depositions of lipochondria in aortic tunica intima in HC and HL1 rats, which were not found in HL2 and HL3 rats [10].
• The analysis by circular dichroism (CD) spectroscopy of the interaction of the Zn/HL2 compound with calf thymus DNA (CT DNA) indicates that it produces stronger alterations on the double helix conformation than cis-DDP [11].
• Antiproliferative activities of ([CuCl2(L1)2]) and [CuCl2(H2L2)]Cl, where HL2 is the 5-thioxo analog of L1, against human tumor cell lines HT1080 and HT29 as well as normal human fibroblasts (HF) are presented along with the antiproliferative activities of L1, CuCl2, and cisplatin [12].

Associations of ITLN2 with chemical compounds

• Three new ligands, N-(8-quinolyl)pyridine-2-carboxamide (HL1), N-(8-quinolyl)glycine-N'-Boc-carboxamide (HL2), N-(8-quinolyl)-L-alanine-N'-Boc-carboxamide (HL3), and their Cu(II) complexes have been synthesized [9].
• The reactions of 2-(arylazo) anilines, HL (1) [where HL is 2-(ArN=N)C6H4NH2; Ar is C6H5 (for HL1, 1a) and p-MeC6H4 (for HL2, 1b); H of HL represents the proton of Ar which gets dissociated upon orthometalation] with RhCl3 in methanol afforded new orthometalated complexes of composition (L)(HL)Rh(III)Cl2 (2) and (L)(ArNH2)Rh(III)Cl2 (3) [13].
• We have prepared complexes of HL1 and HL2 with Zn(II) and Cd(II) [11].
• Reaction with the form HL-2 (only the amino nitrogen protonated), the dominant form of this species, proceeds by the expected rat limiting water loss (dissociative or Eigen) mechanism with rate constants of 9.3 X 10(7) M-1 sec-1 (+/- 24%) for mono and 5.1 X 10(7) M-1 sec-1 (+/- 25%) for bis complex formation [14].
• It is known that metallic complexes of methyl 2-pyridyl ketone thiosemicarbazone (HL1) and p-isopropyl benzaldehyde thiosemicarbazone (HL2) may have potential antitumor activity [11].

References