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Gene Review

ITLN1  -  intelectin 1 (galactofuranose binding)

Homo sapiens

Synonyms: Endothelial lectin HL-1, FLJ20022, Galactofuranose-binding lectin, HL-1, HL1, ...
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Disease relevance of ITLN1

  • Recombinant hIntL revealed affinities to d-pentoses and a d-galactofuranosyl residue in the presence of Ca(2+), and recognized the bacterial arabinogalactan of Nocardia containing d-galactofuranosyl residues [1].
  • Since lactoferrin has been found in significant amounts in human stomach resection specimens from patients with superficial or atrophic gastritis, the iron uptake of H. pylori via a specific HLf receptor may play a major role in the virulence of H. pylori infection [2].
  • An increase in the concentration of FeCl3 or the Fe3+-saturation of bovine LFR, however, slightly reduced its inhibition of the hemolysis [3].
  • Previously, we found polymorphonuclear neutrophils (PMNs) increased melanoma cell extravasation under flow conditions (Intl J Cancer 106: 713-722, 2003) [4].
  • The prominence of the alpha-subclass of Proteobacteria in the marine bacterioplankton community and their role in dimethylsulfide (DMS) production has prompted a detailed examination of dimethylsulfoniopropionate (DMSP) metabolism in a representative isolate of this phylotype, strain LFR [5].

Psychiatry related information on ITLN1

  • The esthetic significance of variations in the AP position of the mandible was investigated by using 3 methods: a traditional semantic differential scale, the Perceptometrics method (Health Programs Intl, Wellesley, Mass), and the implicit association test (IAT) [6].

High impact information on ITLN1


Biological context of ITLN1


Anatomical context of ITLN1


Associations of ITLN1 with chemical compounds

  • Characterization of Lf receptors was performed by flow cytofluorimetry using either Lf labelled on its glycan moiety with fluorescein or purified anti-lymphocyte Lf receptor antibodies [16].
  • Lactoferrin (LFR) plays an important role in the anti-microbial defense through iron binding, lipopolysaccharide binding and immunomodulation [3].
  • A putative model is presented that best fits the experimental data regarding the pathway of DMSP and acrylate metabolism in the alpha-proteobacterium, strain LFR [5].
  • All methods are referenced to the same standard (WHO 1st Intl. Std. for AFP 72/225) [17].
  • The reaction of IrCl3.3H2O with 2-(arylazo)pyridine (HL1) in boiling methanol has afforded [Ir(III)Cl2(L1)(HL1)](1) and [Ir(V)Cl4(HL1)]Cl (2) [18].

Other interactions of ITLN1

  • Acute- and convalescent-phase antisera from a series of patients with M. catarrhalis pulmonary infections were tested against Tf and Lf receptor proteins purified from the corresponding isolates [19].
  • The polyester rods demonstrated a trend toward enhanced recovery, but this difference was not statistically significant (p = 0.12, LFR; p = 0.055, EGF) [20].

Analytical, diagnostic and therapeutic context of ITLN1


  1. Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall. Tsuji, S., Uehori, J., Matsumoto, M., Suzuki, Y., Matsuhisa, A., Toyoshima, K., Seya, T. J. Biol. Chem. (2001) [Pubmed]
  2. Identification, characterization, and immunogenicity of the lactoferrin-binding protein from Helicobacter pylori. Dhaenens, L., Szczebara, F., Husson, M.O. Infect. Immun. (1997) [Pubmed]
  3. Inhibition of listeriolysin O-induced hemolysis by bovine lactoferrin. Moriishi, K., Inoue, S., Koura, M., Amano, F. Biol. Pharm. Bull. (1999) [Pubmed]
  4. Distinct role of hydrodynamic shear in leukocyte-facilitated tumor cell extravasation. Slattery, M.J., Liang, S., Dong, C. Am. J. Physiol., Cell Physiol. (2005) [Pubmed]
  5. Nuclear magnetic resonance analysis of [1-13C]dimethylsulfoniopropionate (DMSP) and [1-13C]acrylate metabolism by a DMSP lyase-producing marine isolate of the alpha-subclass of Proteobacteria. Ansede, J.H., Pellechia, P.J., Yoch, D.C. Appl. Environ. Microbiol. (2001) [Pubmed]
  6. Methods to evaluate profile preferences for the anteroposterior position of the mandible. Orsini, M.G., Huang, G.J., Kiyak, H.A., Ramsay, D.S., Bollen, A.M., Anderson, N.K., Giddon, D.B. American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics. (2006) [Pubmed]
  7. The binding of human lactoferrin to mouse peritoneal cells. Van Snick, J.L., Masson, P.L. J. Exp. Med. (1976) [Pubmed]
  8. Opposing selective forces for expression of the gonococcal lactoferrin receptor. Anderson, J.E., Hobbs, M.M., Biswas, G.D., Sparling, P.F. Mol. Microbiol. (2003) [Pubmed]
  9. Intelectin: a novel lipid raft-associated protein in the enterocyte brush border. Wrackmeyer, U., Hansen, G.H., Seya, T., Danielsen, E.M. Biochemistry (2006) [Pubmed]
  10. The N-terminal Arg2, Arg3 and Arg4 of human lactoferrin interact with sulphated molecules but not with the receptor present on Jurkat human lymphoblastic T-cells. Legrand, D., van Berkel, P.H., Salmon, V., van Veen, H.A., Slomianny, M.C., Nuijens, J.H., Spik, G. Biochem. J. (1997) [Pubmed]
  11. Human homologs of the Xenopus oocyte cortical granule lectin XL35. Lee, J.K., Schnee, J., Pang, M., Wolfert, M., Baum, L.G., Moremen, K.W., Pierce, M. Glycobiology (2001) [Pubmed]
  12. Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action. Yang, R.Z., Lee, M.J., Hu, H., Pray, J., Wu, H.B., Hansen, B.C., Shuldiner, A.R., Fried, S.K., McLenithan, J.C., Gong, D.W. Am. J. Physiol. Endocrinol. Metab. (2006) [Pubmed]
  13. Baculovirus expression of mouse lactoferrin receptor and tissue distribution in the mouse. Suzuki, Y.A., Lönnerdal, B. Biometals (2004) [Pubmed]
  14. Novel function of bovine milk-derived lactoferrin on antinociception mediated by mu-opioid receptor in the rat spinal cord. Hayashida, K., Takeuchi, T., Shimizu, H., Ando, K., Harada, E. Brain Res. (2003) [Pubmed]
  15. Identification and isolation of a 45-kDa calcium-dependent lactoferrin receptor from rat hepatocytes. Bennatt, D.J., McAbee, D.D. Biochemistry (1997) [Pubmed]
  16. Characterization of two kinds of lactotransferrin (lactoferrin) receptors on different target cells. Spik, G., Legrand, D., Leveugle, B., Mazurier, J., Mikogami, T., Montreuil, J., Pierce, A., Rochard, E. Adv. Exp. Med. Biol. (1994) [Pubmed]
  17. Serum alpha-fetoprotein: I. Evaluation of quantitative assays adapted to automated immunoassay systems. Gadsden, R.H., Cate, J.C. Ann. Clin. Lab. Sci. (1991) [Pubmed]
  18. Isolation and characterization of iridium(III) and iridium(V) complexes of 2-(arylazo)pyridine and studies of amine fusion reactions at the coordinated diazo-ligand. Panda, M., Das, C., Lee, G.H., Peng, S.M., Goswami, S. Dalton transactions (Cambridge, England : 2003) (2004) [Pubmed]
  19. Analysis of the immunological responses to transferrin and lactoferrin receptor proteins from Moraxella catarrhalis. Yu, R.H., Bonnah, R.A., Ainsworth, S., Schryvers, A.B. Infect. Immun. (1999) [Pubmed]
  20. A novel method of tear collection: comparison of glass capillary micropipettes with porous polyester rods. Jones, D.T., Monroy, D., Pflugfelder, S.C. Cornea (1997) [Pubmed]
  21. Molecular cloning and functional expression of a human intestinal lactoferrin receptor. Suzuki, Y.A., Shin, K., Lönnerdal, B. Biochemistry (2001) [Pubmed]
  22. Isolation and function of a receptor for human lactoferrin in human fetal intestinal brush-border membranes. Kawakami, H., Lönnerdal, B. Am. J. Physiol. (1991) [Pubmed]
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