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OR2AG1  -  olfactory receptor, family 2, subfamily AG...

Homo sapiens

Synonyms: HT3, OR11-79, OR2AG3, Olfactory receptor 2AG1, Olfactory receptor 2AG3, ...
 
 
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Disease relevance of OR2AG1

  • To determine whether q13 rearrangement is a nonrandom event in cervical carcinomas, six different human papilloma virus (HPV)-positive (HeLa, SiHa, Caski, C4-I, Me180, and Ms751) and two different HPV-negative (C33A and HT3) cell lines were studied [1].
  • The number of carriers of HT3 and HT5 was too low to make an accurate estimate of the risk of venous thrombosis [2].
  • Treatment with 10 nM 17beta-estradiol blocked apoptosis induced by the P2X7-receptor ligands ATP and 2',3'-0-(4-benzoylbenzoyl)-ATP in normal human cervical epithelial cells (hECEs) and attenuated the effect in hECEs immortalized with human papillomavirus-16 (ECE16-1) and the cancer cervical cells HT3 and CaSki [3].
  • We analyzed the association of three FVIII gene haplotypes encoding 1241E (further denoted as HT1, HT3, and HT5) with FVIII levels and thrombosis risk [2].
  • We found that patients with plaque psoriasis had a higher frequency of the HT3 GAA haplotype (P<0.01, OR 2.341, 95% CI: 1.346-4.074) compared to the control group [4].
 

High impact information on OR2AG1

  • Long-range restriction mapping using a number of q13-specific probes showed molecular rearrangements within 75 kb of INT2 probe in three HPV-positive cell lines (HeLa, SiHa, and Caski) and in an HPV-negative cell line (HT3) [1].
  • Likewise, the HT3 GAA haplotype was associated with an increased risk of early-onset psoriasis (P<0.01, OR 2.305, 95% CI: 1.285-4.132), late onset of disease (P<0.01, OR 2.542, 95% CI: 1.266-5.102), familial psoriasis (P<0.02, OR 2.220, 95% CI: 1.249-3.945), and sporadic disease (P<0.01, OR 2.523, 95% CI: 1.390-4.580) [4].
  • RESULTS: For each cervical cancer cell, IC50 was as follows; CaSki (68.5 multiplicity of infection, or MOI), SiHa (43.5 MOI), HeLa (31 MOI), HeLaS3 (42 MOI), C33A (21 MOI), and HT3 (62 MOI) [5].
  • METHODS: Cervical cells (ECE16-1, Caski, and HT3) were grown on filters, and transepithelial electrical conductance (GT) and the permeability to pyranine (PPyr) were determined [6].
  • One large randomised trial demonstrated that aprepitant substantially reduces the risk of vomiting or retching when added to a corticosteroid and a 5-hydroxytryptamine 3 (HT3) receptor antagonist [7].
 

Chemical compound and disease context of OR2AG1

 

Biological context of OR2AG1

  • The growth of CaSki cervical cancer cells was only 10-15% inhibited by Rep 78, and the other cervical cells, HeLa, HeLaS3, HT3, and QGU, were unaffected by Rep 78 transfection [10].
  • To evaluate anti-tumor effects of recombinant adenovirus p53, time-course p53, E6 expression, and cell growth inhibition were investigated in vitro and in vivo using cervical cancer cell lines such as CaSki, SiHa, HeLa, HeLaS3, C33A, and HT3 [11].
 

Analytical, diagnostic and therapeutic context of OR2AG1

  • E-cadherin expression (120 kD form on Western blotting) was seen in human cervical carcinoma cell lines (HT3, ME180, C4I, Caski) that maintained the ability to aggregate in a homotypic adhesion assay and showed a typical epithelial morphology [12].
  • The single-cell gel electrophoresis (comet) assay was used to measure radiation-produced DNA double-strand breaks (dsbs) in a series of seven cervical tumour cell lines (ME180, HT3, C33A, C41, SiHa, MS751 and CaSki) [13].
  • RT-PCR for TA and DeltaN form and three isoforms of p63 showed positive bands for both TA and DeltaN forms and for all three isoforms in cervical cancer cell lines but weak band for alpha isoform in HPV-negative HT3 SCC cell line and no band for beta isoform in HeLa adenocarcinoma cell line [14].

References

  1. Deletion and translocation of chromosome 11q13 sequences in cervical carcinoma cell lines. Jesudasan, R.A., Rahman, R.A., Chandrashekharappa, S., Evans, G.A., Srivatsan, E.S. Am. J. Hum. Genet. (1995) [Pubmed]
  2. Haplotypes encoding the factor VIII 1241 Glu variation, factor VIII levels and the risk of venous thrombosis. Nossent, A.Y., Eikenboom, J.C., Vos, H.L., Bakker, E., Tanis, B.C., Doggen, C.J., Bertina, R.M., Rosendaal, F.R. Thromb. Haemost. (2006) [Pubmed]
  3. Antiapoptotic effects of estrogen in normal and cancer human cervical epithelial cells. Wang, Q., Li, X., Wang, L., Feng, Y.H., Zeng, R., Gorodeski, G. Endocrinology (2004) [Pubmed]
  4. Polymorphisms in the interleukin-20 gene: relationships to plaque-type psoriasis. Kingo, K., Kõks, S., Nikopensius, T., Silm, H., Vasar, E. Genes Immun. (2004) [Pubmed]
  5. Recombinant adenovirus-p53 gene transfer and cell-specific growth suppression of human cervical cancer cells in vitro and in vivo. Ahn, W.S., Bae, S.M., Lee, K.H., Lee, J.M., Namkoong, S.E., Chun, H.J., Kim, C.K., Kim, Y.W. Gynecol. Oncol. (2004) [Pubmed]
  6. Characterization of paracellular permeability in cultured human cervical epithelium: regulation by extracellular adenosine triphosphate. Gorodeski, G.I., Merlin, D., De Santis, B.J., Frieden, K.A., Hopfer, U., Eckert, R.L., Utian, W.H., Romero, M.F. J. Soc. Gynecol. Investig. (1994) [Pubmed]
  7. The neurokinin1 receptor antagonist aprepitant as an antiemetic for moderately emetogenic chemotherapy. Warr, D. Expert opinion on pharmacotherapy. (2006) [Pubmed]
  8. Prophylactic administration of ondansetron in emergency intraabdominal operations. Ulusoy, H.O., Aktürk, G., Lüleci, N., Kalaç, N., Albayrak, D. Middle East journal of anesthesiology. (1997) [Pubmed]
  9. Necrosis-like death with plasma membrane damage against cervical cancer cells by photodynamic therapy. Ahn, W.S., Bae, S.M., Huh, S.W., Lee, J.M., Namkoong, S.E., Han, S.J., Kim, C.K., Kim, J.K., Kim, Y.W. Int. J. Gynecol. Cancer (2004) [Pubmed]
  10. Development of anticancer gene vaccine interact with human papillomavirus oncoprotein inhibition. Ahn, W.S., Bae, S.M., Lee, H.J., Kim, Y.W., Lee, J.M., Namkoong, S.E., Kim, C.K., Kim, Y.W., Jin, H.S. Int. J. Gynecol. Cancer (2006) [Pubmed]
  11. Anti-cancer effect of adenovirus p53 on human cervical cancer cell growth in vitro and in vivo. Ahn, W.S., Bae, S.M., Lee, J.M., Namkoong, S.E., Yoo, J.Y., Seo, Y.S., Nam, S.L., Cho, Y.L., Nam, K.H., Kim, C.K., Kim, Y.W. Int. J. Gynecol. Cancer (2004) [Pubmed]
  12. Altered expression and function of E-cadherin in cervical intraepithelial neoplasia and invasive squamous cell carcinoma. Vessey, C.J., Wilding, J., Folarin, N., Hirano, S., Takeichi, M., Soutter, P., Stamp, G.W., Pignatelli, M. J. Pathol. (1995) [Pubmed]
  13. The ratio of initial/residual DNA damage predicts intrinsic radiosensitivity in seven cervix carcinoma cell lines. Marples, B., Longhurst, D., Eastham, A.M., West, C.M. Br. J. Cancer (1998) [Pubmed]
  14. Reverse transcription-polymerase chain reaction and western blotting analysis for detection of p63 isoforms in uterine cervical cancers. Lin, Z., Nan, Y., Zhang, X., Zhao, Y., Kim, C., Kim, I. Int. J. Gynecol. Cancer (2006) [Pubmed]
 
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