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Gene Review

Nrtn  -  neurturin

Mus musculus

Synonyms: Neurturin
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Disease relevance of Nrtn


High impact information on Nrtn


Biological context of Nrtn


Anatomical context of Nrtn


Associations of Nrtn with chemical compounds

  • Our findings indicate that GDNF and neurturin promote neuronal survival by signalling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity [3].
  • Loss of nitrergic neurotransmission to mouse corpus cavernosum in the absence of neurturin is accompanied by increased response to acetylcholine [17].
  • However, we report here that GDNF and neurturin blocked the growth inhibitory and neuritogenic effects of all-trans-retinoic acid in neuroblastoma cells in vitro [18].

Physical interactions of Nrtn


Regulatory relationships of Nrtn

  • We conclude that GDNF and neurturin potently upregulate functional B1 receptor expression in small non-peptidergic nociceptive neurones [20].

Other interactions of Nrtn


Analytical, diagnostic and therapeutic context of Nrtn


  1. Glial cell line-derived neurotrophic factor family members sensitize nociceptors in vitro and produce thermal hyperalgesia in vivo. Malin, S.A., Molliver, D.C., Koerber, H.R., Cornuet, P., Frye, R., Albers, K.M., Davis, B.M. J. Neurosci. (2006) [Pubmed]
  2. Neurturin-deficient mice develop dry eye and keratoconjunctivitis sicca. Song, X.J., Li, D.Q., Farley, W., Luo, L.H., Heuckeroth, R.O., Milbrandt, J., Pflugfelder, S.C. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  3. Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase. Buj-Bello, A., Adu, J., Piñón, L.G., Horton, A., Thompson, J., Rosenthal, A., Chinchetru, M., Buchman, V.L., Davies, A.M. Nature (1997) [Pubmed]
  4. Alimentary tract innervation deficits and dysfunction in mice lacking GDNF family receptor alpha2. Rossi, J., Herzig, K.H., Võikar, V., Hiltunen, P.H., Segerstråle, M., Airaksinen, M.S. J. Clin. Invest. (2003) [Pubmed]
  5. Retarded growth and deficits in the enteric and parasympathetic nervous system in mice lacking GFR alpha2, a functional neurturin receptor. Rossi, J., Luukko, K., Poteryaev, D., Laurikainen, A., Sun, Y.F., Laakso, T., Eerikäinen, S., Tuominen, R., Lakso, M., Rauvala, H., Arumäe, U., Pasternack, M., Saarma, M., Airaksinen, M.S. Neuron (1999) [Pubmed]
  6. Gene targeting reveals a critical role for neurturin in the development and maintenance of enteric, sensory, and parasympathetic neurons. Heuckeroth, R.O., Enomoto, H., Grider, J.R., Golden, J.P., Hanke, J.A., Jackman, A., Molliver, D.C., Bardgett, M.E., Snider, W.D., Johnson, E.M., Milbrandt, J. Neuron (1999) [Pubmed]
  7. Development and persistence of kindling epilepsy are impaired in mice lacking glial cell line-derived neurotrophic factor family receptor alpha 2. Nanobashvili, A., Airaksinen, M.S., Kokaia, M., Rossi, J., Asztély, F., Olofsdotter, K., Mohapel, P., Saarma, M., Lindvall, O., Kokaia, Z. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  8. Neural cells in the esophagus respond to glial cell line-derived neurotrophic factor and neurturin, and are RET-dependent. Yan, H., Bergner, A.J., Enomoto, H., Milbrandt, J., Newgreen, D.F., Young, H.M. Dev. Biol. (2004) [Pubmed]
  9. Cloning of a novel murine isoform of the glial cell line-derived neurotrophic factor receptor. Dey, B.K., Wong, Y.W., Too, H.P. Neuroreport (1998) [Pubmed]
  10. Transient disruption of spermatogenesis by deregulated expression of neurturin in testis. Meng, X., Pata, I., Pedrono, E., Popsueva, A., de Rooij, D.G., Jänne, M., Rauvala, H., Sariola, H. Mol. Cell. Endocrinol. (2001) [Pubmed]
  11. Neurturin, a novel neurotrophic factor, is localized to mouse chromosome 17 and human chromosome 19p13.3. Heuckeroth, R.O., Kotzbauer, P., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Zimonjic, D.B., Popescu, N.C., Johnson, E.M., Milbrandt, J. Genomics (1997) [Pubmed]
  12. Neurturin and glial cell line-derived neurotrophic factor receptor-beta (GDNFR-beta), novel proteins related to GDNF and GDNFR-alpha with specific cellular patterns of expression suggesting roles in the developing and adult nervous system and in peripheral organs. Widenfalk, J., Nosrat, C., Tomac, A., Westphal, H., Hoffer, B., Olson, L. J. Neurosci. (1997) [Pubmed]
  13. Neurturin: an autocrine regulator of renal collecting duct development. Davies, J.A., Millar, C.B., Johnson, E.M., Milbrandt, J. Dev. Genet. (1999) [Pubmed]
  14. Molecular cloning and expression analysis of GFR alpha-3, a novel cDNA related to GDNFR alpha and NTNR alpha. Nomoto, S., Ito, S., Yang, L.X., Kiuchi, K. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  15. New roles for glial cell line-derived neurotrophic factor and neurturin: involvement in hair cycle control. Botchkareva, N.V., Botchkarev, V.A., Welker, P., Airaksinen, M., Roth, W., Suvanto, P., Müller-Röver, S., Hadshiew, I.M., Peters, C., Paus, R. Am. J. Pathol. (2000) [Pubmed]
  16. Expression patterns of neurturin and its receptor components in developing and degenerative mouse retina. Jomary, C., Thomas, M., Grist, J., Milbrandt, J., Neal, M.J., Jones, S.E. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
  17. Loss of nitrergic neurotransmission to mouse corpus cavernosum in the absence of neurturin is accompanied by increased response to acetylcholine. Nangle, M.R., Keast, J.R. Br. J. Pharmacol. (2006) [Pubmed]
  18. Glial cell line-derived neurotrophic factor (GDNF) family ligands reduce the sensitivity of neuroblastoma cells to pharmacologically induced cell death, growth arrest and differentiation. Hansford, L.M., Marshall, G.M. Neurosci. Lett. (2005) [Pubmed]
  19. Impaired behavioural flexibility and memory in mice lacking GDNF family receptor alpha2. Võikar, V., Rossi, J., Rauvala, H., Airaksinen, M.S. Eur. J. Neurosci. (2004) [Pubmed]
  20. Functional bradykinin B1 receptors are expressed in nociceptive neurones and are upregulated by the neurotrophin GDNF. Vellani, V., Zachrisson, O., McNaughton, P.A. J. Physiol. (Lond.) (2004) [Pubmed]
  21. GDNF availability determines enteric neuron number by controlling precursor proliferation. Gianino, S., Grider, J.R., Cresswell, J., Enomoto, H., Heuckeroth, R.O. Development (2003) [Pubmed]
  22. Distinct roles for GFRalpha1 and GFRalpha2 signalling in different cranial parasympathetic ganglia in vivo. Rossi, J., Tomac, A., Saarma, M., Airaksinen, M.S. Eur. J. Neurosci. (2000) [Pubmed]
  23. Localization of cholinergic innervation and neurturin receptors in adult mouse heart and expression of the neurturin gene. Mabe, A.M., Hoard, J.L., Duffourc, M.M., Hoover, D.B. Cell Tissue Res. (2006) [Pubmed]
  24. Glial cell line-derived neurotrophic factor and developing mammalian motoneurons: regulation of programmed cell death among motoneuron subtypes. Oppenheim, R.W., Houenou, L.J., Parsadanian, A.S., Prevette, D., Snider, W.D., Shen, L. J. Neurosci. (2000) [Pubmed]
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