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Gene Review

Gpx5  -  glutathione peroxidase 5

Mus musculus

Synonyms: AV379049, Arep, EGLP, Epididymal secretory glutathione peroxidase, Epididymis-specific glutathione peroxidase-like protein, ...
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Disease relevance of Gpx5


High impact information on Gpx5


Biological context of Gpx5

  • This report presents data that suggest that the tissue-restricted polyoma enhancer activator protein (PEA3) of the Ets oncogene family of DNA-binding proteins is a putative modulator of the epididymis-specific glutathione peroxidase 5 gene gpx5 [5].
  • The gpx5 androgen response element (ARE) is found to be consistent with the consensus palindromic steroid-receptor target sequence 5'-AGWACWnnnTGTYCT-3' but exhibits a quite weak conservation in the left half site [6].
  • We report here, using run-on assays, transient expression experiments as well as gel-shift and footprinting analyses on the findings that at least part of the androgenic control of the GPX5 expression is exerted at the transcriptional level via an androgen response element localized in the distal promoter region of the GPX5 gene [6].
  • Because of the lack of selenium (Se) in the active site of this enzyme, unlike the other animal GPXs characterized to date, it was suspected that GPX5 does not function in the epididymis as a true glutathione peroxidase in vivo [7].
  • The major androgen-regulated secretory proteins of the rat epididymis bear sequence homology with members of the alpha 2u-globulin superfamily [8].

Anatomical context of Gpx5

  • Gpx5 was shown to be epididymis specific and restricted to the caput epididymidis, while gpx3 was found to be expressed in a wide array of tissues including the caput, corpus and cauda epididymides [9].
  • Unlike in the mouse model, bovine GPX5 seems to be poorly secreted and does not seem to be present on cauda epididymal spermatozoa [10].

Associations of Gpx5 with chemical compounds

  • Selenium-independent epididymis-restricted glutathione peroxidase 5 protein (GPX5) can back up failing Se-dependent GPXs in mice subjected to selenium deficiency [7].

Analytical, diagnostic and therapeutic context of Gpx5


  1. Immortalization of epididymal epithelium in transgenic mice expressing simian virus 40 T antigen: characterization of cell lines and regulation of the polyoma enhancer activator 3. Sipilä, P., Shariatmadari, R., Huhtaniemi, I.T., Poutanen, M. Endocrinology (2004) [Pubmed]
  2. ACTH induces up-regulation of ACTH receptor mRNA in mouse and human adrenocortical cell lines. Mountjoy, K.G., Bird, I.M., Rainey, W.E., Cone, R.D. Mol. Cell. Endocrinol. (1994) [Pubmed]
  3. Structural organization and regulation of the gene for the androgen-dependent glutathione peroxidase-like protein specific to the mouse epididymis. Ghyselinck, N.B., Dufaure, I., Lareyre, J.J., Rigaudière, N., Mattéi, M.G., Dufaure, J.P. Mol. Endocrinol. (1993) [Pubmed]
  4. Cloning, sequencing, and characterization of the murine nm23-M5 gene during mouse spermatogenesis and spermiogenesis. Hwang, K.C., Ok, D.W., Hong, J.C., Kim, M.O., Kim, J.H. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  5. The PEA3 protein of the Ets oncogene family is a putative transcriptional modulator of the mouse epididymis-specific glutathione peroxidase gene gpx5. Drevet, J.R., Lareyre, J.J., Schwaab, V., Vernet, P., Dufaure, J.P. Mol. Reprod. Dev. (1998) [Pubmed]
  6. Characterization of an androgen response element within the promoter of the epididymis-specific murine glutathione peroxidase 5 gene. Lareyre, J.J., Claessens, F., Rombauts, W., Dufaure, J.P., Drevet, J.R. Mol. Cell. Endocrinol. (1997) [Pubmed]
  7. Selenium-independent epididymis-restricted glutathione peroxidase 5 protein (GPX5) can back up failing Se-dependent GPXs in mice subjected to selenium deficiency. Vernet, P., Rock, E., Mazur, A., Rayssiguier, Y., Dufaure, J.P., Drevet, J.R. Mol. Reprod. Dev. (1999) [Pubmed]
  8. The major androgen-regulated secretory proteins of the rat epididymis bear sequence homology with members of the alpha 2u-globulin superfamily. Brooks, D.E. Biochem. Int. (1987) [Pubmed]
  9. Characterization, regulation of the expression and putative roles of two glutathione peroxidase proteins found in the mouse epididymis. Schwaab, V., Lareyre, J.J., Vernet, P., Pons, E., Faure, J., Dufaure, J.P., Drevet, J.R. J. Reprod. Fertil. Suppl. (1998) [Pubmed]
  10. GPX5 orthologs of the mouse epididymis-restricted and sperm-bound selenium-independent glutathione peroxidase are not expressed with the same quantitative and spatial characteristics in large domestic animals. Grignard, E., Morin, J., Vernet, P., Drevet, J.R. Theriogenology (2005) [Pubmed]
  11. Molecular cloning and characterization of the epididymis-specific glutathione peroxidase-like protein secreted in the porcine epididymal fluid. Okamura, N., Iwaki, Y., Hiramoto, S., Tamba, M., Bannai, S., Sugita, Y., Syntin, P., Dacheux, F., Dacheux, J.L. Biochim. Biophys. Acta (1997) [Pubmed]
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