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Gene Review

CREB3L4  -  cAMP responsive element binding protein 3...

Homo sapiens

Synonyms: AIBZIP, AIbZIP, ATCE1, Androgen-induced basic leucine zipper protein, Attaching to CRE-like 1, ...
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Disease relevance of CREB3L4


High impact information on CREB3L4


Chemical compound and disease context of CREB3L4

  • Comparison of the mRNA expression profiles of control and R1881-treated cultures of LNCaP human prostate cancer cells using cDNA subtraction led to the identification of a novel transcription factor that we named Androgen-Induced bZIP (AIbZIP) protein [1].

Biological context of CREB3L4


Anatomical context of CREB3L4

  • Each factor localizes to the endoplasmic reticulum (ER), but a population of CREB4 was also observed in the Golgi [7].
  • The expression pattern of the human CREB4 gene showed transcripts in prostate, brain, pancreas, skeletal muscle, small intestine, testis, leukocyte, and thymus, whereas in heart, lung, liver, kidney, placenta, spleen, ovary, and colon, specific bands of the transcript could not be detected [5].
  • A developmental study using Northern hybridization and in situ hybridization analyses revealed that Atce1 transcripts begin to accumulate in testes of mice 24 d after birth, reflecting expression in mid/late round spermatids [8].
  • Atce1: a novel mouse cyclic adenosine 3',5'-monophosphate-responsive element-binding protein-like gene exclusively expressed in postmeiotic spermatids [8].
  • Expression of full-length ATCE1 in various cell lines revealed ER and Golgi localization whereas truncation of the C-terminus allowed entrance into the nucleus [6].

Associations of CREB3L4 with chemical compounds

  • Dithiothreitol induced more complete transport of CREB4 to the Golgi, but not cleavage [7].
  • CREB4 was cleaved in a site-specific manner in response to brefeldin A disruption of the Golgi or by coexpression with S1P but only after deletion or substitution of its C-terminal lumenal domain [7].

Other interactions of CREB3L4

  • Thus, S1P cleavage of CREB4 may be suppressed by a determinant in the C-terminal region [7].

Analytical, diagnostic and therapeutic context of CREB3L4

  • In contrast to CREB3L4 in the human prostate, of which specific expression was detected, Creb3l4 transcripts in the mouse prostate could be detected only by RT-PCR [9].
  • Examination of AIbZIP protein and mRNA expression in a series of transurethral resection of the prostate and needle biopsy specimens indicated that AIbZIP is expressed at higher levels in cancerous prostate cells compared with noncancerous prostate cells [1].
  • Molecular cloning and characterization of a novel human cAMP response element-binding ( CREB) gene ( CREB4) [5].


  1. AIbZIP, a novel bZIP gene located on chromosome 1q21.3 that is highly expressed in prostate tumors and of which the expression is up-regulated by androgens in LNCaP human prostate cancer cells. Qi, H., Fillion, C., Labrie, Y., Grenier, J., Fournier, A., Berger, L., El-Alfy, M., Labrie, C. Cancer Res. (2002) [Pubmed]
  2. Expression pattern and preliminary functional analysis of human CREB4 gene. Gao, Y.J., Cao, G.T., Yin, G., Wang, X., Ji, C.N., Gu, S.H., Ni, X.H. Yi Chuan Xue Bao (2005) [Pubmed]
  3. Evaluation of AIbZIP and Cdc47 as markers for human prostatic diseases. Levesque, M.H., El-Alfy, M., Berger, L., Labrie, F., Labrie, C. Urology (2007) [Pubmed]
  4. Fusion of the FUS and BBF2H7 genes in low grade fibromyxoid sarcoma. Storlazzi, C.T., Mertens, F., Nascimento, A., Isaksson, M., Wejde, J., Brosjo, O., Mandahl, N., Panagopoulos, I. Hum. Mol. Genet. (2003) [Pubmed]
  5. Molecular cloning and characterization of a novel human cAMP response element-binding ( CREB) gene ( CREB4). Cao, G., Ni, X., Jiang, M., Ma, Y., Cheng, H., Guo, L., Ji, C., Gu, S., Xie, Y., Mao, Y. J. Hum. Genet. (2002) [Pubmed]
  6. The enigma of ATCE1, an acrosome-associated transcription factor. Gil, S., Yosef, D., Golan, N., Don, J. Dev. Biol. (2006) [Pubmed]
  7. CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P. Stirling, J., O'hare, P. Mol. Biol. Cell (2006) [Pubmed]
  8. Atce1: a novel mouse cyclic adenosine 3',5'-monophosphate-responsive element-binding protein-like gene exclusively expressed in postmeiotic spermatids. Stelzer, G., Don, J. Endocrinology (2002) [Pubmed]
  9. Reduction of spermatogenesis but not fertility in Creb3l4-deficient mice. Adham, I.M., Eck, T.J., Mierau, K., Müller, N., Sallam, M.A., Paprotta, I., Schubert, S., Hoyer-Fender, S., Engel, W. Mol. Cell. Biol. (2005) [Pubmed]
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