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Gene Review

H2afx  -  H2A histone family, member X

Mus musculus

Synonyms: AW228881, H2A.X, H2a.x, H2a/x, H2ax, ...
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  • The tryptic peptide patterns of the recently described H2A species H2A.X and H2A.Z from mouse were compared with the tryptic peptide patterns of the major mouse H2A's, H2A.1 and H2A [9].


  1. AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching. Petersen, S., Casellas, R., Reina-San-Martin, B., Chen, H.T., Difilippantonio, M.J., Wilson, P.C., Hanitsch, L., Celeste, A., Muramatsu, M., Pilch, D.R., Redon, C., Ried, T., Bonner, W.M., Honjo, T., Nussenzweig, M.C., Nussenzweig, A. Nature (2001) [Pubmed]
  2. Polyadenylated and 3' processed mRNAs are transcribed from the mouse histone H2A.X gene. Nagata, T., Kato, T., Morita, T., Nozaki, M., Kubota, H., Yagi, H., Matsushiro, A. Nucleic Acids Res. (1991) [Pubmed]
  3. Identification of histone H2A.X as a growth factor secreted by an androgen-independent subline of mouse mammary carcinoma cells. Watabe, Y., Kuramochi, H., Furuya, Y., Inagaki, N., Seino, S., Kimura, S., Shimazaki, J. J. Biol. Chem. (1996) [Pubmed]
  4. Hyperphosphorylation of histone H2A.X and dephosphorylation of histone H1 subtypes in the course of apoptosis. Talasz, H., Helliger, W., Sarg, B., Debbage, P.L., Puschendorf, B., Lindner, H. Cell Death Differ. (2002) [Pubmed]
  5. Regulation of the mouse histone H2A.X gene promoter by the transcription factor E2F and CCAAT binding protein. Yagi, H., Kato, T., Nagata, T., Habu, T., Nozaki, M., Matsushiro, A., Nishimune, Y., Morita, T. J. Biol. Chem. (1995) [Pubmed]
  6. Structure of the mouse H2A.X gene and physical linkage to the UPS locus on chromosome 9: assignment of the human H2A.X gene to 11q23 by sequence analysis. Porcher, C., Grandchamp, B. Genomics (1995) [Pubmed]
  7. Characterization of histone H2A.X expression in testis and specific labeling of germ cells at the commitment stage of meiosis with histone H2A.X promoter-enhanced green fluorescent protein transgene. Tadokoro, Y., Yomogida, K., Yagura, Y., Yamada, S., Okabe, M., Nishimune, Y. Biol. Reprod. (2003) [Pubmed]
  8. Histone 2A, a heteromorphous family of eight protein species. West, M.H., Bonner, W.M. Biochemistry (1980) [Pubmed]
  9. Structural comparisons of mouse histones 2A.X and 2A.Z with 2A.1 and 2A.2. West, M.H., Bonner, W.M. Comp. Biochem. Physiol., B (1983) [Pubmed]
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