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Gene Review

Lhx5  -  LIM homeobox protein 5

Mus musculus

Synonyms: LIM/homeobox protein Lhx5, Lim2
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High impact information on Lhx5


Biological context of Lhx5


Anatomical context of Lhx5

  • By midgestation, both genes, Lhx5 and Dlx5, are expressed in the diencephalon and ventral telencephalon in an alternating complementary pattern [3].
  • During development its domain of expression is mainly localized at the most anterior portion of the neural tube, and it precedes the morphological differentiation of the forebrain; for this reason we believe that Lhx5 could play an important role in forebrain patterning [4].

Other interactions of Lhx5

  • Lhx5 expression is detected in the most anterior portion of the neural tube at the headfold stage, overlapping partially with Otx2 expression domain [3].


  1. Control of hippocampal morphogenesis and neuronal differentiation by the LIM homeobox gene Lhx5. Zhao, Y., Sheng, H.Z., Amini, R., Grinberg, A., Lee, E., Huang, S., Taira, M., Westphal, H. Science (1999) [Pubmed]
  2. Lhx1 and Lhx5 maintain the inhibitory-neurotransmitter status of interneurons in the dorsal spinal cord. Pillai, A., Mansouri, A., Behringer, R., Westphal, H., Goulding, M. Development (2007) [Pubmed]
  3. Expression of murine Lhx5 suggests a role in specifying the forebrain. Sheng, H.Z., Bertuzzi, S., Chiang, C., Shawlot, W., Taira, M., Dawid, I., Westphal, H. Dev. Dyn. (1997) [Pubmed]
  4. Molecular cloning, structure, and chromosomal localization of the mouse LIM/homeobox gene Lhx5. Bertuzzi, S., Sheng, H.Z., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Taira, M., Dawid, I.B., Westphal, H. Genomics (1996) [Pubmed]
  5. Learning impairments and motor dysfunctions in adult Lhx5-deficient mice displaying hippocampal disorganization. Paylor, R., Zhao, Y., Libbey, M., Westphal, H., Crawley, J.N. Physiol. Behav. (2001) [Pubmed]
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