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Gene Review

Asic3  -  acid-sensing (proton-gated) ion channel 3

Mus musculus

Synonyms: ASIC3, AW742291, Accn3, Acid-sensing ion channel 3, Amiloride-sensitive cation channel 3, ...
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Disease relevance of Accn3


High impact information on Accn3

  • The data suggest that DRASIC subunits participate in heteromultimeric channel complexes in sensory neurons [3].
  • We localized one such channel, DRASIC, in several different specialized sensory nerve endings of skin, suggesting it might participate in mechanosensation and/or acid-evoked nociception [3].
  • Loss of DRASIC increased the sensitivity of mechanoreceptors detecting light touch, but it reduced the sensitivity of a mechanoreceptor responding to noxious pinch and decreased the response of acid- and noxious heat-sensitive nociceptors [3].
  • The biophysical properties of three degenerin/epithelial sodium (DEG/ENaC) channel subunits (BNC1, ASIC, and DRASIC), and their expression in DRG, suggest that they might underlie these H(+)-gated currents and function as sensory transducers [4].
  • CONCLUSIONS: These data show that ASIC3 makes a critical positive contribution to mechanosensitivity in three out of four classes of visceral afferents [5].

Biological context of Accn3

  • No differences in current amplitude or kinetics were found between ASIC2 and/or ASIC3 null mutants and controls [6].

Anatomical context of Accn3


Associations of Accn3 with chemical compounds

  • We found that neuropeptide FF (Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe amide) and FMRFamide (Phe-Met-Arg-Phe amide) generated no current on their own but potentiated H+-gated currents from cultured sensory neurons and heterologously expressed ASIC and DRASIC channels [8].
  • We show here that serine proteases modulate the function of ASIC1a and ASIC1b but not of ASIC2a and ASIC3 [9].

Other interactions of Accn3

  • In particular ASIC3, the least abundant in the general population, is the most abundant ASIC transcript in colonic neurons [10].
  • QPCR of whole thoracolumbar DRG revealed and abundance of ASIC2 > ASIC1 > ASIC3 [10].

Analytical, diagnostic and therapeutic context of Accn3

  • By RT-PCR, one clone similar to the mouse Asic3 cDNA (proton-gated channel) was found mainly in the retina and cochlea, but its human ortholog was widely expressed [11].


  1. Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1. Sluka, K.A., Price, M.P., Breese, N.M., Stucky, C.L., Wemmie, J.A., Welsh, M.J. Pain (2003) [Pubmed]
  2. Characterisation of DRASIC in the mouse inner ear. Hildebrand, M.S., de Silva, M.G., Klockars, T., Rose, E., Price, M., Smith, R.J., McGuirt, W.T., Christopoulos, H., Petit, C., Dahl, H.H. Hear. Res. (2004) [Pubmed]
  3. The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice. Price, M.P., McIlwrath, S.L., Xie, J., Cheng, C., Qiao, J., Tarr, D.E., Sluka, K.A., Brennan, T.J., Lewin, G.R., Welsh, M.J. Neuron (2001) [Pubmed]
  4. Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neurons. Benson, C.J., Xie, J., Wemmie, J.A., Price, M.P., Henss, J.M., Welsh, M.J., Snyder, P.M. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  5. Different contributions of ASIC channels 1a, 2, and 3 in gastrointestinal mechanosensory function. Page, A.J., Brierley, S.M., Martin, C.M., Price, M.P., Symonds, E., Butler, R., Wemmie, J.A., Blackshaw, L.A. Gut (2005) [Pubmed]
  6. Acid-sensing ion channels ASIC2 and ASIC3 do not contribute to mechanically activated currents in mammalian sensory neurones. Drew, L.J., Rohrer, D.K., Price, M.P., Blaver, K.E., Cockayne, D.A., Cesare, P., Wood, J.N. J. Physiol. (Lond.) (2004) [Pubmed]
  7. ASIC3 and ASIC1 mediate FMRFamide-related peptide enhancement of H+-gated currents in cultured dorsal root ganglion neurons. Xie, J., Price, M.P., Wemmie, J.A., Askwith, C.C., Welsh, M.J. J. Neurophysiol. (2003) [Pubmed]
  8. Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels. Askwith, C.C., Cheng, C., Ikuma, M., Benson, C., Price, M.P., Welsh, M.J. Neuron (2000) [Pubmed]
  9. Selective regulation of acid-sensing ion channel 1 by serine proteases. Poirot, O., Vukicevic, M., Boesch, A., Kellenberger, S. J. Biol. Chem. (2004) [Pubmed]
  10. Localization and comparative analysis of acid-sensing ion channel (ASIC1, 2, and 3) mRNA expression in mouse colonic sensory neurons within thoracolumbar dorsal root ganglia. Hughes, P.A., Brierley, S.M., Young, R.L., Blackshaw, L.A. J. Comp. Neurol. (2007) [Pubmed]
  11. Identification of preferentially expressed mRNAs in retina and cochlea. Maubaret, C., Delettre, C., Sola, S., Hamel, C.P. DNA Cell Biol. (2002) [Pubmed]
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