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Gene Review

Msmb  -  beta-microseminoprotein

Mus musculus

Synonyms: Beta-microseminoprotein, PIP, PSP-94, PSP94, Prostate secreted seminal plasma protein, ...
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Disease relevance of Msmb

  • In view of the limitations of transgenic technique-derived CaP models, herein we report the first application of knockin technology to establish a new mouse adenocarcinoma prostate model (PSP-KIMAP) by targeting of SV40 Tag to a prostate tissue-specific gene, PSP94 (prostate secretory protein of 94 amino acids) [1].
  • Quantified serum levels of mouse PSP94 ranged from 49.84 ng/mL in wild-type mice to 113.86, 400.45, and 930.90 ng/mL in mouse prostatic intraepithelial neoplasia with microinvasion, well differentiated, moderately differentiated, and poorly differentiated prostate cancer genetically engineered prostate cancer mice, respectively (P < 0.01, n = 68) [2].
  • Using recombinant GST fusion protein with PSP94 and with each half of the N- and C-terminal 47 amino acids (GST-PSP-N47/C47) in E. coli cells, the different epitopes recognized by 15 monoclonal antibodies were delineated and the polar distribution of the epitope structure of PSP94 was characterized [3].

High impact information on Msmb

  • The differences between the two CaP models were attributed to the introduction of a single endogenous knockin mutation, resulting in a CaP model self-regulated and controlled by a prostate gene promoter/enhancer of PSP94 [1].
  • In order to demonstrate its novelty, we compared KIMAP to a PSP94 gene-directed transgenic mouse adenocarcinoma of the prostate (PSP-TGMAP) model [1].
  • Immunohistochemistry studies on different histologic grades from both transgenic and knock-in mouse prostate cancer models showed the down-regulation of tissue PSP94 expression (P < 0.001), the same as for PSA and PSP94 in humans [2].
  • Through longitudinal monitoring of serum PSP94 levels of castrated mice (androgen ablation therapy), we found a correlation between responsiveness/refractory prostate tissues and serum PSP94 levels [2].
  • Firstly, a series of progressive deletion mutants of a 3.84 kb PSP94 gene promoter/enhancer region (including parts of the intron 1 sequence) linked with a reporter LacZ gene was constructed and assessed in vitro in cell culture [4].

Chemical compound and disease context of Msmb

  • Since most rat prostate dysplasia induced by steroid hormone treatment occurs only in dorsolateral prostate, prostate tissue-specific expression and the expression of PSP94 in dorsolateral, but not other, lobes of the prostate suggest a potential role in prostate targeting and prostate cancer development [5].

Biological context of Msmb


Anatomical context of Msmb


Other interactions of Msmb

  • Comparing with alpha-globin, a typical evolutionally conserved gene, with the PSP94 gene, the rate of nonsynonymous changes per site per year (kN) is 2 to 6 times higher, indicating that PSP94 gene has been under far fewer evolutionary constraints than other genes and has a potential role as a species barrier in reproductive biology [8].
  • TCDD reduced dorsolateral prostate weight in wild-type but not AhRKO mice and had no significant effect on expression of mRNA for PSP94 or for probasin, a major androgen-dependent secretory protein [11].

Analytical, diagnostic and therapeutic context of Msmb


  1. Knockin of SV40 Tag oncogene in a mouse adenocarcinoma of the prostate model demonstrates advantageous features over the transgenic model. Duan, W., Gabril, M.Y., Moussa, M., Chan, F.L., Sakai, H., Fong, G., Xuan, J.W. Oncogene (2005) [Pubmed]
  2. Establishment of a serum tumor marker for preclinical trials of mouse prostate cancer models. Huizen, I.V., Wu, G., Moussa, M., Chin, J.L., Fenster, A., Lacefield, J.C., Sakai, H., Greenberg, N.M., Xuan, J.W. Clin. Cancer Res. (2005) [Pubmed]
  3. Analysis of epitope structure of PSP94 (prostate secretory protein of 94 amino acids): (II). Epitope mapping by monoclonal antibodies. Xuan, J.W., Wu, D., Guo, Y., Huang, C.L., Wright, G.L., Chin, J.L. J. Cell. Biochem. (1997) [Pubmed]
  4. Prostate targeting: PSP94 gene promoter/enhancer region directed prostate tissue-specific expression in a transgenic mouse prostate cancer model. Gabril, M.Y., Onita, T., Ji, P.G., Sakai, H., Chan, F.L., Koropatnick, J., Chin, J.L., Moussa, M., Xuan, J.W. Gene Ther. (2002) [Pubmed]
  5. Differential expression of PSP94 in rat prostate lobes as demonstrated by an antibody against recombinant GST-PSP94. Kwong, J., Chan, F.L., Jiang, S., Guo, Y., Imasato, Y., Sakai, H., Koropatnick, J., Chin, J.L., Xuan, J.W. J. Cell. Biochem. (1999) [Pubmed]
  6. Disulfide pairings and secondary structure of porcine beta-microseminoprotein. Wang, I., Yu, T.A., Wu, S.H., Chang, W.C., Chen, C. FEBS Lett. (2003) [Pubmed]
  7. Mouse PSP94 expression is prostate tissue-specific as demonstrated by a comparison of multiple antibodies against recombinant proteins. Thota, A., Karajgikar, M., Duan, W., Gabril, M.Y., Chan, F.L., Wong, Y.C., Sakai, H., Chin, J.L., Moussa, M., Xuan, J.W. J. Cell. Biochem. (2003) [Pubmed]
  8. cDNA, genomic cloning, and gene expression analysis of mouse PSP94 (prostate secretory protein of 94 amino acids). Xuan, J.W., Kwong, J., Chan, F.L., Ricci, M., Imasato, Y., Sakai, H., Fong, G.H., Panchal, C., Chin, J.L. DNA Cell Biol. (1999) [Pubmed]
  9. Antiproliferative action of prostatic inhibin on NRK-49F and BALB/c 3T3 cell lines. Mundle, S.D., Rao, S.G., Sheth, N.A. Cell Biol. Int. Rep. (1992) [Pubmed]
  10. Suppression of steroidogenesis in mice granulosa cells by a synthetic nonapeptide fragment of human seminal plasma inhibin. Hurkadli, K.S., Shahid, J.K., Nandedkar, T.D., Mahale, S.D., Iyer, K.S., Sheth, A.R. Indian J. Exp. Biol. (1991) [Pubmed]
  11. Effects of aryl hydrocarbon receptor null mutation and in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on prostate and seminal vesicle development in C57BL/6 mice. Lin, T.M., Ko, K., Moore, R.W., Simanainen, U., Oberley, T.D., Peterson, R.E. Toxicol. Sci. (2002) [Pubmed]
  12. Assignment of the human gene for beta-microseminoprotein (MSMB) to chromosome 10 and demonstration of related genes in other vertebrates. Ulvsbäck, M., Spurr, N.K., Lundwall, A. Genomics (1991) [Pubmed]
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