Gene Review:
SEC1 - Sec1p
Saccharomyces cerevisiae S288c
Synonyms:
Protein transport protein SEC1, YD8358.18C, YDR164C
- Mutations in VPS33B, encoding a regulator of SNARE-dependent membrane fusion, cause arthrogryposis-renal dysfunction-cholestasis (ARC) syndrome. Gissen, P., Johnson, C.A., Morgan, N.V., Stapelbroek, J.M., Forshew, T., Cooper, W.N., McKiernan, P.J., Klomp, L.W., Morris, A.A., Wraith, J.E., McClean, P., Lynch, S.A., Thompson, R.J., Lo, B., Quarrell, O.W., Di Rocco, M., Trembath, R.C., Mandel, H., Wali, S., Karet, F.E., Knisely, A.S., Houwen, R.H., Kelly, D.A., Maher, E.R. Nat. Genet. (2004)
- A rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles. Søgaard, M., Tani, K., Ye, R.R., Geromanos, S., Tempst, P., Kirchhausen, T., Rothman, J.E., Söllner, T. Cell (1994)
- Mutations in the Drosophila Rop gene suggest a function in general secretion and synaptic transmission. Harrison, S.D., Broadie, K., van de Goor, J., Rubin, G.M. Neuron (1994)
- The Sec1p/Munc18 protein Vps45p binds its cognate SNARE proteins via two distinct modes. Carpp, L.N., Ciufo, L.F., Shanks, S.G., Boyd, A., Bryant, N.J. J. Cell Biol. (2006)
- Functional specialization within a vesicle tethering complex: bypass of a subset of exocyst deletion mutants by Sec1p or Sec4p. Wiederkehr, A., De Craene, J.O., Ferro-Novick, S., Novick, P. J. Cell Biol. (2004)
- Mutations in the VPS45 gene, a SEC1 homologue, result in vacuolar protein sorting defects and accumulation of membrane vesicles. Cowles, C.R., Emr, S.D., Horazdovsky, B.F. J. Cell. Sci. (1994)
- Cloning and sequencing of the yeast Saccharomyces cerevisiae SEC1 gene localized on chromosome IV. Aalto, M.K., Ruohonen, L., Hosono, K., Keränen, S. Yeast (1991)
- Molecular interactions position Mso1p, a novel PTB domain homologue, in the interface of the exocyst complex and the exocytic SNARE machinery in yeast. Knop, M., Miller, K.J., Mazza, M., Feng, D., Weber, M., Keränen, S., Jäntti, J. Mol. Biol. Cell (2005)
- The effects of clathrin inactivation on localization of Kex2 protease are independent of the TGN localization signal in the cytosolic tail of Kex2p. Redding, K., Seeger, M., Payne, G.S., Fuller, R.S. Mol. Biol. Cell (1996)
- Mso1p: a yeast protein that functions in secretion and interacts physically and genetically with Sec1p. Aalto, M.K., Jäntti, J., Ostling, J., Keränen, S., Ronne, H. Proc. Natl. Acad. Sci. U.S.A. (1997)
- The Sec1/Munc18 protein, Vps33p, functions at the endosome and the vacuole of Saccharomyces cerevisiae. Subramanian, S., Woolford, C.A., Jones, E.W. Mol. Biol. Cell (2004)
- An Arabidopsis VPS45p homolog implicated in protein transport to the vacuole. Bassham, D.C., Raikhel, N.V. Plant Physiol. (1998)
- A conditional sterol esterification defect in yeast having either a sec1 or sec5 mutation in the secretory pathway. Tomeo, M.E., Palermo, L.M., Tove, S., Parks, L.W. Yeast (1997)
- t-SNARE activation through transient interaction with a rab-like guanosine triphosphatase. Lupashin, V.V., Waters, M.G. Science (1997)
- Vac1p coordinates Rab and phosphatidylinositol 3-kinase signaling in Vps45p-dependent vesicle docking/fusion at the endosome. Peterson, M.R., Burd, C.G., Emr, S.D. Curr. Biol. (1999)
- The phosphatidylinositol 3-phosphate binding protein Vac1p interacts with a Rab GTPase and a Sec1p homologue to facilitate vesicle-mediated vacuolar protein sorting. Tall, G.G., Hama, H., DeWald, D.B., Horazdovsky, B.F. Mol. Biol. Cell (1999)
- Cytoplasm to vacuole trafficking of aminopeptidase I requires a t-SNARE-Sec1p complex composed of Tlg2p and Vps45p. Abeliovich, H., Darsow, T., Emr, S.D. EMBO J. (1999)
- Sly1 protein bound to Golgi syntaxin Sed5p allows assembly and contributes to specificity of SNARE fusion complexes. Peng, R., Gallwitz, D. J. Cell Biol. (2002)
- Interactions of the Trichoderma reesei rho3 with the secretory pathway in yeast and T. reesei. Vasara, T., Salusjärvi, L., Raudaskoski, M., Keränen, S., Penttilä, M., Saloheimo, M. Mol. Microbiol. (2001)
- Mso1 is a novel component of the yeast exocytic SNARE complex. Castillo-Flores, A., Weinberger, A., Robinson, M., Gerst, J.E. J. Biol. Chem. (2005)
- Prospore membrane formation defines a developmentally regulated branch of the secretory pathway in yeast. Neiman, A.M. J. Cell Biol. (1998)
- The Sec1 family: a novel family of proteins involved in synaptic transmission and general secretion. Halachmi, N., Lev, Z. J. Neurochem. (1996)
- Two new Ypt GTPases are required for exit from the yeast trans-Golgi compartment. Jedd, G., Mulholland, J., Segev, N. J. Cell Biol. (1997)
- A novel RING finger protein, Vps8p, functionally interacts with the small GTPase, Vps21p, to facilitate soluble vacuolar protein localization. Horazdovsky, B.F., Cowles, C.R., Mustol, P., Holmes, M., Emr, S.D. J. Biol. Chem. (1996)
- Multicopy suppressors of the sly1 temperature-sensitive mutation in the ER-Golgi vesicular transport in Saccharomyces cerevisiae. Kosodo, Y., Imai, K., Hirata, A., Noda, Y., Takatsuki, A., Adachi, H., Yoda, K. Yeast (2001)
- Sec1p directly stimulates SNARE-mediated membrane fusion in vitro. Scott, B.L., Van Komen, J.S., Irshad, H., Liu, S., Wilson, K.A., McNew, J.A. J. Cell Biol. (2004)
- Characterization of the sec1-1 and sec1-11 mutations. Brummer, M.H., Kivinen, K.J., Jäntti, J., Toikkanen, J., Söderlund, H., Keränen, S. Yeast (2001)
- Increased expression of the SNARE accessory protein Munc18c in lipid-mediated insulin resistance. Schlaepfer, I.R., Pulawa, L.K., Ferreira, L.D., James, D.E., Capell, W.H., Eckel, R.H. J. Lipid Res. (2003)
- Cytochemical evaluation of localization and secretion of a heterologous enzyme displayed on yeast cell surface. Shibasaki, Y., Kamasawa, N., Shibasaki, S., Zou, W., Murai, T., Ueda, M., Tanaka, A., Osumi, M. FEMS Microbiol. Lett. (2000)