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Gene Review

Pcm1  -  pericentriolar material 1

Mus musculus

Synonyms: 2600002H09Rik, 9430077F19Rik, C030044G17Rik, PCM-1, Pericentriolar material 1 protein, ...
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Disease relevance of Pcm1


High impact information on Pcm1

  • Centrosome development in early mouse embryos as defined by an autoantibody against pericentriolar material [2].
  • During this time PCM was found assembled at a single locus in the cell and exclusively in mitotic cells; it was not observable in interphase cells [2].
  • Using a GFP fusion protein with PCM-1, we found that PCM-1-containing centriolar satellites moved along microtubules toward their minus ends, i.e., toward centrosomes, in live cells, as well as in vitro reconstituted asters [3].
  • These findings suggested that centriolar satellites and fibrous granules are identical novel nonmembranous organelles containing PCM-1, which may play some important role(s) in centriolar replication [3].
  • Next, to understand the relationship between centriolar satellites and centriolar replication, we examined the expression and subcellular localization of PCM-1 in ciliated epithelial cells during ciliogenesis [3].

Biological context of Pcm1


Anatomical context of Pcm1


Other interactions of Pcm1


Analytical, diagnostic and therapeutic context of Pcm1


  1. Effects of taxol and taxol/hyperthermia treatments on the functional polarization of cytotoxic T lymphocytes. Knox, J.D., Mitchel, R.E., Brown, D.L. Cell Motil. Cytoskeleton (1993) [Pubmed]
  2. Centrosome development in early mouse embryos as defined by an autoantibody against pericentriolar material. Calarco-Gillam, P.D., Siebert, M.C., Hubble, R., Mitchison, T., Kirschner, M. Cell (1983) [Pubmed]
  3. Centriolar satellites: molecular characterization, ATP-dependent movement toward centrioles and possible involvement in ciliogenesis. Kubo, A., Sasaki, H., Yuba-Kubo, A., Tsukita, S., Shiina, N. J. Cell Biol. (1999) [Pubmed]
  4. Redistribution of microtubules and pericentriolar material during the development of polarity in mouse blastomeres. Houliston, E., Pickering, S.J., Maro, B. J. Cell Biol. (1987) [Pubmed]
  5. The effect of dimethylsulphoxide on the microtubular system of the mouse oocyte. Johnson, M.H., Pickering, S.J. Development (1987) [Pubmed]
  6. Microtubule organization and distribution of gamma-tubulin in male meiosis of lepidoptera. Wolf, K.W., Joshi, H.C. Mol. Reprod. Dev. (1996) [Pubmed]
  7. Centrosome inheritance after fertilization and nuclear transfer in mammals. Sun, Q.Y., Schatten, H. Adv. Exp. Med. Biol. (2007) [Pubmed]
  8. inheritance of sperm centrioles and centrosomes in bovine embryos. Sathananthan, A.H., Tatham, B., Dharmawardena, V., Grills, B., Lewis, I., Trounson, A. Arch. Androl. (1997) [Pubmed]
  9. Microtubule-organizing centers abnormal in number, structure, and nucleating activity in x-irradiated mammalian cells. Sato, C., Kuriyama, R., Nishizawa, K. J. Cell Biol. (1983) [Pubmed]
  10. Bipolar meiotic spindle formation without chromatin. Brunet, S., Polanski, Z., Verlhac, M.H., Kubiak, J.Z., Maro, B. Curr. Biol. (1998) [Pubmed]
  11. Formation of two microtubule-nucleating sites which perform differently during centrosomal reorganization in a mouse cochlear epithelial cell. Tucker, J.B., Mogensen, M.M., Paton, C.C., Mackie, J.B., Henderson, C.G., Leckie, L.M. J. Cell. Sci. (1995) [Pubmed]
  12. Effects of hyperthermia on microtubule organization and cytolytic activity of murine cytotoxic T lymphocytes. Knox, J.D., Mitchel, R.E., Brown, D.L. Exp. Cell Res. (1991) [Pubmed]
  13. A protein related to brain microtubule-associated protein MAP1B is a component of the mammalian centrosome. Domínguez, J.E., Buendia, B., López-Otín, C., Antony, C., Karsenti, E., Avila, J. J. Cell. Sci. (1994) [Pubmed]
  14. Association of vimentin intermediate filaments with the centrosome. Trevor, K.T., McGuire, J.G., Leonova, E.V. J. Cell. Sci. (1995) [Pubmed]
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