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Gene Review

Serpinb9  -  serine (or cysteine) peptidase inhibitor,...

Mus musculus

Synonyms: BB283241, CAP-3, CAP3, PI-9, PI9, ...
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Disease relevance of Serpinb9

  • Spi6 KO mice in turn were impaired in their ability to clear LCMV infection [1].
  • In mouse models, both elevated expression of Spi6 and the complete absence of granzyme B in CD8+ T cells led to an increase in memory cells after infection with lymphocytic choriomeningitis virus [2].
  • In light of prior studies indicating that virally infected hepatocytes are selectively resistant to this CTL effector mechanism, the present studies investigated PI-9 and SPI-6 expression in hepatocytes and hepatoma cells in response to adenoviral infection and to cytokines produced during antiviral immune responses [3].

High impact information on Serpinb9

  • We conclude that Spi6 protects CTLs from suicide caused by GrB-mediated breakdown of cytotoxic granules [1].
  • We propose that expression of protective molecules, like Spi6, serves to shield metabolically active CD8+ memory T cells from their own effector molecules [2].
  • These findings indicate that cytokines that promote antiviral cytopathic responses also regulate expression of the cytoprotective molecules, PI-9 and SPI-6, in hepatocytes that are potential targets of CTL and NK effector mechanisms [3].
  • By RNA analysis only one of the two sequences resembling PI-9 (designated SPI6) is present in mouse lymphocytes while the other (a partial clone designated mBM2A) is predominantly in testis [4].
  • In a search for the murine equivalent of PI-9 we screened cDNA libraries, and performed reverse transcriptase-polymerase chain reaction on RNA isolated from leukocyte cell lines and from lymph nodes and spleens of allo-immunized mice [4].

Biological context of Serpinb9


Anatomical context of Serpinb9


Analytical, diagnostic and therapeutic context of Serpinb9


  1. Serine protease inhibitor 6 protects cytotoxic T cells from self-inflicted injury by ensuring the integrity of cytotoxic granules. Zhang, M., Park, S.M., Wang, Y., Shah, R., Liu, N., Murmann, A.E., Wang, C.R., Peter, M.E., Ashton-Rickardt, P.G. Immunity (2006) [Pubmed]
  2. A role for the granzyme B inhibitor serine protease inhibitor 6 in CD8+ memory cell homeostasis. Phillips, T., Opferman, J.T., Shah, R., Liu, N., Froelich, C.J., Ashton-Rickardt, P.G. J. Immunol. (2004) [Pubmed]
  3. Antiviral cytokines induce hepatic expression of the granzyme B inhibitors, proteinase inhibitor 9 and serine proteinase inhibitor 6. Barrie, M.B., Stout, H.W., Abougergi, M.S., Miller, B.C., Thiele, D.L. J. Immunol. (2004) [Pubmed]
  4. A new family of 10 murine ovalbumin serpins includes two homologs of proteinase inhibitor 8 and two homologs of the granzyme B inhibitor (proteinase inhibitor 9). Sun, J., Ooms, L., Bird, C.H., Sutton, V.R., Trapani, J.A., Bird, P.I. J. Biol. Chem. (1997) [Pubmed]
  5. Enhancement of DNA vaccine potency by coadministration of a tumor antigen gene and DNA encoding serine protease inhibitor-6. Kim, T.W., Hung, C.F., Boyd, D.A., He, L., Lin, C.T., Kaiserman, D., Bird, P.I., Wu, T.C. Cancer Res. (2004) [Pubmed]
  6. Estrogen induction of the granzyme B inhibitor, proteinase inhibitor 9, protects cells against apoptosis mediated by cytotoxic T lymphocytes and natural killer cells. Jiang, X., Orr, B.A., Kranz, D.M., Shapiro, D.J. Endocrinology (2006) [Pubmed]
  7. Isolation and characterization of genes expressed uniquely during appressorium formation by Colletotrichum gloeosporioides conidia induced by the host surface wax. Hwang, C.S., Kolattukudy, P.E. Mol. Gen. Genet. (1995) [Pubmed]
  8. Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction. Hirst, C.E., Buzza, M.S., Sutton, V.R., Trapani, J.A., Loveland, K.L., Bird, P.I. Mol. Hum. Reprod. (2001) [Pubmed]
  9. Cloning and characterization of Cbl-associated protein splicing isoforms. Zhang, M., Kimura, A., Saltiel, A.R. Mol. Med. (2003) [Pubmed]
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