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Gene Review

Tfcp2  -  transcription factor CP2

Mus musculus

Synonyms: Alpha-globin transcription factor CP2, CP-2, CP2, D230015P20Rik, LBP-1c, ...
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Disease relevance of Tcfcp2


High impact information on Tcfcp2

  • Erythroid cell-specific alpha-globin gene regulation by the CP2 transcription factor family [3].
  • CP2b has an erythroid cell-specific transcriptional activation domain, which requires the extra exon and can form heteromeric complexes with other CP2 isoforms, but lacks the DNA binding activity found in CP2a and CP2c [3].
  • LBP-1a and CP2 are ubiquitously expressed members of the grainyhead transcription factor family, sharing significant sequence homology, a common DNA binding motif, and modulating a range of key regulatory and structural genes [4].
  • Here, we show that a grainyhead-related transcription factor, CP2-like 1 (CP2L1), is required for the maturation of the ducts of the salivary gland and kidney [5].
  • When murine bone marrow cells were treated with 5-FU plus LSF, release of this inhibitor of CFU-GM proliferation was blocked [2].

Biological context of Tcfcp2


Anatomical context of Tcfcp2


Associations of Tcfcp2 with chemical compounds

  • We tested the effect of LSF (100 mg/kg i.p., b.i.d.) on multilineage regeneration after high-dose 5-FU or thiotepa treatment in BALB/c mice [2].
  • METHODS: Based on a median split of sucrose intake during a final 1-h feeding test session, male Wistar rats were designated as either low (LSF) or high sucrose feeders (HSF) [10].
  • Lisofylline [(R)-1-(5-hydroxyhexyl)-3,7-dimethylxanthine; LSF] selectively inhibits generation of selected species of PA in P388 cells induced by TNF alpha, IL-1 beta or LPS [11].

Other interactions of Tcfcp2

  • We recently cloned human and murine cDNAs that encode CP2, a transcription factor that interacts with the murine alpha-globin promoter [6].

Analytical, diagnostic and therapeutic context of Tcfcp2

  • Sequence analysis of the proximal promoter region revealed several potential regulatory elements; these include the recognition elements of Sp1, Nkx, CP2, E2A, SIF (SIS-inducible factor), TFII-I and cAMP-responsive element (CRE), but no TATA sequences [12].
  • RESULTS: Data from this experiment revealed augmented responding in HSF compared with LSF during acquisition of amphetamine self-administration [10].
  • LSF has a marked protective effect in a variety of acute inflammatory animal models that may be due to inhibition of this shared second messenger pathway involving PA [11].


  1. A nuclear factor (NF2d9) that binds to the male-specific P450 (Cyp 2d-9) gene in mouse liver. Sueyoshi, T., Kobayashi, R., Nishio, K., Aida, K., Moore, R., Wada, T., Handa, H., Negishi, M. Mol. Cell. Biol. (1995) [Pubmed]
  2. Lisofylline inhibits transforming growth factor beta release and enhances trilineage hematopoietic recovery after 5-fluorouracil treatment in mice. Clarke, E., Rice, G.C., Weeks, R.S., Jenkins, N., Nelson, R., Bianco, J.A., Singer, J.W. Cancer Res. (1996) [Pubmed]
  3. Erythroid cell-specific alpha-globin gene regulation by the CP2 transcription factor family. Kang, H.C., Chae, J.H., Lee, Y.H., Park, M.A., Shin, J.H., Kim, S.H., Ye, S.K., Cho, Y.S., Fiering, S., Kim, C.G. Mol. Cell. Biol. (2005) [Pubmed]
  4. Defective extraembryonic angiogenesis in mice lacking LBP-1a, a member of the grainyhead family of transcription factors. Parekh, V., McEwen, A., Barbour, V., Takahashi, Y., Rehg, J.E., Jane, S.M., Cunningham, J.M. Mol. Cell. Biol. (2004) [Pubmed]
  5. Grainyhead-related transcription factor is required for duct maturation in the salivary gland and the kidney of the mouse. Yamaguchi, Y., Yonemura, S., Takada, S. Development (2006) [Pubmed]
  6. Characterization of the molecularly cloned murine alpha-globin transcription factor CP2. Lim, L.C., Fang, L., Swendeman, S.L., Sheffery, M. J. Biol. Chem. (1993) [Pubmed]
  7. Transcription factor CP2 is crucial in hemoglobin synthesis during erythroid terminal differentiation in vitro. Chae, J.H., Lee, Y.H., Kim, C.G. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  8. Transcription factor CP2 is involved in activating mBMP4 in mouse mesenchymal stem cells. Kang, H.C., Chae, J.H., Kim, B.S., Han, S.Y., Kim, S.H., Auh, C.K., Yang, S.I., Kim, C.G. Mol. Cells (2004) [Pubmed]
  9. Distinct rat proteins can recognize CCAAT-homologous sequences of the metallothionein promoter and trans-activate this promoter. Aniskovitch, L.P., Jacob, S.T. Oncogene (1998) [Pubmed]
  10. Self-administration of intravenous amphetamine is predicted by individual differences in sucrose feeding in rats. DeSousa, N.J., Bush, D.E., Vaccarino, F.J. Psychopharmacology (Berl.) (2000) [Pubmed]
  11. Potential role for phosphatidic acid in mediating the inflammatory responses to TNF alpha and IL-1 beta. Bursten, S., Weeks, R., West, J., Le, T., Wilson, T., Porubek, D., Bianco, J.A., Singer, J.W., Rice, G.C. Circ. Shock (1994) [Pubmed]
  12. Genomic organization, chromosomal mapping and promoter analysis of the mouse selenocysteine tRNA gene transcription-activating factor (mStaf) gene. Adachi, K., Katsuyama, M., Song, S., Oka, T. Biochem. J. (2000) [Pubmed]
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