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Gene Review

WNT2B  -  wingless-type MMTV integration site family...

Homo sapiens

Synonyms: Protein Wnt-13, Protein Wnt-2b, WNT13, XWNT2
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Disease relevance of WNT2B


Psychiatry related information on WNT2B

  • These results suggest that the Wnt-13 gene may be involved in normal human development or differentiation as well as in human carcinogenesis [4].

High impact information on WNT2B

  • To understand the molecular mechanism that controls the prolonged progenitor cell proliferation in the ciliary marginal zone, we employed a candidate molecule approach, focusing on Wnt2b (formerly know as Wnt13), which is expressed in the marginal most tip of the retina [5].
  • Mitochondrial and nuclear forms of Wnt13 are generated via alternative promoters, alternative RNA splicing, and alternative translation start sites [6].
  • Wnt13 nuclear forms increased the beta-catenin/T-cell factor activity in HEK293 cells and increased apoptosis in bovine aortic endothelial cells [6].
  • Altogether our results demonstrate that, in addition to alternative promoters and RNA splicing, an alternative translation start in Wnt13B and Wnt13C mRNAs increases the complexity of both human wnt13 expression and functions [6].
  • The time course of induction, its induction by HMBA, and its persistence in differentiated cells indicate that Wnt-13 expression is not dependent upon direct activation by retinoic acid [2].

Biological context of WNT2B


Anatomical context of WNT2B


Associations of WNT2B with chemical compounds

  • Mammalian WNT2B orthologs acquired the transmembrane domain and integrin-targeting RGD motif during vertebrate evolution [1].
  • Nucleotide sequence analysis indicated that the Wnt-13 gene encodes the protein of 372 amino acids, including a signal peptide, two potential N-glycosylation sites and 24 cystein residues highly conserved among members of the Wnt gene family [4].

Other interactions of WNT2B


Analytical, diagnostic and therapeutic context of WNT2B


  1. WNT2B: comparative integromics and clinical applications (Review). Katoh, M. Int. J. Mol. Med. (2005) [Pubmed]
  2. Human Wnt-13 is developmentally regulated during the differentiation of NTERA-2 pluripotent human embryonal carcinoma cells. Wakeman, J.A., Walsh, J., Andrews, P.W. Oncogene (1998) [Pubmed]
  3. Differential expression of Wnt genes, beta-catenin and E-cadherin in human brain tumors. Howng, S.L., Wu, C.H., Cheng, T.S., Sy, W.D., Lin, P.C., Wang, C., Hong, Y.R. Cancer Lett. (2002) [Pubmed]
  4. Cloning, expression and chromosomal localization of Wnt-13, a novel member of the Wnt gene family. Katoh, M., Hirai, M., Sugimura, T., Terada, M. Oncogene (1996) [Pubmed]
  5. Wnt2b controls retinal cell differentiation at the ciliary marginal zone. Kubo, F., Takeichi, M., Nakagawa, S. Development (2003) [Pubmed]
  6. Mitochondrial and nuclear forms of Wnt13 are generated via alternative promoters, alternative RNA splicing, and alternative translation start sites. Struewing, I.T., Toborek, A., Mao, C.D. J. Biol. Chem. (2006) [Pubmed]
  7. Elucidation of correspondence between swine chromosome 4 and human chromosome 1 by assigning 27 genes to the ImpRH map, and development of microsatellites in the proximity of 14 genes. Hiraiwa, H., Sawazaki, T., Suzuki, K., Fujishima-Kanaya, N., Toki, D., Ito, Y., Uenishi, H., Hayashi, T., Awata, T., Yasue, H. Cytogenet. Genome Res. (2003) [Pubmed]
  8. WNT2 and human gastrointestinal cancer (review). Katoh, M. Int. J. Mol. Med. (2003) [Pubmed]
  9. Molecular cloning and characterization of mouse St7r (St7-like, St7l). Saitoh, T., Katoh, M. Int. J. Mol. Med. (2002) [Pubmed]
  10. WNT2B2 mRNA, up-regulated in primary gastric cancer, is a positive regulator of the WNT- beta-catenin-TCF signaling pathway. Katoh, M., Kirikoshi, H., Terasaki, H., Shiokawa, K. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  11. Analysis of chicken Wnt-13 expression demonstrates coincidence with cell division in the developing eye and is consistent with a role in induction. Jasoni, C., Hendrickson, A., Roelink, H. Dev. Dyn. (1999) [Pubmed]
  12. Activation of Wnt/beta-catenin signaling in distinct histologic subtypes of human germ cell tumors. Fritsch, M.K., Schneider, D.T., Schuster, A.E., Murdoch, F.E., Perlman, E.J. Pediatr. Dev. Pathol. (2006) [Pubmed]
  13. Alternative splicing of the WNT-2B/WNT-13 gene. Katoh, M., Kirikoshi, H., Saitoh, T., Sagara, N., Koike, J. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
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