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Gene Review

VANGL1  -  VANGL planar cell polarity protein 1

Homo sapiens

Synonyms: KITENIN, LPP2, Loop-tail protein 2 homolog, STB2, STBM2, ...
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Disease relevance of VANGL1

  • Transfection of antisense S-oligonucleotides, but not of sense S-oligonucleotides, into hepatoma cells suppressed expression of VANGL1 and subsequent growth of these cells was inhibited to a marked degree [1].
  • Interestingly, two of the phage surface displayed peptides enriched with basic amino acid residues, STB1 (HKKPSKS) and STB2 (TKRNNKR), showed a cross binding affinity to both metal oxides [2].
  • On the other hand, STB2 mRNA was significantly down-regulated in a pancreatic cancer cell line AsPC-1 [3].
  • Assembly site of cyanophage LPP-2-SPL in Plectonema boryanum [4].
  • STB2 is highly expressed in MKN28, MKN74 (gastric cancer), BxPC-3, PSN-1, and Hs766T (pancreatic cancer) cells [5].

High impact information on VANGL1


Biological context of VANGL1

  • This prompted us to ask whether another van gogh/strabismus gene, one more closely related to human VANGL1, exists in the zebrafish genome [7].
  • STB2 gene was clustered with Calsequestrin 2 (CASQ2) gene in tail-to-tail manner (interval less than 5.0 kb), and CASQ2 gene is mapped to human chromosome 1p11-p13.3 or linked to human chromosome 1p13-p21 [3].
  • STB2 gene consisted of at lest 7 exons, and encoded a 524-amino-acid protein with 4 transmembrane domains and the C-terminal Ser/Thr-X-Val motif [3].
  • Here, STB2/VANGL1 gene fragments were identified in human genome draft sequences by using bioinformatics, and STB2 cDNAs were isolated by using cDNA-PCR [3].
  • STB1 and STB2 genes are located around cancer susceptibility loci or recombination hot spots in the human genome [5].

Associations of VANGL1 with chemical compounds

  • In transfected IEC, FLAG-Vangl1 was mostly present in the Nonidet P-40 soluble fraction as detected by Western blotting, corresponding to the localization of endogenous protein in cytoplasmic vesicular structures by confocal microscopy with rabbit polyclonal anti-human Vangl1 antibody (alpha-Vangl1) [6].

Other interactions of VANGL1


Analytical, diagnostic and therapeutic context of VANGL1


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