The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Dysarthria


Psychiatry related information on Dysarthria


High impact information on Dysarthria

  • Dysarthria resulting from lithium carbonate. A case report [11].
  • There is considerable inter- and intrafamilial variability, including dysarthria, axial dystonia and gait disturbances [12].
  • Episodic ataxia type 2 (EA2) is a dominantly inherited disorder, characterized by spells of ataxia, dysarthria, vertigo, and migraines, associated with mutations in the neuronal calcium-channel gene CACNA1A [13].
  • We have evaluated two male patients with CMTX who on separate occasions developed transient ataxia, dysarthria, and weakness within 3 days of returning from ski trips at altitudes above 8,000 feet [14].
  • Immediate withdrawal of cyclosporine at the onset of a change in mental status or dysarthria and improvement in intra- and postoperative management may have contributed to the decreased incidence of neurological complications [15].

Chemical compound and disease context of Dysarthria

  • Chronic dysarthria and metoclopramide [16].
  • A double-blind trial of clonazepam in the treatment of parkinsonian dysarthria [17].
  • In contrast, the aggravation of gait disorder, postural instability, and dysarthria was more severe, with decreased percentage of improvement on levodopa in patients with longer evolution [18].
  • Ten days after accidental exposure to carbon monoxide, a 17-year-old youth developed transitory choreoathetosis of both arms, face, and neck, with moderate dysarthria [19].
  • Three patients were dropped from the study, two for reasons unrelated to treatment and one because of the appearance of vertigo, headache, dysarthria, and ataxia, which subsided rapidly when vigabatrin was stopped (3 g daily) [20].

Biological context of Dysarthria


Anatomical context of Dysarthria


Gene context of Dysarthria

  • In addition, recessive POLG1 mutations are responsible for sensory-atactic neuropathy, dysarthria and ophthalmoplegia (SANDO), juvenile spino-cerebellar ataxia-epilepsy syndrome (SCAE) and Alpers-Huttenlocher hepatopathic poliodystrophy [27].
  • The presence of mutation in the PANK2 gene is associated with younger age at onset and a higher frequency of dystonia, dysarthria, intellectual impairment, and gait disturbance [28].
  • PRIMARY OBJECTIVE: To investigate the nature of the motor speech impairments and dysarthria that can arise subsequent to treatment for childhood mid-line cerebellar tumours (CMCT) [29].
  • Strained, strangled, and tremulous vocal qualities that are typically seen in adductor spasmodic dysphonia (ADSD), voice tremor (Tremor), and the spastic dysarthria of amyotrophic lateral sclerosis (ALS) may sound similar and be difficult to differentiate [30].
  • RESULTS: Two sisters and a brother developed progressive ataxia, dysarthria, mild cognitive impairment, and sensorimotor neuropathy at age 30, combined with epilepsy in one sibling [31].

Analytical, diagnostic and therapeutic context of Dysarthria


  1. A gene for episodic ataxia/myokymia maps to chromosome 12p13. Litt, M., Kramer, P., Browne, D., Gancher, S., Brunt, E.R., Root, D., Phromchotikul, T., Dubay, C.J., Nutt, J. Am. J. Hum. Genet. (1994) [Pubmed]
  2. Lesch-Nyhan syndrome: a study of motor behavior and cerebrospinal fluid neurotransmitters. Jankovic, J., Caskey, T.C., Stout, J.T., Butler, I.J. Ann. Neurol. (1988) [Pubmed]
  3. Intravenous administration of diazepam in patients with chronic liver disease. Branch, R.A., Morgan, M.H., James, J., Read, A.E. Gut (1976) [Pubmed]
  4. Botulinum toxin A in patients with oromandibular dystonia: long-term follow-up. Tan, E.K., Jankovic, J. Neurology (1999) [Pubmed]
  5. Isolated pontine infarctions with prominent ipsilateral midfacial sensory signs. Masjuan, J., Barón, M., Lousa, M., Gobernado, J.M. Stroke (1997) [Pubmed]
  6. Language functions in Huntington's disease. Podoll, K., Caspary, P., Lange, H.W., Noth, J. Brain (1988) [Pubmed]
  7. Persistent dysarthria with apraxia associated with a combination of lithium carbonate and haloperidol. Bond, W.S., Carvalho, M., Foulks, E.F. The Journal of clinical psychiatry. (1982) [Pubmed]
  8. Does cognitive impairment in Parkinson's disease result from non-dopaminergic lesions? Pillon, B., Dubois, B., Cusimano, G., Bonnet, A.M., Lhermitte, F., Agid, Y. J. Neurol. Neurosurg. Psychiatr. (1989) [Pubmed]
  9. Phenytoin/isradipine interaction causing severe neurologic toxicity. Cachat, F., Tufro, A. The Annals of pharmacotherapy. (2002) [Pubmed]
  10. Basal Ganglia calcification in mitochondrial disorders. Finsterer, J., Kopsa, W. Metabolic brain disease. (2005) [Pubmed]
  11. Dysarthria resulting from lithium carbonate. A case report. Solomon, K., Vickers, R. JAMA (1975) [Pubmed]
  12. Mutations in TITF-1 are associated with benign hereditary chorea. Breedveld, G.J., van Dongen, J.W., Danesino, C., Guala, A., Percy, A.K., Dure, L.S., Harper, P., Lazarou, L.P., van der Linde, H., Joosse, M., Grüters, A., MacDonald, M.E., de Vries, B.B., Arts, W.F., Oostra, B.A., Krude, H., Heutink, P. Hum. Mol. Genet. (2002) [Pubmed]
  13. Novel CACNA1A mutation causes febrile episodic ataxia with interictal cerebellar deficits. Subramony, S.H., Schott, K., Raike, R.S., Callahan, J., Langford, L.R., Christova, P.S., Anderson, J.H., Gomez, C.M. Ann. Neurol. (2003) [Pubmed]
  14. Transient central nervous system white matter abnormality in X-linked Charcot-Marie-Tooth disease. Paulson, H.L., Garbern, J.Y., Hoban, T.F., Krajewski, K.M., Lewis, R.A., Fischbeck, K.H., Grossman, R.I., Lenkinski, R., Kamholz, J.A., Shy, M.E. Ann. Neurol. (2002) [Pubmed]
  15. Neurological complications following liver transplantation. Stein, D.P., Lederman, R.J., Vogt, D.P., Carey, W.D., Broughan, T.A. Ann. Neurol. (1992) [Pubmed]
  16. Chronic dysarthria and metoclopramide. Walsh, T.D. Ann. Neurol. (1982) [Pubmed]
  17. A double-blind trial of clonazepam in the treatment of parkinsonian dysarthria. Biary, N., Pimental, P.A., Langenberg, P.W. Neurology (1988) [Pubmed]
  18. Does long-term aggravation of Parkinson's disease result from nondopaminergic lesions? Bonnet, A.M., Loria, Y., Saint-Hilaire, M.H., Lhermitte, F., Agid, Y. Neurology (1987) [Pubmed]
  19. Delayed choreoathetosis following acute carbon monoxide poisoning. Schwartz, A., Hennerici, M., Wegener, O.H. Neurology (1985) [Pubmed]
  20. Vigabatrin in the treatment of epilepsy: a double-blind, placebo-controlled study. Tartara, A., Manni, R., Galimberti, C.A., Hardenberg, J., Orwin, J., Perucca, E. Epilepsia (1986) [Pubmed]
  21. Images in neuroscience. Progressive dysarthria: structural and brain correlations. Selnes, O.A., Holcomb, H.H., Gordon, B. The American journal of psychiatry. (1996) [Pubmed]
  22. Spinocerebellar ataxia type 17: extension of phenotype with putaminal rim hyperintensity on magnetic resonance imaging. Loy, C.T., Sweeney, M.G., Davis, M.B., Wills, A.J., Sawle, G.V., Lees, A.J., Tabrizi, S.J. Mov. Disord. (2005) [Pubmed]
  23. Occupational and environmental toxicology of mercury and its compounds. Satoh, H. Industrial health. (2000) [Pubmed]
  24. Muscle-nerve involvement in autosomal dominant progressive external ophthalmoplegia with hypogonadism. Melberg, A., Lundberg, P.O., Henriksson, K.G., Olsson, Y., Stålberg, E. Muscle Nerve (1996) [Pubmed]
  25. Concomitant stroke and Candida parapsilosis native valve endocarditis: report of one case and literature review. Li, C.S., Huang, C.R., Lu, C.H., Lui, C.C., Chien, C.C., Chang, W.N. Acta neurologica Taiwanica. (2004) [Pubmed]
  26. Bilateral hypoglossal nerve palsy due to vertical subluxation of the odontoid process in rheumatoid arthritis. Macedo, T.F., Gow, P.J., Heap, S.W., Wallis, W.E. Br. J. Rheumatol. (1988) [Pubmed]
  27. Disorders of nuclear-mitochondrial intergenomic signaling. Spinazzola, A., Zeviani, M. Gene (2005) [Pubmed]
  28. Clinical heterogeneity of neurodegeneration with brain iron accumulation (Hallervorden-Spatz syndrome) and pantothenate kinase-associated neurodegeneration. Thomas, M., Hayflick, S.J., Jankovic, J. Mov. Disord. (2004) [Pubmed]
  29. Differential motor speech outcomes in children treated for mid-line cerebellar tumour. Cornwell, P.L., Murdoch, B.E., Ward, E.C. Brain injury : [BI]. (2005) [Pubmed]
  30. Spastic/spasmodic vs. tremulous vocal quality: motor speech profile analysis. Lundy, D.S., Roy, S., Xue, J.W., Casiano, R.R., Jassir, D. Journal of voice : official journal of the Voice Foundation. (2004) [Pubmed]
  31. Adult-onset autosomal recessive ataxia with thalamic lesions in a Finnish family. Rantamäki, M., Krahe, R., Paetau, A., Cormand, B., Mononen, I., Udd, B. Neurology (2001) [Pubmed]
  32. Mid-brain pathology of Wilson's disease: MRI analysis of three cases. Hitoshi, S., Iwata, M., Yoshikawa, K. J. Neurol. Neurosurg. Psychiatr. (1991) [Pubmed]
  33. Automatic speech recognition and training for severely dysarthric users of assistive technology: the STARDUST project. Parker, M., Cunningham, S., Enderby, P., Hawley, M., Green, P. Clinical linguistics & phonetics. (2006) [Pubmed]
  34. Manganese-induced Parkinsonism in a patient undergoing maintenance hemodialysis. Ohtake, T., Negishi, K., Okamoto, K., Oka, M., Maesato, K., Moriya, H., Kobayashi, S. Am. J. Kidney Dis. (2005) [Pubmed]
WikiGenes - Universities