Gene Review:
Zmpste24 - zinc metallopeptidase, STE24
Mus musculus
Synonyms:
A530043O15Rik, CAAX prenyl protease 1 homolog, D030046F19, FACE-1, FACE1, ...
Fong,
Ng,
Lammerding,
Vickers,
Meta,
Coté,
Gavino,
Qiao,
Chang,
Young,
Yang,
Stewart,
Lee,
Bennett,
Bergo,
Young,
Young,
Fong,
Michaelis,
Fong,
Frost,
Meta,
Qiao,
Yang,
Coffinier,
Young,
Jiang,
Zhao,
Liao,
Dai,
Wu,
Genant,
Bergo,
Gavino,
Ross,
Schmidt,
Hong,
Kendall,
Mohr,
Meta,
Genant,
Jiang,
Wisner,
Van Bruggen,
Carano,
Michaelis,
Griffey,
Young,
- Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect. Bergo, M.O., Gavino, B., Ross, J., Schmidt, W.K., Hong, C., Kendall, L.V., Mohr, A., Meta, M., Genant, H., Jiang, Y., Wisner, E.R., Van Bruggen, N., Carano, R.A., Michaelis, S., Griffey, S.M., Young, S.G. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice. Fong, L.G., Ng, J.K., Meta, M., Coté, N., Yang, S.H., Stewart, C.L., Sullivan, T., Burghardt, A., Majumdar, S., Reue, K., Bergo, M.O., Young, S.G. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Hutchinson-Gilford progeria syndrome. Pollex, R.L., Hegele, R.A. Clin. Genet. (2004)
- Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice. Pendás, A.M., Zhou, Z., Cadiñanos, J., Freije, J.M., Wang, J., Hultenby, K., Astudillo, A., Wernerson, A., Rodríguez, F., Tryggvason, K., López-Otín, C. Nat. Genet. (2002)
- Genomic instability in laminopathy-based premature aging. Liu, B., Wang, J., Chan, K.M., Tjia, W.M., Deng, W., Guan, X., Huang, J.D., Li, K.M., Chau, P.Y., Chen, D.J., Pei, D., Pendas, A.M., Cadiñanos, J., López-Otín, C., Tse, H.F., Hutchison, C., Chen, J., Cao, Y., Cheah, K.S., Tryggvason, K., Zhou, Z. Nat. Med. (2005)
- A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria. Fong, L.G., Frost, D., Meta, M., Qiao, X., Yang, S.H., Coffinier, C., Young, S.G. Science (2006)
- Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation. Varela, I., Cadiñanos, J., Pendás, A.M., Gutiérrez-Fernández, A., Folgueras, A.R., Sánchez, L.M., Zhou, Z., Rodríguez, F.J., Stewart, C.L., Vega, J.A., Tryggvason, K., Freije, J.M., López-Otín, C. Nature (2005)
- Prelamin A and lamin A appear to be dispensable in the nuclear lamina. Fong, L.G., Ng, J.K., Lammerding, J., Vickers, T.A., Meta, M., Coté, N., Gavino, B., Qiao, X., Chang, S.Y., Young, S.R., Yang, S.H., Stewart, C.L., Lee, R.T., Bennett, C.F., Bergo, M.O., Young, S.G. J. Clin. Invest. (2006)
- Prelamin A, Zmpste24, misshapen cell nuclei, and progeria--new evidence suggesting that protein farnesylation could be important for disease pathogenesis. Young, S.G., Fong, L.G., Michaelis, S. J. Lipid Res. (2005)
- From immature lamin to premature aging: molecular pathways and therapeutic opportunities. Cadiñanos, J., Varela, I., López-Otín, C., Freije, J.M. Cell Cycle (2005)
- Biochemical studies of Zmpste24-deficient mice. Leung, G.K., Schmidt, W.K., Bergo, M.O., Gavino, B., Wong, D.H., Tam, A., Ashby, M.N., Michaelis, S., Young, S.G. J. Biol. Chem. (2001)
- Application of micro-CT assessment of 3-D bone microstructure in preclinical and clinical studies. Jiang, Y., Zhao, J., Liao, E.Y., Dai, R.C., Wu, X.P., Genant, H.K. J. Bone Miner. Metab. (2005)
- A series of bioactivity-variant neurotoxins from scorpion Buthus martensii Karsch: X-ray crystal structure and functional implications. Wang, D.C. Journal of natural toxins. (1999)