Gene Review:
ITGB2 - integrin, beta 2 (complement component 3...
Homo sapiens
Synonyms:
CD18, Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta, Complement receptor C3 subunit beta, Integrin beta-2, LAD, ...
- Binding of the integrin Mac-1 (CD11b/CD18) to the third immunoglobulin-like domain of ICAM-1 (CD54) and its regulation by glycosylation. Diamond, M.S., Staunton, D.E., Marlin, S.D., Springer, T.A. Cell (1991)
- Low expression of lymphocyte function-associated antigen (LFA)-1 and LFA-3 adhesion molecules is a common trait in Burkitt's lymphoma associated with and not associated with Epstein-Barr virus. Billaud, M., Rousset, F., Calender, A., Cordier, M., Aubry, J.P., Laisse, V., Lenoir, G.M. Blood (1990)
- Involvement of LFA-1/intracellular adhesion molecule-1-dependent cell adhesion in CD40-mediated inhibition of human B lymphoma cell death induced by surface IgM crosslinking. Sumimoto, S., Heike, T., Kanazashi, S., Shintaku, N., Jung, E.Y., Hata, D., Katamura, K., Mayumi, M. J. Immunol. (1994)
- Monocytic expression of CD14 and CD18, circulating adhesion molecules and inflammatory markers in women with diabetes mellitus and impaired glucose tolerance. Fogelstrand, L., Hulthe, J., Hultén, L.M., Wiklund, O., Fagerberg, B. Diabetologia (2004)
- Statin compounds reduce human immunodeficiency virus type 1 replication by preventing the interaction between virion-associated host intercellular adhesion molecule 1 and its natural cell surface ligand LFA-1. Giguère, J.F., Tremblay, M.J. J. Virol. (2004)
- Constitutive and induced phosphorylation of the alpha- and beta-chains of the CD11/CD18 leukocyte integrin family. Relationship to adhesion-dependent functions. Buyon, J.P., Slade, S.G., Reibman, J., Abramson, S.B., Philips, M.R., Weissmann, G., Winchester, R. J. Immunol. (1990)
- Acute psychological stress and exercise and changes in peripheral leukocyte adhesion molecule expression and density. Goebel, M.U., Mills, P.J. Psychosomatic medicine. (2000)
- Microglial cells around amyloid plaques in Alzheimer's disease express leucocyte adhesion molecules of the LFA-1 family. Rozemuller, J.M., Eikelenboom, P., Pals, S.T., Stam, F.C. Neurosci. Lett. (1989)
- Role of lymphocyte adhesion receptors in transient interactions and cell locomotion. Dustin, M.L., Springer, T.A. Annu. Rev. Immunol. (1991)
- The lymphocyte function-associated LFA-1, CD2, and LFA-3 molecules: cell adhesion receptors of the immune system. Springer, T.A., Dustin, M.L., Kishimoto, T.K., Marlin, S.D. Annu. Rev. Immunol. (1987)
- Alpha L beta 2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule. Kolanus, W., Nagel, W., Schiller, B., Zeitlmann, L., Godar, S., Stockinger, H., Seed, B. Cell (1996)
- The binding site on ICAM-1 for Plasmodium falciparum-infected erythrocytes overlaps, but is distinct from, the LFA-1-binding site. Berendt, A.R., McDowall, A., Craig, A.G., Bates, P.A., Sternberg, M.J., Marsh, K., Newbold, C.I., Hogg, N. Cell (1992)
- pH dependence of neutrophil-endothelial cell adhesion and adhesion molecule expression. Serrano, C.V., Fraticelli, A., Paniccia, R., Teti, A., Noble, B., Corda, S., Faraggiana, T., Ziegelstein, R.C., Zweier, J.L., Capogrossi, M.C. Am. J. Physiol. (1996)
- Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy. Hirahashi, J., Mekala, D., Van Ziffle, J., Xiao, L., Saffaripour, S., Wagner, D.D., Shapiro, S.D., Lowell, C., Mayadas, T.N. Immunity (2006)
- Tumor necrosis factor mediates experimental pulmonary edema by ICAM-1 and CD18-dependent mechanisms. Lo, S.K., Everitt, J., Gu, J., Malik, A.B. J. Clin. Invest. (1992)
- IL-4 induces LFA-1 and LFA-3 expression on Burkitt's lymphoma cell lines. Requirement of additional activation by phorbol myristate acetate for induction of homotypic cell adhesions. Rousset, F., Billaud, M., Blanchard, D., Figdor, C., Lenoir, G.M., Spits, H., De Vries, J.E. J. Immunol. (1989)
- Vav1 phosphorylation is induced by beta2 integrin engagement on natural killer cells upstream of actin cytoskeleton and lipid raft reorganization. Riteau, B., Barber, D.F., Long, E.O. J. Exp. Med. (2003)
- Cytohesin-1 regulates beta-2 integrin-mediated adhesion through both ARF-GEF function and interaction with LFA-1. Geiger, C., Nagel, W., Boehm, T., van Kooyk, Y., Figdor, C.G., Kremmer, E., Hogg, N., Zeitlmann, L., Dierks, H., Weber, K.S., Kolanus, W. EMBO J. (2000)
- Induction of tyrosine phosphorylation during ICAM-3 and LFA-1-mediated intercellular adhesion, and its regulation by the CD45 tyrosine phosphatase. Arroyo, A.G., Campanero, M.R., Sánchez-Mateos, P., Zapata, J.M., Ursa, M.A., del Pozo, M.A., Sánchez-Madrid, F. J. Cell Biol. (1994)
- Retinoic acid induces aggregation of the acute promyelocytic leukemia cell line NB-4 by utilization of LFA-1 and ICAM-2. Larson, R.S., Brown, D.C., Sklar, L.A. Blood (1997)
- Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity. Bianchi, E., Denti, S., Granata, A., Bossi, G., Geginat, J., Villa, A., Rogge, L., Pardi, R. Nature (2000)
- A novel leukocyte adhesion deficiency caused by expressed but nonfunctional beta2 integrins Mac-1 and LFA-1. Hogg, N., Stewart, M.P., Scarth, S.L., Newton, R., Shaw, J.M., Law, S.K., Klein, N. J. Clin. Invest. (1999)
- Identification of surface proteins mediating adherence of CD11/CD18-deficient lymphoblastoid cells to cultured human endothelium. Schwartz, B.R., Wayner, E.A., Carlos, T.M., Ochs, H.D., Harlan, J.M. J. Clin. Invest. (1990)
- Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro. Smith, C.W., Marlin, S.D., Rothlein, R., Toman, C., Anderson, D.C. J. Clin. Invest. (1989)
- ICAM-1 (CD54): a counter-receptor for Mac-1 (CD11b/CD18). Diamond, M.S., Staunton, D.E., de Fougerolles, A.R., Stacker, S.A., Garcia-Aguilar, J., Hibbs, M.L., Springer, T.A. J. Cell Biol. (1990)
- Differential induction of VCAM-1 on human iliac venous and arterial endothelial cells and its role in adhesion. Hauser, I.A., Johnson, D.R., Madri, J.A. J. Immunol. (1993)
- Modulation of granulocyte LAM-1 and MAC-1 during dialysis--a prospective, randomized controlled trial. Himmelfarb, J., Zaoui, P., Hakim, R. Kidney Int. (1992)
- Endothelial-leukocyte adhesion molecule-1-dependent and leukocyte (CD11/CD18)-dependent mechanisms contribute to polymorphonuclear leukocyte adhesion to cytokine-activated human vascular endothelium. Luscinskas, F.W., Brock, A.F., Arnaout, M.A., Gimbrone, M.A. J. Immunol. (1989)
- Regulation of adhesion and transendothelial migration of natural killer cells. Allavena, P., Bianchi, G., Paganin, C., Giardina, G., Mantovani, A. Nat. Immun. (1996)
- Cytohesin-1 is a dynamic regulator of distinct LFA-1 functions in leukocyte arrest and transmigration triggered by chemokines. Weber, K.S., Weber, C., Ostermann, G., Dierks, H., Nagel, W., Kolanus, W. Curr. Biol. (2001)
- Exogenous eosinophil activation converts PSGL-1-dependent binding to CD18-dependent stable adhesion to platelets in shear flow. McCarty, O.J., Tien, N., Bochner, B.S., Konstantopoulos, K. Am. J. Physiol., Cell Physiol. (2003)
- P-selectin and MAC-1 mediate monocyte rolling and adhesion to ECM-bound platelets under flow conditions. Kuijper, P.H., Gallardo Torres, H.I., Houben, L.A., Lammers, J.W., Zwaginga, J.J., Koenderman, L. J. Leukoc. Biol. (1998)
- Rapid and prominent up-regulation of high-affinity receptor for immunoglobulin G (Fc gamma RI) by cross-linking of beta 2 integrins on polymorphonuclear leukocytes. Takano, K., Kaganoi, J., Yamamoto, K., Takahashi, A., Kido, T., Sasada, M. Int. J. Hematol. (2000)
- The urokinase receptor (CD87) facilitates CD11b/CD18-mediated adhesion of human monocytes. Sitrin, R.G., Todd, R.F., Albrecht, E., Gyetko, M.R. J. Clin. Invest. (1996)
- Expression of integrins and examination of their adhesive function in normal and leukemic hematopoietic cells. Liesveld, J.L., Winslow, J.M., Frediani, K.E., Ryan, D.H., Abboud, C.N. Blood (1993)
- Neutrophil and monocyte adherence to and migration across monolayers of cytokine-activated endothelial cells: the contribution of CD18, ELAM-1, and VLA-4. Hakkert, B.C., Kuijpers, T.W., Leeuwenberg, J.F., van Mourik, J.A., Roos, D. Blood (1991)
- Phenotype analysis of hematopoietic CD34+ cell populations derived from human umbilical cord blood using flow cytometry and cDNA-polymerase chain reaction. Thoma, S.J., Lamping, C.P., Ziegler, B.L. Blood (1994)
- Evidence for an involvement of the neutrophil integrin lymphocyte function-associated antigen-1 in early failure of heart transplants. Oubenaissa, A., Mouas, C., Bourgeois, F., Le Deist, F., Albérici, G., Moalic, J.M., Menasché, P. Circulation (1996)
- Transfection of vitamin D receptor cDNA into the monoblastoid cell line U937. The role of vitamin D3 in homotypic macrophage adhesion. Hewison, M., Dabrowski, M., Faulkner, L., Hughson, E., Vadher, S., Rut, A., Brickell, P.M., O'Riordan, J.L., Katz, D.R. J. Immunol. (1994)
- Human endothelial-cell specific molecule-1 binds directly to the integrin CD11a/CD18 (LFA-1) and blocks binding to intercellular adhesion molecule-1. Béchard, D., Scherpereel, A., Hammad, H., Gentina, T., Tsicopoulos, A., Aumercier, M., Pestel, J., Dessaint, J.P., Tonnel, A.B., Lassalle, P. J. Immunol. (2001)