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Gene Review

Adcyap1r1  -  adenylate cyclase activating polypeptide 1...

Rattus norvegicus

Synonyms: PAC1-R, PACAP type I receptor, PACAP-R-1, PACAP-R1, PACAP-R1A, ...
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High impact information on Adcyap1r1

  • The increased PACAP responsiveness induced by these growth factors in PC-12 cells may therefore result from the expression of the PACAP-R-hop isoform, positively coupled to both adenylyl cyclase and phospholipase C [1].
  • The present study has shown, for the first time, the exact site of PACAP-R expression in the brain and hypophysis [2].
  • Thus, the expression of PACAP-R was detected not only on neuronal cells but also on some particular glial cells [2].
  • In the brain, expression of PACAP-R mRNA was most prominent in the periglomerular and granule cells of the olfactory bulb, granule cells of the dentate gyrus, supraoptic nucleus, and area postrema [2].
  • The distribution of the mRNA for a pituitary adenylate cyclase-activating polypeptide (PACAP) receptor (PACAP-R) was examined in the rat brain, and also in the hypophysis and pineal gland, by in situ hybridization with a specific 35S-labeled riboprobe which was generated from a rat PACAP-R cDNA clone [2].

Biological context of Adcyap1r1


Anatomical context of Adcyap1r1


Associations of Adcyap1r1 with chemical compounds


Other interactions of Adcyap1r1


Analytical, diagnostic and therapeutic context of Adcyap1r1

  • The phase-shifting effect is channeled to the clock via a PACAP-R1 receptor, because mRNA from this receptor was demonstrated in the ventral SCN by in situ hybridization [8].


  1. Differentiation induces pituitary adenylate cyclase-activating polypeptide receptor expression in PC-12 cells. Cavallaro, S., D'Agata, V., Guardabasso, V., Travali, S., Stivala, F., Canonico, P.L. Mol. Pharmacol. (1995) [Pubmed]
  2. Distribution of the mRNA for a pituitary adenylate cyclase-activating polypeptide receptor in the rat brain: an in situ hybridization study. Hashimoto, H., Nogi, H., Mori, K., Ohishi, H., Shigemoto, R., Yamamoto, K., Matsuda, T., Mizuno, N., Nagata, S., Baba, A. J. Comp. Neurol. (1996) [Pubmed]
  3. Assignments of the genes for rat pituitary adenylate cyclase activating polypeptide (Adcyap1) and its receptor subtypes (Adcyap1r1, Adcyap1r2, and Adcyap1r3). Cai, Y., Xin, X., Yamada, T., Muramatsu, Y., Szpirer, C., Matsumoto, K. Cytogenet. Cell Genet. (1995) [Pubmed]
  4. Effect of pituitary adenylate cyclase-activating polypeptide (PACAP) on progestin biosynthesis in cultured granulosa cells from rat ovary and expression of mRNA encoding PACAP type IA receptor. Kotani, E., Usuki, S., Kubo, T. J. Reprod. Fertil. (1998) [Pubmed]
  5. Tissue-specific and developmental expression of pituitary adenylate cyclase-activating polypeptide (PACAP) receptors in rat brain. D'Agata, V., Cavallaro, S., Stivala, F., Canonico, P.L. Eur. J. Neurosci. (1996) [Pubmed]
  6. Rat corpus luteum expresses both PACAP and PACAP type IA receptor mRNAs. Kotani, E., Usuki, S., Kubo, T. Peptides (1997) [Pubmed]
  7. Pituitary adenylate cyclase-activating polypeptide (PACAP) receptor mRNA in the rat adrenal gland: localization by in situ hybridization and identification of splice variants. Nogi, H., Hashimoto, H., Fujita, T., Hagihara, N., Matsuda, T., Baba, A. Jpn. J. Pharmacol. (1997) [Pubmed]
  8. Pituitary adenylate cyclase-activating peptide (PACAP) in the retinohypothalamic tract: a potential daytime regulator of the biological clock. Hannibal, J., Ding, J.M., Chen, D., Fahrenkrug, J., Larsen, P.J., Gillette, M.U., Mikkelsen, J.D. J. Neurosci. (1997) [Pubmed]
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