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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Area Postrema

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Disease relevance of Area Postrema


Psychiatry related information on Area Postrema


High impact information on Area Postrema


Chemical compound and disease context of Area Postrema


Biological context of Area Postrema


Anatomical context of Area Postrema


Associations of Area Postrema with chemical compounds


Gene context of Area Postrema

  • In situ hybridization histochemistry failed to detect constitutive expression of the chemokine transcript in the cerebral tissue except for the area postrema (AP) that exhibited a low signal under basal conditions [28].
  • The results presented here extend our previous finding of expression of the Celsr1 receptor in the embryo and show that expression continues into adult life when expression in the brain is localized principally in the ependymal cell layer, choroid plexus, and the area postrema [29].
  • The results indicate that DOCA and DEX may increase the sensitivity of the brain to the behavioral and physiological actions of AngII by upregulating AT1 receptors in the SFO and area postrema [30].
  • Systemic ADM gains access to the brain through the area postrema (AP), a brainstem circumventricular organ, and the PVN is a major target of these ADM-sensitive AP neurons [31].
  • The most remarkable finding was the detection of a strong signal for Notch2 mRNA in two circumventricular organs: the subfornical organ and the area postrema [32].

Analytical, diagnostic and therapeutic context of Area Postrema


  1. Involvement of the area postrema in the regulation of sympathetic outflow to the cardiovascular system. Bishop, V.S., Hay, M. Frontiers in neuroendocrinology. (1993) [Pubmed]
  2. Location of the area postrema pressor pathway in the dog brain stem. Barnes, K.L., Ferrario, C.M. Hypertension (1984) [Pubmed]
  3. The localisation of the extraneuronal monoamine transporter (EMT) in rat brain. Haag, C., Berkels, R., Gründemann, D., Lazar, A., Taubert, D., Schömig, E. J. Neurochem. (2004) [Pubmed]
  4. Spatially and temporally differentiated patterns of c-fos expression in brainstem catecholaminergic cell groups induced by cardiovascular challenges in the rat. Chan, R.K., Sawchenko, P.E. J. Comp. Neurol. (1994) [Pubmed]
  5. Hyperthermic induction of the 27-kDa heat shock protein (Hsp27) in neuroglia and neurons of the rat central nervous system. Krueger-Naug, A.M., Hopkins, D.A., Armstrong, J.N., Plumier, J.C., Currie, R.W. J. Comp. Neurol. (2000) [Pubmed]
  6. Conditioned taste aversions and changes in motor activity in lithium-treated rats. Mediating role of the area postrema. Ladowsky, R.L., Ossenkopp, K.P. Neuropharmacology (1986) [Pubmed]
  7. Response of mesencephalic and hypothalamic dopamine neurones to alpha-MSH: mediated by area postrema? Lichtensteiger, W., Lienhart, R. Nature (1977) [Pubmed]
  8. Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells. Xiang, M., Zhou, L., Peng, Y.W., Eddy, R.L., Shows, T.B., Nathans, J. Neuron (1993) [Pubmed]
  9. Role of AT1 receptors in the resetting of the baroreflex control of heart rate by angiotensin II in the rabbit. Wong, J., Chou, L., Reid, I.A. J. Clin. Invest. (1993) [Pubmed]
  10. Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure. Baggio, L.L., Huang, Q., Brown, T.J., Drucker, D.J. Gastroenterology (2004) [Pubmed]
  11. The area postrema in deoxycorticosterone-salt hypertension in rats. Fink, G.D., Pawloski, C.M., Blair, M.L., Mangiapane, M.L. Hypertension (1987) [Pubmed]
  12. Noradrenaline-induced emesis. Alpha-2 adrenoceptor mediation in the area postrema. Beleslin, D.B., Strbac, M. Neuropharmacology (1987) [Pubmed]
  13. Fos expression in neurons projecting to the pressor region in the rostral ventrolateral medulla after sustained hypertension in conscious rabbits. Polson, J.W., Potts, P.D., Li, Y.W., Dampney, R.A. Neuroscience (1995) [Pubmed]
  14. 5-HT3 receptor antagonists injected into the area postrema inhibit cisplatin-induced emesis in the ferret. Higgins, G.A., Kilpatrick, G.J., Bunce, K.T., Jones, B.J., Tyers, M.B. Br. J. Pharmacol. (1989) [Pubmed]
  15. High dorsal column cordotomy plus subdiaphragmatic vagotomy prevents acute ionizing radiation sickness in cats. Borison, H.L., McCarthy, L.E., Johnson, J.R. Exp. Neurol. (1987) [Pubmed]
  16. Atrial natriuretic factor. Genest, J., Cantin, M. Circulation (1987) [Pubmed]
  17. Atrial natriuretic factor receptor subtypes in the rat central nervous system. Konrad, E.M., Thibault, G., Schiffrin, E.L., Cantin, M. Hypertension (1991) [Pubmed]
  18. Role of area postrema in transgene hypertension. Averill, D.B., Matsumura, K., Ganten, D., Ferrario, C.M. Hypertension (1996) [Pubmed]
  19. Role of the area postrema in angiotensin II modulation of baroreflex control of heart rate in conscious mice. Xue, B., Gole, H., Pamidimukkala, J., Hay, M. Am. J. Physiol. Heart Circ. Physiol. (2003) [Pubmed]
  20. A comparison of GABA- and GAD-like immunoreactivity within the area postrema of the rat and cat. Newton, B.W., Maley, B.E. J. Comp. Neurol. (1987) [Pubmed]
  21. Interactions of vasopressin with the area postrema in arterial baroreflex function in conscious rabbits. Undesser, K.P., Hasser, E.M., Haywood, J.R., Johnson, A.K., Bishop, V.S. Circ. Res. (1985) [Pubmed]
  22. Microcirculation of the area postrema. Permeability and vascular responses. Faraci, F.M., Choi, J., Baumbach, G.L., Mayhan, W.G., Heistad, D.D. Circ. Res. (1989) [Pubmed]
  23. Medullary catecholaminergic neurons in the normal human brain and in Parkinson's disease. Saper, C.B., Sorrentino, D.M., German, D.C., de Lacalle, S. Ann. Neurol. (1991) [Pubmed]
  24. Noradrenergic neurons in the zebrafish hindbrain are induced by retinoic acid and require tfap2a for expression of the neurotransmitter phenotype. Holzschuh, J., Barrallo-Gimeno, A., Ettl, A.K., Durr, K., Knapik, E.W., Driever, W. Development (2003) [Pubmed]
  25. Glucokinase is the likely mediator of glucosensing in both glucose-excited and glucose-inhibited central neurons. Dunn-Meynell, A.A., Routh, V.H., Kang, L., Gaspers, L., Levin, B.E. Diabetes (2002) [Pubmed]
  26. Reflex effect of vasopressin after blockade of V1 receptors in the area postrema. Hasser, E.M., Bishop, V.S. Circ. Res. (1990) [Pubmed]
  27. Inhibition of nitric oxide formation in the nucleus tractus solitarius increases renal sympathetic nerve activity in rabbits. Harada, S., Tokunaga, S., Momohara, M., Masaki, H., Tagawa, T., Imaizumi, T., Takeshita, A. Circ. Res. (1993) [Pubmed]
  28. Regulation of the gene encoding the monocyte chemoattractant protein 1 (MCP-1) in the mouse and rat brain in response to circulating LPS and proinflammatory cytokines. Thibeault, I., Laflamme, N., Rivest, S. J. Comp. Neurol. (2001) [Pubmed]
  29. Celsr1, a neural-specific gene encoding an unusual seven-pass transmembrane receptor, maps to mouse chromosome 15 and human chromosome 22qter. Hadjantonakis, A.K., Sheward, W.J., Harmar, A.J., de Galan, L., Hoovers, J.M., Little, P.F. Genomics (1997) [Pubmed]
  30. Mineralocorticoids and glucocorticoids cooperatively increase salt intake and angiotensin II receptor binding in rat brain. Shelat, S.G., King, J.L., Flanagan-Cato, L.M., Fluharty, S.J. Neuroendocrinology (1999) [Pubmed]
  31. Autonomic and neuroendocrine actions of adrenomedullin in the brain: mechanisms for homeostasis. Shan, J., Stachniak, T., Jhamandas, J.H., Krukoff, T.L. Regul. Pept. (2003) [Pubmed]
  32. Differential expression of Notch1 and Notch2 in developing and adult mouse brain. Higuchi, M., Kiyama, H., Hayakawa, T., Hamada, Y., Tsujimoto, Y. Brain Res. Mol. Brain Res. (1995) [Pubmed]
  33. Evidence for an intramedullary prostaglandin-dependent mechanism in the activation of stress-related neuroendocrine circuitry by intravenous interleukin-1. Ericsson, A., Arias, C., Sawchenko, P.E. J. Neurosci. (1997) [Pubmed]
  34. Attenuated cardiovascular response to adenosine in the brain stem nuclei of spontaneously hypertensive rats. Tseng, C.J., Ger, L.P., Lin, H.C., Tung, C.S. Hypertension (1995) [Pubmed]
  35. A Na(+)/Cl(-)-dependent transporter for catecholamines, identified as a norepinephrine transporter, is expressed in the brain of the teleost fish medaka (Oryzias latipes). Roubert, C., Sagné, C., Kapsimali, M., Vernier, P., Bourrat, F., Giros, B. Mol. Pharmacol. (2001) [Pubmed]
  36. Inhibition of phosphoprotein phosphatases blocks metabotropic glutamate receptor effects in the rat nucleus tractus solitarii. Glaum, S.R., Miller, R.J. Mol. Pharmacol. (1994) [Pubmed]
  37. Immunohistochemical localization and biochemical characterization of nerve growth factor receptor in adult rat brain. Yan, Q., Johnson, E.M. J. Comp. Neurol. (1989) [Pubmed]
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