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Gene Review

ADCYAP1R1  -  adenylate cyclase activating polypeptide 1...

Homo sapiens

Synonyms: PAC1, PAC1R, PACAP type I receptor, PACAP-R-1, PACAP-R1, ...
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Disease relevance of ADCYAP1R1


High impact information on ADCYAP1R1

  • Studies of the genes encoding the PACAP precursor and the type I PACAP receptor provide information on the control of PACAP gene expression and on the relationship between the structure of the receptor subtypes and the activation of various signal transduction pathways [5].
  • We report here the cloning, characterization, and chromosomal location of the gene encoding the human type I VIP receptor (HVR1), also termed the type II PACAP receptor [6].
  • We previously described alternative splicing of the region encoding the third intracellular loop of the PACAP receptor generating six isoforms with differential signal transduction properties (Spengler, D., Waeber, C., Pantaloni, C., Holsboer, F., Bockaert, J., Seeburg, P. H., and Journot, L. (1993) Nature 365, 170-175) [7].
  • The PACAP receptor was solubilized from bovine brain membranes with digitonin and purified 30-fold by the combination of DEAE-Toyopearl and hydroxylapatite chromatographic analyses [8].
  • However, none of the VIP/PACAP receptor proteins has been visualized individually in human tumors [9].

Biological context of ADCYAP1R1


Anatomical context of ADCYAP1R1


Associations of ADCYAP1R1 with chemical compounds


Regulatory relationships of ADCYAP1R1

  • VIP/PACAP receptor activation stimulates the production of [cAMP]i and [Ca2+]i by coupling to independent G-protein subunits, although agonist potencies for the different transduction pathways appear to differ [18].

Other interactions of ADCYAP1R1


Analytical, diagnostic and therapeutic context of ADCYAP1R1


  1. G-protein-coupled receptor kinase 3- and protein kinase C-mediated desensitization of the PACAP receptor type 1 in human Y-79 retinoblastoma cells. Dautzenberg, F.M., Hauger, R.L. Neuropharmacology (2001) [Pubmed]
  2. PACAP(6-38) is a PACAP receptor antagonist for breast cancer cells. Leyton, J., Gozes, Y., Pisegna, J., Coy, D., Purdom, S., Casibang, M., Zia, F., Moody, T.W. Breast Cancer Res. Treat. (1999) [Pubmed]
  3. Expression of pituitary adenylate cyclase activating polypeptide and receptors in human brain tumors. Vertongen, P., d'Haens, J., Michotte, A., Velkeniers, B., van Rampelbergh, J., Svoboda, M., Robberecht, P. Peptides (1995) [Pubmed]
  4. Antagonistic properties are shifted back to agonistic properties by further N-terminal shortening of pituitary adenylate-cyclase-activating peptides in human neuroblastoma NB-OK-1 cell membranes. Vandermeers, A., Vandenborre, S., Hou, X., de Neef, P., Robberecht, P., Vandermeers-Piret, M.C., Christophe, J. Eur. J. Biochem. (1992) [Pubmed]
  5. Pituitary adenylate cyclase activating polypeptide (PACAP) and its receptors: neuroendocrine and endocrine interaction. Arimura, A., Shioda, S. Frontiers in neuroendocrinology. (1995) [Pubmed]
  6. Structure, expression, and chromosomal localization of the type I human vasoactive intestinal peptide receptor gene. Sreedharan, S.P., Huang, J.X., Cheung, M.C., Goetzl, E.J. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  7. Alternative splicing in the N-terminal extracellular domain of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor modulates receptor selectivity and relative potencies of PACAP-27 and PACAP-38 in phospholipase C activation. Pantaloni, C., Brabet, P., Bilanges, B., Dumuis, A., Houssami, S., Spengler, D., Bockaert, J., Journot, L. J. Biol. Chem. (1996) [Pubmed]
  8. Purification and characterization of the receptor for pituitary adenylate cyclase-activating polypeptide. Ohtaki, T., Masuda, Y., Ishibashi, Y., Kitada, C., Arimura, A., Fujino, M. J. Biol. Chem. (1993) [Pubmed]
  9. Immunocytochemical identification of VPAC1, VPAC2, and PAC1 receptors in normal and neoplastic human tissues with subtype-specific antibodies. Schulz, S., Röcken, C., Mawrin, C., Weise, W., Höllt, V., Schulz, S. Clin. Cancer Res. (2004) [Pubmed]
  10. Human type I pituitary adenylate cyclase activating polypeptide receptor (ADCYAP1R): localization to chromosome band 7p14 and integration into the cytogenetic, physical, and genetic map of chromosome 7. Stoffel, M., Espinosa, R., Trabb, J.B., Le Beau, M.M., Bell, G.I. Genomics (1994) [Pubmed]
  11. A cloned frog vasoactive intestinal polypeptide/pituitary adenylate cyclase-activating polypeptide receptor exhibits pharmacological and tissue distribution characteristics of both VPAC1 and VPAC2 receptors in mammals. Alexandre, D., Anouar, Y., Jegou, S., Fournier, A., Vaudry, H. Endocrinology (1999) [Pubmed]
  12. Stage-specific expression of pituitary adenylate cyclase-activating polypeptide type I receptor messenger ribonucleic acid during ovarian follicle development in the rat. Park, H.J., Lee, J., Wang, L., Park, J.H., Kwon, H.B., Arimura, A., Chun, S.Y. Endocrinology (2000) [Pubmed]
  13. Localization and characterization of pituitary adenylate cyclase-activating polypeptide receptors in the human cerebellum during development. Basille, M., Cartier, D., Vaudry, D., Lihrmann, I., Fournier, A., Freger, P., Gallo-Payet, N., Vaudry, H., Gonzalez, B. J. Comp. Neurol. (2006) [Pubmed]
  14. Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor. Ogi, K., Miyamoto, Y., Masuda, Y., Habata, Y., Hosoya, M., Ohtaki, T., Masuo, Y., Onda, H., Fujino, M. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  15. Tissue specific expression of different human receptor types for pituitary adenylate cyclase activating polypeptide and vasoactive intestinal polypeptide: implications for their role in human physiology. Wei, Y., Mojsov, S. J. Neuroendocrinol. (1996) [Pubmed]
  16. Pituitary adenylate cyclase activating peptide and its receptors are expressed in human neuroblastomas. Vertongen, P., Devalck, C., Sariban, E., De Laet, M.H., Martelli, H., Paraf, F., Hélardot, P., Robberecht, P. J. Cell. Physiol. (1996) [Pubmed]
  17. Excitatory and inhibitory actions of pituitary adenylate cyclase-activating peptide (PACAP) in the internal anal sphincter smooth muscle: sites of actions. Rattan, S., Chakder, S. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
  18. VIP and PACAP receptor pharmacology: a comparison of intracellular signaling pathways. Dickson, L., Aramori, I., Sharkey, J., Finlayson, K. Ann. N. Y. Acad. Sci. (2006) [Pubmed]
  19. Pituitary adenylate cyclase-activating polypeptide (PACAP) and PACAP-receptor type 1 expression in rat and human placenta. Scaldaferri, M.L., Modesti, A., Palumbo, C., Ulisse, S., Fabbri, A., Piccione, E., Frajese, G., Moretti, C. Endocrinology (2000) [Pubmed]
  20. Pituitary adenylate cyclase-activating polypeptide directly modulates the activity of proopiomelanocortin neurons in the rat arcuate nucleus. Mounien, L., Bizet, P., Boutelet, I., Gourcerol, G., Fournier, A., Vaudry, H., J??gou, S. Neuroscience (2006) [Pubmed]
  21. Vasoactive intestinal peptide modification at position 22 allows discrimination between receptor subtypes. Gourlet, P., Vandermeers-Piret, M.C., Rathé, J., De Neef, P., Cnudde, J., Robberecht, P., Waelbroeck, M. Eur. J. Pharmacol. (1998) [Pubmed]
  22. Induction of type I PACAP receptor expression by the new zinc finger protein Zac1 and p53. Hoffmann, A., Ciani, E., Houssami, S., Brabet, P., Journot, L., Spengler, D. Ann. N. Y. Acad. Sci. (1998) [Pubmed]
  23. Vasoactive intestinal polypeptide- and pituitary adenylate cyclase activating polypeptide-mediated control of catecholamine release from chromaffin tissue in the rainbow trout, Oncorhynchus mykiss. Montpetit, C.J., Perry, S.F. J. Endocrinol. (2000) [Pubmed]
  24. PACAP stimulates the release of interleukin-6 in cultured rat Müller cells. Seki, T., Hinohara, Y., Taki, C., Nakatani, M., Ozawa, M., Nishimura, S., Takaki, A., Itho, H., Takenoya, F., Shioda, S. Ann. N. Y. Acad. Sci. (2006) [Pubmed]
  25. Specific antibody recognition of rat pituitary adenylate cyclase activating polypeptide receptors. Li, M., Shioda, S., Somogyvári-Vigh, A., Onda, H., Arimura, A. Endocrine (1997) [Pubmed]
  26. Effect of pituitary adenylate cyclase-activating polypeptide (PACAP) on IL-6, IL-8, and MCP-1 expression in human retinal pigment epithelial cell line. Zhang, X.Y., Hayasaka, S., Chi, Z.L., Cui, H.S., Hayasaka, Y. Curr. Eye Res. (2005) [Pubmed]
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