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Gene Review

Spink3  -  serine peptidase inhibitor, Kazal type 3

Rattus norvegicus

Synonyms: Cholecystokinin-releasing peptide, Monitor peptide, PSTI-I, Pancreatic secretory trypsin inhibitor, Psti-1, ...
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Disease relevance of Spink1

  • We propose that PSTI-I prevents pancreatitis by inhibiting the activity of trypsin, rather than by reducing trypsinogen activation [1].
  • Increased secretion of the pancreatic secretory trypsin inhibitor (PSTI-I, monitor peptide) during development of chronic pancreatitis in the WBN/Kob rat [2].

High impact information on Spink1


Biological context of Spink1


Anatomical context of Spink1

  • In the small intestine, PSTI-I, also called 'monitor peptide', is thought to have a different role: PSTI-I competes with protein for activated trypsin [10].

Other interactions of Spink1


Analytical, diagnostic and therapeutic context of Spink1


  1. Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice. Nathan, J.D., Romac, J., Peng, R.Y., Peyton, M., Macdonald, R.J., Liddle, R.A. Gastroenterology (2005) [Pubmed]
  2. Increased secretion of the pancreatic secretory trypsin inhibitor (PSTI-I, monitor peptide) during development of chronic pancreatitis in the WBN/Kob rat. Graf, R., Schiesser, M., Bimmler, D. Pancreatology (2002) [Pubmed]
  3. Diazepam-binding inhibitor mediates feedback regulation of pancreatic secretion and postprandial release of cholecystokinin. Li, Y., Hao, Y., Owyang, C. J. Clin. Invest. (2000) [Pubmed]
  4. Diazepam binding inhibitor is a potent cholecystokinin-releasing peptide in the intestine. Herzig, K.H., Schön, I., Tatemoto, K., Ohe, Y., Li, Y., Fölsch, U.R., Owyang, C. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  5. Purification and sequencing of a trypsin-sensitive cholecystokinin-releasing peptide from rat pancreatic juice. Its homology with pancreatic secretory trypsin inhibitor. Iwai, K., Fukuoka, S., Fushiki, T., Tsujikawa, M., Hirose, M., Tsunasawa, S., Sakiyama, F. J. Biol. Chem. (1987) [Pubmed]
  6. Complementary nucleotide sequence for monitor peptide, a novel cholecystokinin-releasing peptide in the rat. Fukuoka, S.I., Scheele, G. Nucleic Acids Res. (1989) [Pubmed]
  7. Regulation of the action of the novel cholecystokinin-releasing peptide diazepam binding inhibitor by inhibitory hormones and taurocholate. Herzig, K.H., Wilgus, C., Schön, I., Tatemoto, K., Fölsch, U.R. Regul. Pept. (1998) [Pubmed]
  8. On the cDNA's for two types of rat pancreatic secretory trypsin inhibitor. Horii, A., Tomita, N., Yokouchi, H., Doi, S., Uda, K., Ogawa, M., Mori, T., Matsubara, K. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
  9. Effect of a high-protein diet on the gene expression of a trypsin-sensitive, cholecystokinin-releasing peptide (monitor peptide) in the pancreas. Tsuzuki, S., Fushiki, T., Kondo, A., Murayama, H., Sugimoto, E. Eur. J. Biochem. (1991) [Pubmed]
  10. The bifunctional rat pancreatic secretory trypsin inhibitor/monitor peptide provides protection against premature activation of pancreatic juice. Graf, R., Klauser, S., Fukuoka, S.I., Schiesser, M., Bimmler, D. Pancreatology (2003) [Pubmed]
  11. Growth stimulating activity on 3T3 fibroblasts of the molecular weight 6,500-peptide purified from rat pancreatic juice. Fukuoka, S., Fushiki, T., Kitagawa, Y., Sugimoto, E., Iwai, K. Biochem. Biophys. Res. Commun. (1986) [Pubmed]
  12. Rapid and selective cloning of monitor peptide, a novel cholecystokinin-releasing peptide, using minimal amino acid sequence and the polymerase chain reaction. Fukuoka, S., Scheele, G.A. Pancreas (1990) [Pubmed]
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