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Yes1  -  Yamaguchi sarcoma viral (v-yes) oncogene...

Rattus norvegicus

Synonyms: Tyrosine-protein kinase Yes, Yes, c-Yes, p60c-yes, p61-Yes
 
 
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High impact information on Yes1

 

Biological context of Yes1

 

Anatomical context of Yes1

  • Coimmunoprecipitation demonstrated that Yes forms a complex with the focal adhesion protein Pyk2, which increased with CCK stimulation [7].
  • Identification of autophosphorylation sites in c-Yes purified from rat liver plasma membranes [4].
  • Answer, Yes, apparently there is, since hemivasectomy contralateral to the excised testis partially suppressed the testicular hemicastration response (150.4 +/- 13.2 ng/ml in hemicastrated, sham- hemivasectomized rats [n = 18] vs. 109.4 +/- 11.6 ng/ml in hemicastrated, hemivasectomized rats [n = 18], P less than 0.026) [8].
 

Associations of Yes1 with chemical compounds

  • The findings suggest that vimentin might serve as molecular support for Yes kinase and, since previous studies have shown that vimentin in amoeboid microglia is one of the major protein substrates of serine/threonine protein kinases, this function could be regulated by phosphorylation [5].
  • Moreover, two Src family kinases (Fyn and Yes) were activated by angiotensin II in a time- and concentration-dependent manner [9].
 

Other interactions of Yes1

  • We conclude that Yes participates in the regulation of the acinar cell actin, probably by interaction with Pyk2 [7].
  • Upon stimulation with supramaximal secretory CCK (10(-8) M), Yes became reversibly tyrosine-phosphorylated and activated within 2 min [7].
  • However, Fyn and c-Yes tend to concentrate at the egg cortex, though only Fyn is localized to the spindle as well [10].
 

Analytical, diagnostic and therapeutic context of Yes1

  • The autophosphorylated c-Yes was extensively digested by trypsin and the resultant two major phosphopeptides, peptides I and II, were purified by HPLC on a reversed-phase C-18 column [4].
  • c-Yes was purified 322-fold from a rat liver plasma membrane fraction to a single 60-kDa band on SDS-PAGE [4].
  • Microinjection of antibodies against Fyn and Yes blocked angiotensin II-induced DNA synthesis and c-Fos expression in WB cells, indicating an obligatory involvement of these tyrosine kinases in the activation of the ERK cascade by angiotensin II [9].

References

  1. Involvement of the Src family kinase yes in bile salt-induced apoptosis. Reinehr, R., Becker, S., Wettstein, M., Häussinger, D. Gastroenterology (2004) [Pubmed]
  2. The Src family kinase Yes triggers hyperosmotic activation of the epidermal growth factor receptor and CD95. Reinehr, R., Becker, S., Höngen, A., Haüssinger, D. J. Biol. Chem. (2004) [Pubmed]
  3. Regulation of calcium-sensitive tyrosine kinase Pyk2 by angiotensin II in endothelial cells. Roles of Yes tyrosine kinase and tyrosine phosphatase SHP-2. Tang, H., Zhao, Z.J., Landon, E.J., Inagami, T. J. Biol. Chem. (2000) [Pubmed]
  4. Identification of autophosphorylation sites in c-Yes purified from rat liver plasma membranes. Ariki, M., Tanabe, O., Usui, H., Hayashi, H., Inoue, R., Nishito, Y., Kagamiyama, H., Takeda, M. J. Biochem. (1997) [Pubmed]
  5. Immunocytochemical localization of protein kinases Yes and Src in amoeboid microglia in culture: association of Yes kinase with vimentin intermediate filaments. Ciesielski-Treska, J., Ulrich, G., Chasserot-Golaz, S., Aunis, D. Eur. J. Cell Biol. (1995) [Pubmed]
  6. Does colchicine really induce bone formation in the rodent bone Marrow? Yes, it does. Caselli, G., Fiorentino, S., Riminucci, M., Corsi, A., Bianco, P. Calcif. Tissue Int. (1999) [Pubmed]
  7. The tyrosine kinase Yes regulates actin structure and secretion during pancreatic acinar cell damage in rats. Lynch, G., Kohler, S., Leser, J., Beil, M., Garcia-Marin, L.J., Lutz, M.P. Pflugers Arch. (2004) [Pubmed]
  8. Hypophysectomy and hemivasectomy can inhibit the testicular hemicastration response of the mature rat. Frankel, A.I., Mock, E.J., Chapman, J.C. Biol. Reprod. (1984) [Pubmed]
  9. Angiotensin II induces diverse signal transduction pathways via both Gq and Gi proteins in liver epithelial cells. Tsygankova, O.M., Peng, M., Maloney, J.A., Hopkins, N., Williamson, J.R. J. Cell. Biochem. (1998) [Pubmed]
  10. Are Src family kinases involved in cell cycle resumption in rat eggs? Talmor-Cohen, A., Tomashov-Matar, R., Eliyahu, E., Shapiro, R., Shalgi, R. Reproduction (2004) [Pubmed]
 
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