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Gene Review

Ptk2b  -  protein tyrosine kinase 2 beta

Rattus norvegicus

Synonyms: CADTK, CAK-beta, CAKB, CAKbeta, Calcium-dependent tyrosine kinase, ...
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Disease relevance of Ptk2b


Psychiatry related information on Ptk2b


High impact information on Ptk2b


Chemical compound and disease context of Ptk2b


Biological context of Ptk2b


Anatomical context of Ptk2b


Associations of Ptk2b with chemical compounds


Physical interactions of Ptk2b


Enzymatic interactions of Ptk2b

  • Pyk2 can be dephosphorylated in vitro in SHP-2 immunoprecipitates and in intact cells expressing an NH(2) terminus-truncated form of SHP-2, which lacks the two SH2 domains but has an enhanced phosphatase activity [22].

Regulatory relationships of Ptk2b

  • Inhibition of Pyk2 activation also suppressed Rac1 activation and reactive oxygen species (ROS) production [1].
  • Ang II caused activation of protein kinase C delta (PKCdelta) in C9 cells, and its stimulatory actions on Pyk2 and extracellularly regulated kinase (ERK) phosphorylation were abolished by PKC depletion and selective inhibition of PKCdelta by rottlerin, but not by Ca(2+)-chelators [23].
  • The c-src inhibitor PP1 inhibited carbachol-stimulated phosphorylation of Pyk2 [24].
  • Following ischemia, tyrosine phosphorylation of NR2A and NR2B and activated Src-family kinases (SFKs) and Pyk2 were increased in post-synaptic densities (PSDs) [25].
  • Thus, activating CAKbeta/Pyk2 is required for inducing LTP and may depend upon downstream activation of Src to upregulate NMDA receptors [9].

Other interactions of Ptk2b


Analytical, diagnostic and therapeutic context of Ptk2b


  1. Ca(2+)-sensitive tyrosine kinase Pyk2/CAK beta-dependent signaling is essential for G-protein-coupled receptor agonist-induced hypertrophy. Hirotani, S., Higuchi, Y., Nishida, K., Nakayama, H., Yamaguchi, O., Hikoso, S., Takeda, T., Kashiwase, K., Watanabe, T., Asahi, M., Taniike, M., Tsujimoto, I., Matsumura, Y., Sasaki, T., Hori, M., Otsu, K. J. Mol. Cell. Cardiol. (2004) [Pubmed]
  2. Increased expression of cell adhesion kinase beta in human and rat crescentic glomerulonephritis. Takagi, C., Ueki, K., Ikeuchi, H., Kuroiwa, T., Kaneko, Y., Tsukada, Y., Maezawa, A., Mitaka, T., Sasaki, T., Nojima, Y. Am. J. Kidney Dis. (2002) [Pubmed]
  3. Effects of nonselective cation channels and PI3K on endothelin-1-induced PYK2 tyrosine phosphorylation in C6 glioma cells. Kawanabe, Y., Hashimoto, N., Masaki, T. Am. J. Physiol., Cell Physiol. (2003) [Pubmed]
  4. Differential stimulation of proline-rich tyrosine kinase 2 and mitogen-activated protein kinase by sphingosine 1-phosphate. Guo, C., Zheng, C., Martin-Padura, I., Bian, Z.C., Guan, J.L. Eur. J. Biochem. (1998) [Pubmed]
  5. Electroconvulsive shock increases the phosphorylation of Pyk2 in the rat hippocampus. Jeon, S.H., Oh, S.W., Kang, U.G., Ahn, Y.M., Bae, C.D., Park, J.B., Kim, Y.S. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  6. Lateral hypothalamic signaling mechanisms underlying feeding stimulation: differential contributions of Src family tyrosine kinases to feeding triggered either by NMDA injection or by food deprivation. Khan, A.M., Cheung, H.H., Gillard, E.R., Palarca, J.A., Welsbie, D.S., Gurd, J.W., Stanley, B.G. J. Neurosci. (2004) [Pubmed]
  7. Antidepressant effect of the calcium-activated tyrosine kinase Pyk2 in the lateral septum. Sheehan, T.P., Neve, R.L., Duman, R.S., Russell, D.S. Biol. Psychiatry (2003) [Pubmed]
  8. Pyk2 activation is integral to acid stimulation of sodium/hydrogen exchanger 3. Li, S., Sato, S., Yang, X., Preisig, P.A., Alpern, R.J. J. Clin. Invest. (2004) [Pubmed]
  9. CAKbeta/Pyk2 kinase is a signaling link for induction of long-term potentiation in CA1 hippocampus. Huang, Y., Lu, W., Ali, D.W., Pelkey, K.A., Pitcher, G.M., Lu, Y.M., Aoto, H., Roder, J.C., Sasaki, T., Salter, M.W., MacDonald, J.F. Neuron (2001) [Pubmed]
  10. Tumor necrosis factor-alpha mediates pancreatitis responses in acinar cells via protein kinase C and proline-rich tyrosine kinase 2. Satoh, A., Gukovskaya, A.S., Edderkaoui, M., Daghighian, M.S., Reeve, J.R., Shimosegawa, T., Pandol, S.J. Gastroenterology (2005) [Pubmed]
  11. Calcium-dependent activation of Pyk2 by hypoxia. Beitner-Johnson, D., Ferguson, T., Rust, R.T., Kobayashi, S., Millhorn, D.E. Cell. Signal. (2002) [Pubmed]
  12. N-methyl-D-aspartate receptor and L-type voltage-gated Ca2+ channel activation mediate proline-rich tyrosine kinase 2 phosphorylation during cerebral ischemia in rats. Guo, J., Meng, F., Fu, X., Song, B., Yan, X., Zhang, G. Neurosci. Lett. (2004) [Pubmed]
  13. Lithium suppressed Tyr-402 phosphorylation of proline-rich tyrosine kinase (Pyk2) and interactions of Pyk2 and PSD-95 with NR2A in rat hippocampus following cerebral ischemia. Ma, J., Zhang, G.Y., Liu, Y., Yan, J.Z., Hao, Z.B. Neurosci. Res. (2004) [Pubmed]
  14. Pyk2- and Src-dependent tyrosine phosphorylation of PDK1 regulates focal adhesions. Taniyama, Y., Weber, D.S., Rocic, P., Hilenski, L., Akers, M.L., Park, J., Hemmings, B.A., Alexander, R.W., Griendling, K.K. Mol. Cell. Biol. (2003) [Pubmed]
  15. Nuclear translocation of cell adhesion kinase beta/proline-rich tyrosine kinase 2. Aoto, H., Sasaki, H., Ishino, M., Sasaki, T. Cell Struct. Funct. (2002) [Pubmed]
  16. Paxillin is tyrosine-phosphorylated by and preferentially associates with the calcium-dependent tyrosine kinase in rat liver epithelial cells. Li, X., Earp, H.S. J. Biol. Chem. (1997) [Pubmed]
  17. Activation of cell adhesion kinase beta by mechanical stretch in vascular smooth muscle cells. Iwasaki, H., Yoshimoto, T., Sugiyama, T., Hirata, Y. Endocrinology (2003) [Pubmed]
  18. The role of the Ca2+-sensitive tyrosine kinase Pyk2 and Src in thrombin signalling in rat astrocytes. Wang, H., Reiser, G. J. Neurochem. (2003) [Pubmed]
  19. Potassium channel blocker activates extracellular signal-regulated kinases through Pyk2 and epidermal growth factor receptor in rat cardiomyocytes. Tahara, S., Fukuda, K., Kodama, H., Kato, T., Miyoshi, S., Ogawa, S. J. Am. Coll. Cardiol. (2001) [Pubmed]
  20. Cholecystokinin activates PYK2/CAKbeta by a phospholipase C-dependent mechanism and its association with the mitogen-activated protein kinase signaling pathway in pancreatic acinar cells. Tapia, J.A., Ferris, H.A., Jensen, R.T., García, L.J. J. Biol. Chem. (1999) [Pubmed]
  21. Endothelin-1 stimulates hydrolysis of phosphatidylcholine by phospholipases C and D in intact rat mesenteric arteries. Liu, G.L., Shaw, L., Heagerty, A.M., Ohanian, V., Ohanian, J. J. Vasc. Res. (1999) [Pubmed]
  22. Regulation of calcium-sensitive tyrosine kinase Pyk2 by angiotensin II in endothelial cells. Roles of Yes tyrosine kinase and tyrosine phosphatase SHP-2. Tang, H., Zhao, Z.J., Landon, E.J., Inagami, T. J. Biol. Chem. (2000) [Pubmed]
  23. Calcium-independent activation of extracellularly regulated kinases 1 and 2 by angiotensin II in hepatic C9 cells: roles of protein kinase Cdelta, Src/proline-rich tyrosine kinase 2, and epidermal growth receptor trans-activation. Shah, B.H., Catt, K.J. Mol. Pharmacol. (2002) [Pubmed]
  24. Roles of protein kinase C, Ca2+, Pyk2, and c-Src in agonist activation of rat lacrimal gland p42/p44 MAPK. Hodges, R.R., Rios, J.D., Vrouvlianis, J., Ota, I., Zoukhri, D., Dartt, D.A. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  25. Inhibition of protein kinase C reduces ischemia-induced tyrosine phosphorylation of the N-methyl-d-aspartate receptor. Cheung, H.H., Teves, L., Wallace, M.C., Gurd, J.W. J. Neurochem. (2003) [Pubmed]
  26. Role of EGF Receptor and Pyk2 in endothelin-1-induced ERK activation in rat cardiomyocytes. Kodama, H., Fukuda, K., Takahashi, T., Sano, M., Kato, T., Tahara, S., Hakuno, D., Sato, T., Manabe, T., Konishi, F., Ogawa, S. J. Mol. Cell. Cardiol. (2002) [Pubmed]
  27. FAK+ and PYK2/CAKbeta, two related tyrosine kinases highly expressed in the central nervous system: similarities and differences in the expression pattern. Menegon, A., Burgaya, F., Baudot, P., Dunlap, D.D., Girault, J.A., Valtorta, F. Eur. J. Neurosci. (1999) [Pubmed]
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