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Gene Review

Pdgfra  -  platelet derived growth factor receptor,...

Rattus norvegicus

Synonyms: APDGFR, Alpha platelet-derived growth factor receptor, Alpha-type platelet-derived growth factor receptor, CD140 antigen-like family member A, PDGF-R-alpha, ...
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Disease relevance of Pdgfra


High impact information on Pdgfra

  • Treating asbestos-exposed RLF with PDGF-AA, which binds only PDGF-R alpha, blocked the PDGF binding sites that were upregulated by fiber exposure [2].
  • [125I]PDGF-BB receptor assays showed that normal RLF possess mainly PDGF-R beta and a paucity of PDGF-R alpha [2].
  • High-dose cyclosporin A (CsA) treatment significantly reduced both PDGF-AA and PDGF-R alpha expression in intimal cells [3].
  • Platelet-derived growth factor-AA (PDGF-AA) and its matching alpha receptor (PDGF-R alpha) are upregulated in rat lung fibroblasts (RLFs) after exposure to chrysotile asbestos fibers in vitro, which results in asbestos-induced RLF proliferation [4].
  • EGF-R, PDGF-R alpha, FGF-R3 and Flk-1 are among the PTKs that are activated, and they may mediate perinatal development of renal epithelial, interstitial, or vascular structures [5].

Biological context of Pdgfra


Anatomical context of Pdgfra


Associations of Pdgfra with chemical compounds

  • Thus we investigated whether the PDGF-R alpha is induced in vivo during pulmonary fibrogenesis using a vanadium pentoxide (V2O5) model of lung injury [1].

Other interactions of Pdgfra


Analytical, diagnostic and therapeutic context of Pdgfra


  1. Induction of PDGF receptor-alpha in rat myofibroblasts during pulmonary fibrogenesis in vivo. Bonner, J.C., Lindroos, P.M., Rice, A.B., Moomaw, C.R., Morgan, D.L. Am. J. Physiol. (1998) [Pubmed]
  2. Chrysotile asbestos upregulates gene expression and production of alpha-receptors for platelet-derived growth factor (PDGF-AA) on rat lung fibroblasts. Bonner, J.C., Goodell, A.L., Coin, P.G., Brody, A.R. J. Clin. Invest. (1993) [Pubmed]
  3. Expression and localization of platelet-derived growth factor ligand and receptor protein during acute and chronic rejection of rat cardiac allografts. Lemström, K.B., Koskinen, P.K. Circulation (1997) [Pubmed]
  4. Upregulation of the PDGF-alpha receptor precedes asbestos-induced lung fibrosis in rats. Lasky, J.A., Tonthat, B., Liu, J.Y., Friedman, M., Brody, A.R. Am. J. Respir. Crit. Care Med. (1998) [Pubmed]
  5. Receptor protein tyrosine kinases in perinatal developing rat kidney. Kee, N., McTavish, A.J., Papillon, J., Cybulsky, A.V. Kidney Int. (1997) [Pubmed]
  6. Effects of hypertension and aging on platelet-derived growth factor and platelet-derived growth factor receptor expression in rat aorta and heart. Sarzani, R., Arnaldi, G., Takasaki, I., Brecher, P., Chobanian, A.V. Hypertension (1991) [Pubmed]
  7. Alveolar macrophages stimulated with titanium dioxide, chrysotile asbestos, and residual oil fly ash upregulate the PDGF receptor-alpha on lung fibroblasts through an IL-1beta-dependent mechanism. Lindroos, P.M., Coin, P.G., Badgett, A., Morgan, D.L., Bonner, J.C. Am. J. Respir. Cell Mol. Biol. (1997) [Pubmed]
  8. Platelet-derived growth factor ligand and receptor subunit mRNA in the Sertoli and Leydig cells of the rat testis. Loveland, K.L., Zlatic, K., Stein-Oakley, A., Risbridger, G., deKretser, D.M. Mol. Cell. Endocrinol. (1995) [Pubmed]
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