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Gene Review

Il1rn  -  interleukin 1 receptor antagonist

Rattus norvegicus

Synonyms: IL-1RN, IL-1ra, IL1 inhibitor, IRAP, Il-1ra, ...
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Disease relevance of Il1rn


Psychiatry related information on Il1rn


High impact information on Il1rn


Chemical compound and disease context of Il1rn


Biological context of Il1rn


Anatomical context of Il1rn


Associations of Il1rn with chemical compounds


Physical interactions of Il1rn


Regulatory relationships of Il1rn

  • IL-1 beta-induced current reduction could not be abolished by the interleukin-1 receptor antagonist, indicating that the electrophysiological effects of IL-1 beta are independent of interleukin-1 receptor I (IL-1RI) activation [24].
  • IL-1ra attenuated the sepsis-induced decrease in plasma IGF-I and completely prevented the changes in IGF-I observed in liver, kidney, and the gastrocnemius [25].
  • Moreover, when IL-1 receptor activity was inhibited using an adenoviral vector that expresses the IL-1 receptor antagonist (IL-1ra) in the hippocampus, both short-term and long-term memory retention scores were facilitated [26].
  • Excitotoxic damage due to striatal infusion of an NMDA-receptor agonist (cis-2,4-methanoglutamate) was also markedly inhibited (71%) by injection of the IL-1ra [27].

Other interactions of Il1rn


Analytical, diagnostic and therapeutic context of Il1rn


  1. Glomerular expression of interleukin-1 receptor antagonist and interleukin-1 beta genes in antibody-mediated glomerulonephritis. Tam, F.W., Smith, J., Cashman, S.J., Wang, Y., Thompson, E.M., Rees, A.J. Am. J. Pathol. (1994) [Pubmed]
  2. Substance P and capsaicin-induced mechanical hyperalgesia in the rat knee joint; the involvement of bradykinin B1 and B2 receptors. Davis, A.J., Perkins, M.N. Br. J. Pharmacol. (1996) [Pubmed]
  3. Gene treatment of cerebral stroke by rAAV vector delivering IL-1ra in a rat model. Tsai, T.H., Chen, S.L., Xiao, X., Chiang, Y.H., Lin, S.Z., Kuo, S.W., Liu, D.W., Tsao, Y.P. Neuroreport (2003) [Pubmed]
  4. The role of brain cytokines in mediating the behavioral and neuroendocrine effects of intracerebral mycoplasma fermentans. Yirmiya, R., Weidenfeld, J., Barak, O., Avitsur, R., Pollak, Y., Gallily, R., Wohlman, A., Ovadia, H., Ben-Hur, T. Brain Res. (1999) [Pubmed]
  5. Involvement of brain cytokines in the neurobehavioral disturbances induced by HIV-1 glycoprotein120. Barak, O., Goshen, I., Ben-Hur, T., Weidenfeld, J., Taylor, A.N., Yirmiya, R. Brain Res. (2002) [Pubmed]
  6. Interleukin-1 receptor antagonist ameliorates experimental anti-glomerular basement membrane antibody-associated glomerulonephritis. Tang, W.W., Feng, L., Vannice, J.L., Wilson, C.B. J. Clin. Invest. (1994) [Pubmed]
  7. The mechanism of altered neural function in a rat model of acute colitis. Jacobson, K., McHugh, K., Collins, S.M. Gastroenterology (1997) [Pubmed]
  8. IL-1 is a potent inducer of eosinophil accumulation in rat skin. Inhibition of response by a platelet-activating factor antagonist and an anti-human IL-8 antibody. Sanz, M.J., Weg, V.B., Bolanowski, M.A., Nourshargh, S. J. Immunol. (1995) [Pubmed]
  9. Differential roles of tumor necrosis factor-alpha and interleukin-1 beta in lipopolysaccharide-induced brain injury in the neonatal rat. Cai, Z., Pang, Y., Lin, S., Rhodes, P.G. Brain Res. (2003) [Pubmed]
  10. Hypothalamic dopamine release and local cerebral blood flow during onset of heatstroke in rats. Kao, T.Y., Chio, C.C., Lin, M.T. Stroke (1994) [Pubmed]
  11. Influence of the course of brain inflammation on the endogenous IL-1beta/IL-1Ra balance in the model of brain delayed-type hypersensitivity response to bacillus Calmette-Guérin in Lewis rats. Palin, K., Verrier, D., Tridon, V., Hurst, J., Perry, V.H., Dantzer, R., Lestage, J. J. Neuroimmunol. (2004) [Pubmed]
  12. Anorexia in a rat model of colitis: interaction of interleukin-1 and hypothalamic serotonin. El-Haj, T., Poole, S., Farthing, M.J., Ballinger, A.B. Brain Res. (2002) [Pubmed]
  13. Evaluation of interleukin-1 receptor antagonist (IL-1RA) and tumor necrosis factor binding protein (TNF-BP) in a rodent abscess model of host resistance. Colagiovanni, D.B., Shopp, G.M. Immunopharmacology and immunotoxicology. (1996) [Pubmed]
  14. Interleukin-1 beta (IL-1 beta) modulates prostaglandin production and the natural IL-1 receptor antagonist inhibits ovulation in the optimally stimulated rat ovarian perfusion model. Peterson, C.M., Hales, H.A., Hatasaka, H.H., Mitchell, M.D., Rittenhouse, L., Jones, K.P. Endocrinology (1993) [Pubmed]
  15. Interleukin-1 alpha and interleukin-1 beta stimulate adrenocorticotropin secretion in the rat through a similar hypothalamic receptor(s): effects of interleukin-1 receptor antagonist protein. Matta, S.G., Linner, K.M., Sharp, B.M. Neuroendocrinology (1993) [Pubmed]
  16. Intravenous interleukin-1-beta-induced inhibition of gastric emptying: involvement of central corticotrophin-releasing factor and prostaglandin pathways in rats. Sütö, G., Király, A., Plourde, V., Taché, Y. Digestion (1996) [Pubmed]
  17. Immobilization stress increases mRNA levels of interleukin-1 receptor antagonist in various rat brain regions. Suzuki, E., Shintani, F., Kanba, S., Asai, M., Nakaki, T. Cell. Mol. Neurobiol. (1997) [Pubmed]
  18. Vagal paraganglia bind biotinylated interleukin-1 receptor antagonist: a possible mechanism for immune-to-brain communication. Goehler, L.E., Relton, J.K., Dripps, D., Kiechle, R., Tartaglia, N., Maier, S.F., Watkins, L.R. Brain Res. Bull. (1997) [Pubmed]
  19. Effect of a kinin B2 receptor antagonist on LPS- and cytokine-induced neutrophil migration in rats. Santos, D.R., Calixto, J.B., Souza, G.E. Br. J. Pharmacol. (2003) [Pubmed]
  20. Interleukin-1beta exacerbates and interleukin-1 receptor antagonist attenuates neuronal injury and microglial activation after excitotoxic damage in organotypic hippocampal slice cultures. Hailer, N.P., Vogt, C., Korf, H.W., Dehghani, F. Eur. J. Neurosci. (2005) [Pubmed]
  21. Inhibition of kainic acid induced expression of interleukin-1 beta and interleukin-1 receptor antagonist mRNA in the rat brain by NMDA receptor antagonists. Eriksson, C., Zou, L.P., Ahlenius, S., Winblad, B., Schultzberg, M. Brain Res. Mol. Brain Res. (2000) [Pubmed]
  22. Interleukin 1 beta markedly stimulates nitric oxide formation in the absence of other cytokines or lipopolysaccharide in primary cultured rat hepatocytes but not in Kupffer cells. Kitade, H., Sakitani, K., Inoue, K., Masu, Y., Kawada, N., Hiramatsu, Y., Kamiyama, Y., Okumura, T., Ito, S. Hepatology (1996) [Pubmed]
  23. The inhibitor cytokine interleukin-1 receptor antagonist synergistically augments cyclosporine immunosuppression in a rat cardiac allograft model. Shiraishi, M., Csete, M., Yasunaga, C., McDiarmid, S.V., Vannice, J.L., Busuttil, R.W., Shaked, A. J. Surg. Res. (1995) [Pubmed]
  24. Interleukin-1 beta protects neurons via the interleukin-1 (IL-1) receptor-mediated Akt pathway and by IL-1 receptor-independent decrease of transmembrane currents in vivo. Diem, R., Hobom, M., Grötsch, P., Kramer, B., Bähr, M. Mol. Cell. Neurosci. (2003) [Pubmed]
  25. IL-1 receptor antagonist attenuates sepsis-induced alterations in the IGF system and protein synthesis. Lang, C.H., Fan, J., Cooney, R., Vary, T.C. Am. J. Physiol. (1996) [Pubmed]
  26. Learning modulation by endogenous hippocampal IL-1: blockade of endogenous IL-1 facilitates memory formation. Depino, A.M., Alonso, M., Ferrari, C., del Rey, A., Anthony, D., Besedovsky, H., Medina, J.H., Pitossi, F. Hippocampus. (2004) [Pubmed]
  27. Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat. Relton, J.K., Rothwell, N.J. Brain Res. Bull. (1992) [Pubmed]
  28. Interleukin-1 beta stimulation of 45Ca2+ release from rat striatal slices. Plami, M., Frosini, M., Sgaragli, G. Br. J. Pharmacol. (1996) [Pubmed]
  29. Cytokine mRNA expression during experimental corneal allograft rejection. Torres, P.F., De Vos, A.F., van der Gaag, R., Martins, B., Kijlstra, A. Exp. Eye Res. (1996) [Pubmed]
  30. Interleukin-1 beta (IL-1 beta) induces transforming growth factor-beta, (TGF-beta 1) production by rat aortic smooth muscle cells. Yue, T.L., Wang, X.K., Olson, B., Feuerstein, G. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  31. Modulation of Leydig cell testosterone production by secretory products of macrophages. Afane, M., Dubost, J.J., Sauvezie, B., Issoual, D., Dosgilbert, A., Grizard, G., Boucher, D. Andrologia (1998) [Pubmed]
  32. Amyloid-beta peptide induced inflammatory reaction is mediated by the cytokines tumor necrosis factor and interleukin-1. Sutton, E.T., Thomas, T., Bryant, M.W., Landon, C.S., Newton, C.A., Rhodin, J.A. J. Submicrosc. Cytol. Pathol. (1999) [Pubmed]
  33. The intratracheal administration of endotoxin and cytokines. III. The interleukin-1 (IL-1) receptor antagonist inhibits endotoxin- and IL-1-induced acute inflammation. Ulich, T.R., Yin, S.M., Guo, K.Z., del Castillo, J., Eisenberg, S.P., Thompson, R.C. Am. J. Pathol. (1991) [Pubmed]
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