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Gene Review

CD24  -  CD24 molecule

Homo sapiens

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Disease relevance of CD24


High impact information on CD24

  • Twenty-six patients in whom aggressive B-cell lymphoproliferative syndrome developed after bone marrow (n = 14) or organ (n = 12) transplantation received 0.2 mg of CD21-specific and of CD24-specific antibodies per kilogram of body weight for 10 consecutive days in an open, prospective, multicenter trial [4].
  • All patients had transient neutropenia, apparently because the CD24 molecule is also expressed on granulocytes [4].
  • Human cancer cell lines showed growth inhibition in response to the antibodies, according to their expression levels of CD24 and in dose- and time-dependent manners [5].
  • CD24 is a new oncogene, early at the multistep process of colorectal cancer carcinogenesis [5].
  • CONCLUSIONS: CD24 is overexpressed in the colonic mucosa, already at an early stage of carcinogenesis [5].

Chemical compound and disease context of CD24


Biological context of CD24


Anatomical context of CD24

  • Immunoglobulin mu or gamma heavy chains and the B cell antigens CD23 and CD24 are detected on 50% of an isolated FDC population [14].
  • Moreover, our data suggest that the CD24v/v patients expressed higher levels of CD24 on peripheral blood T cells than did the CD24a/a patients [1].
  • Latex beads coated with purified CD24 from the two carcinoma cell lines but also neutrophils could bind specifically to P-selectin-IgG [2].
  • We report that CD24, a mucin-type glycosylphosphatidylinositol-linked cell surface molecule on human neutrophils, pre B lymphocytes, and many tumors can promote binding to P-selectin [2].
  • The CD24/P-selectin binding pathway could be important in the dissimination of tumor cells by facilitating the interaction with platelets or endothelial cells [2].

Associations of CD24 with chemical compounds

  • CD24, a mucin-type glycoprotein, is a ligand for P-selectin on human tumor cells [2].
  • SC68376, a specific inhibitor of p38 MAPK, inhibited apoptosis induction by CD24 cross-linking, whereas anisomycin, an activator of p38 MAPK, enhanced the apoptosis [13].
  • We previously described the intracellular and cell-surface expression of the CD24 sialic acid-dependent epitope(s) on phytohemagglutinin-activated peripheral blood mononuclear cells [15].
  • Immunohistochemical staining of formalin-fixed, paraffin-embedded tumor specimens from which primary OSPC cultures were derived further confirmed differential expression of CD24 and TROP-1/Ep-CAM markers on OSPC vs. NOVA [16].
  • HSA and CD24 from all cell lines express almost no neutral N-glycans with two or more fucose in contrast to brain HSA and glycoproteins from mouse and human brain [17].

Regulatory relationships of CD24


Other interactions of CD24

  • By using affinity purified CDw40 protein we have also demonstrated that it is antigenically distinct from other B cell-associated Ag, including the six differentiation clusters CD19 to CD24 [18].
  • These include cDNAs encoding the NE markers secretogranin (SCG2), CD24, and ENO2 [19].
  • Strong surface reactivity is seen with CD38 antibodies and with one CD24 antibody (HB8) [20].
  • Lack of CD24 was associated with breaks in 2p25, 5q, and 6q21; CD9 was associated with a break at 6q15 [12].
  • Cloning and expression of CD24 gene in human hepatocellular carcinoma: a potential early tumor marker gene correlates with p53 mutation and tumor differentiation [11].

Analytical, diagnostic and therapeutic context of CD24


  1. CD24 is a genetic modifier for risk and progression of multiple sclerosis. Zhou, Q., Rammohan, K., Lin, S., Robinson, N., Li, O., Liu, X., Bai, X.F., Yin, L., Scarberry, B., Du, P., You, M., Guan, K., Zheng, P., Liu, Y. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. CD24, a mucin-type glycoprotein, is a ligand for P-selectin on human tumor cells. Aigner, S., Sthoeger, Z.M., Fogel, M., Weber, E., Zarn, J., Ruppert, M., Zeller, Y., Vestweber, D., Stahel, R., Sammar, M., Altevogt, P. Blood (1997) [Pubmed]
  3. CD24, a signal-transducing molecule expressed on human B cells, is a major surface antigen on small cell lung carcinomas. Jackson, D., Waibel, R., Weber, E., Bell, J., Stahel, R.A. Cancer Res. (1992) [Pubmed]
  4. Anti-B-cell monoclonal antibodies in the treatment of severe B-cell lymphoproliferative syndrome following bone marrow and organ transplantation. Fischer, A., Blanche, S., Le Bidois, J., Bordigoni, P., Garnier, J.L., Niaudet, P., Morinet, F., Le Deist, F., Fischer, A.M., Griscelli, C. N. Engl. J. Med. (1991) [Pubmed]
  5. CD24 is a new oncogene, early at the multistep process of colorectal cancer carcinogenesis. Sagiv, E., Memeo, L., Karin, A., Kazanov, D., Jacob-Hirsch, J., Mansukhani, M., Rechavi, G., Hibshoosh, H., Arber, N. Gastroenterology (2006) [Pubmed]
  6. CD24 expression is specific for tamoxifen-resistant ductal breast cancer cases. Surowiak, P., Materna, V., Paluchowski, P., Matkowski, R., Wojnar, A., Maciejczyk, A., Pudelko, M., Kornafel, J., Dietel, M., Kristiansen, G., Lage, H., Zabel, M. Anticancer Res. (2006) [Pubmed]
  7. Selection of retrovirally transduced hematopoietic cells using CD24 as a marker of gene transfer. Pawliuk, R., Kay, R., Lansdorp, P., Humphries, R.K. Blood (1994) [Pubmed]
  8. Isolation and characterization of multipotent progenitor cells from the Bowman's capsule of adult human kidneys. Sagrinati, C., Netti, G.S., Mazzinghi, B., Lazzeri, E., Liotta, F., Frosali, F., Ronconi, E., Meini, C., Gacci, M., Squecco, R., Carini, M., Gesualdo, L., Francini, F., Maggi, E., Annunziato, F., Lasagni, L., Serio, M., Romagnani, S., Romagnani, P. J. Am. Soc. Nephrol. (2006) [Pubmed]
  9. CD24 expression in ductal carcinoma in situ and invasive ductal carcinoma of breast: an immunohistochemistry-based pilot study. Bircan, S., Kapucuoglu, N., Baspinar, S., Inan, G., Candir, O. Pathol. Res. Pract. (2006) [Pubmed]
  10. Prognostic value of immunohistochemical estimation of CD24 and Ki67 expression in cisplatin and paclitaxel treated ovarian carcinoma patients. Surowiak, P., Materna, V., Kłak, K., Spaczyński, M., Dietel, M., Kristiansen, G., Lage, H., Zabel, M. Polish journal of pathology : official journal of the Polish Society of Pathologists. (2005) [Pubmed]
  11. Cloning and expression of CD24 gene in human hepatocellular carcinoma: a potential early tumor marker gene correlates with p53 mutation and tumor differentiation. Huang, L.R., Hsu, H.C. Cancer Res. (1995) [Pubmed]
  12. Correlations between immunological phenotype and karyotype in malignant lymphoma. Levine, E.G., Arthur, D.C., Gajl-Peczalska, K.J., LeBien, T.W., Peterson, B.A., Hurd, D.D., Bloomfield, C.D. Cancer Res. (1986) [Pubmed]
  13. Pre-B cell antigen receptor-mediated signal inhibits CD24-induced apoptosis in human pre-B cells. Taguchi, T., Kiyokawa, N., Mimori, K., Suzuki, T., Sekino, T., Nakajima, H., Saito, M., Katagiri, Y.U., Matsuo, N., Matsuo, Y., Karasuyama, H., Fujimoto, J. J. Immunol. (2003) [Pubmed]
  14. Antigenic phenotyping of human follicular dendritic cells isolated from nonmalignant and malignant lymphatic tissue. Petrasch, S., Perez-Alvarez, C., Schmitz, J., Kosco, M., Brittinger, G. Eur. J. Immunol. (1990) [Pubmed]
  15. Antibodies recognizing CD24 LAP epitope on human T cells enhance CD28 and IL-2 T cell proliferation. Salamone, M.C., Rosselot, C., Salamone, G.V., Barboza, M., Kado, M., Fainboim, L. J. Leukoc. Biol. (2001) [Pubmed]
  16. Gene expression profiles in primary ovarian serous papillary tumors and normal ovarian epithelium: identification of candidate molecular markers for ovarian cancer diagnosis and therapy. Santin, A.D., Zhan, F., Bellone, S., Palmieri, M., Cane, S., Bignotti, E., Anfossi, S., Gokden, M., Dunn, D., Roman, J.J., O'Brien, T.J., Tian, E., Cannon, M.J., Shaughnessy, J., Pecorelli, S. Int. J. Cancer (2004) [Pubmed]
  17. N-glycosylation patterns of HSA/CD24 from different cell lines and brain homogenates: a comparison. Ohl, C., Albach, C., Altevogt, P., Schmitz, B. Biochimie (2003) [Pubmed]
  18. The human B lymphocyte and carcinoma antigen, CDw40, is a phosphoprotein involved in growth signal transduction. Paulie, S., Rosén, A., Ehlin-Henriksson, B., Braesch-Andersen, S., Jakobson, E., Koho, H., Perlmann, P. J. Immunol. (1989) [Pubmed]
  19. Molecular characterization of prostatic small-cell neuroendocrine carcinoma. Clegg, N., Ferguson, C., True, L.D., Arnold, H., Moorman, A., Quinn, J.E., Vessella, R.L., Nelson, P.S. Prostate (2003) [Pubmed]
  20. An analysis of myeloma plasma cell phenotype using antibodies defined at the IIIrd International Workshop on Human Leucocyte Differentiation Antigens. Jackson, N., Ling, N.R., Ball, J., Bromidge, E., Nathan, P.D., Franklin, I.M. Clin. Exp. Immunol. (1988) [Pubmed]
  21. CD24 is expressed in ovarian cancer and is a new independent prognostic marker of patient survival. Kristiansen, G., Denkert, C., Schlüns, K., Dahl, E., Pilarsky, C., Hauptmann, S. Am. J. Pathol. (2002) [Pubmed]
  22. Immunophenotyping of non-Hodgkin's lymphoma. Correlation with relapse-free survival. Schuurman, H.J., Huppes, W., Verdonck, L.F., Van Baarlen, J., Van Unnik, J.A. Am. J. Pathol. (1988) [Pubmed]
  23. CD24, a signal transducer modulating B cell activation responses, is a very short peptide with a glycosyl phosphatidylinositol membrane anchor. Kay, R., Rosten, P.M., Humphries, R.K. J. Immunol. (1991) [Pubmed]
  24. Mapping of CD24 and homologous sequences to multiple chromosomal loci. Hough, M.R., Rosten, P.M., Sexton, T.L., Kay, R., Humphries, R.K. Genomics (1994) [Pubmed]
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