The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Pspn  -  persephin

Rattus norvegicus

Synonyms: PSP, Persephin
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Pspn


High impact information on Pspn

  • The GDNF family ligands (GFLs: GDNF, neurturin, persephin, and artemin) signal through RET and a gly-cosyl-phosphatidylinositol (GPI)-anchored coreceptor (GFRalpha1-alpha4) that binds ligand with high affinity and provides specificity [2].
  • In the present study we have examined: (1) the mechanism of action and the function of PSP on nigrostriatal dopamine neurons and (2) the therapeutic potential of PSP, delivered by neural stem cells (NSCs) in a model of Parkinson's disease [1].
  • Interestingly we found that the prenatal ventral mesencephalon and the newborn striatum express high levels of PSP mRNA [1].
  • Thus, our findings are consistent with a direct action of PSP on developing and adult midbrain dopamine neurons and suggest that the delivery of PSP by NSCs may constitute a very useful strategy in the treatment of Parkinson's disease [1].
  • Persephin (PSP) is a neurotrophic factor of the GDNF family that has been found to promote the survival of multiple populations of neurons [1].

Biological context of Pspn

  • NTN, ART, and PSP are also expressed in the developing kidney, and NTN and PSP induce ureteric branching in vitro, but their true in vivo role in kidney morphogenesis is still unclear [3].
  • Spinal motor neurons in the adult showed relatively less ability to transport NRTN than to transport GDNF, although NRTN prevented the cell death of neonatal motor neurons in a manner very similar to GDNF (Yan et al., 1995) and persephin (PSPN) (Milbrandt et al., 1998) [4].

Anatomical context of Pspn


Associations of Pspn with chemical compounds


Other interactions of Pspn


Analytical, diagnostic and therapeutic context of Pspn

  • We have used an RT-PCR approach to start addressing the putative functional significance of PSP by determining sites of its synthesis in the neonatal rat brain [6].
  • The detectability of NTN, PSP, and ART is shown in the rat by Western blot and immunohistochemistry up to 70 h postmortem [11].


  1. Persephin-overexpressing neural stem cells regulate the function of nigral dopaminergic neurons and prevent their degeneration in a model of Parkinson's disease. Akerud, P., Holm, P.C., Castelo-Branco, G., Sousa, K., Rodriguez, F.J., Arenas, E. Mol. Cell. Neurosci. (2002) [Pubmed]
  2. GFRalpha-mediated localization of RET to lipid rafts is required for effective downstream signaling, differentiation, and neuronal survival. Tansey, M.G., Baloh, R.H., Milbrandt, J., Johnson, E.M. Neuron (2000) [Pubmed]
  3. Other neurotrophic factors: glial cell line-derived neurotrophic factor (GDNF). Saarma, M., Sariola, H. Microsc. Res. Tech. (1999) [Pubmed]
  4. Analysis of the retrograde transport of glial cell line-derived neurotrophic factor (GDNF), neurturin, and persephin suggests that in vivo signaling for the GDNF family is GFRalpha coreceptor-specific. Leitner, M.L., Molliver, D.C., Osborne, P.A., Vejsada, R., Golden, J.P., Lampe, P.A., Kato, A.C., Milbrandt, J., Johnson, E.M. J. Neurosci. (1999) [Pubmed]
  5. TGFbeta trophic factors differentially modulate motor axon outgrowth and protection from excitotoxicity. Ho, T.W., Bristol, L.A., Coccia, C., Li, Y., Milbrandt, J., Johnson, E., Jin, L., Bar-Peled, O., Griffin, J.W., Rothstein, J.D. Exp. Neurol. (2000) [Pubmed]
  6. GDNF-related factor persephin is widely distributed throughout the nervous system. Jaszai, J., Farkas, L., Galter, D., Reuss, B., Strelau, J., Unsicker, K., Krieglstein, K. J. Neurosci. Res. (1998) [Pubmed]
  7. Neurturin and GDNF promote proliferation and survival of enteric neuron and glial progenitors in vitro. Heuckeroth, R.O., Lampe, P.A., Johnson, E.M., Milbrandt, J. Dev. Biol. (1998) [Pubmed]
  8. Neuroprotective utility and neurotrophic action of neurturin in postnatal motor neurons: comparison with GDNF and persephin. Bilak, M.M., Shifrin, D.A., Corse, A.M., Bilak, S.R., Kuncl, R.W. Mol. Cell. Neurosci. (1999) [Pubmed]
  9. The GDNF family members neurturin, artemin and persephin promote the morphological differentiation of cultured ventral mesencephalic dopaminergic neurons. Zihlmann, K.B., Ducray, A.D., Schaller, B., Huber, A.W., Krebs, S.H., Andres, R.H., Seiler, R.W., Meyer, M., Widmer, H.R. Brain Res. Bull. (2005) [Pubmed]
  10. Effect of neurturin on multipotent cells isolated from the adult skeletal muscle. Vourc'h, P., Lacar, B., Mignon, L., Lucas, P.A., Young, H.E., Chesselet, M.F. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  11. Neurturin, persephin, and artemin in the human pre- and full-term newborn and adult hippocampus and fascia dentata. Quartu, M., Serra, M.P., Manca, A., Mascia, F., Follesa, P., Del Fiacco, M. Brain Res. (2005) [Pubmed]
WikiGenes - Universities