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Gene Review

Nrtn  -  neurturin

Rattus norvegicus

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Disease relevance of Nrtn


Psychiatry related information on Nrtn


High impact information on Nrtn


Chemical compound and disease context of Nrtn


Biological context of Nrtn


Anatomical context of Nrtn


Associations of Nrtn with chemical compounds

  • Intrastriatal grafting of neurturin-secreting cells protected striatal projection neurons, but not interneurons, from quinolinate excitotoxicity [1].
  • Eight weeks after the 6-OHDA lesion, dopamine concentration significantly increased in the striatum of neurturin-treated animals with improvement of methamphetamine-induced rotation behavior [2].
  • Heparin coinfusion during convection-enhanced delivery (CED) increases the distribution of the glial-derived neurotrophic factor (GDNF) ligand family in rat striatum and enhances the pharmacological activity of neurturin [13].
  • NGF but not GDNF or neurturin enhance acetylcholine tissue levels in striatal organotypic brain slices [14].
  • Changes of mRNA levels of GDNF and its recently discovered congeners persephin, neurturin, artemin in the striatum of lesioned side following 6-hydroxydopamine (6-OHDA) lesion in rodents were investigated with semi-quantitative RT-PCR [15].

Other interactions of Nrtn


Analytical, diagnostic and therapeutic context of Nrtn


  1. Neurturin protects striatal projection neurons but not interneurons in a rat model of Huntington's disease. Pérez-Navarro, E., Akerud, P., Marco, S., Canals, J.M., Tolosa, E., Arenas, E., Alberch, J. Neuroscience (2000) [Pubmed]
  2. Dopaminergic neuroprotection and regeneration by neurturin assessed by using behavioral, biochemical and histochemical measurements in a model of progressive Parkinson's disease. Oiwa, Y., Yoshimura, R., Nakai, K., Itakura, T. Brain Res. (2002) [Pubmed]
  3. Expression of neurturin, glial cell line-derived neurotrophic factor, and their receptor components in light-induced retinal degeneration. Jomary, C., Darrow, R.M., Wong, P., Organisciak, D.T., Jones, S.E. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  4. Neurturin shares receptors and signal transduction pathways with glial cell line-derived neurotrophic factor in sympathetic neurons. Creedon, D.J., Tansey, M.G., Baloh, R.H., Osborne, P.A., Lampe, P.A., Fahrner, T.J., Heuckeroth, R.O., Milbrandt, J., Johnson, E.M. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  5. Expression of GDNF family receptor components during development: implications in the mechanisms of interaction. Yu, T., Scully, S., Yu, Y., Fox, G.M., Jing, S., Zhou, R. J. Neurosci. (1998) [Pubmed]
  6. Neurturin signalling via GFRalpha2 is essential for innervation of glandular but not muscle targets of sacral parasympathetic ganglion neurons. Wanigasekara, Y., Airaksinen, M.S., Heuckeroth, R.O., Milbrandt, J., Keast, J.R. Mol. Cell. Neurosci. (2004) [Pubmed]
  7. Striatopallidal neurons are selectively protected by neurturin in an excitotoxic model of Huntington's disease. Marco, S., Pérez-Navarro, E., Tolosa, E., Arenas, E., Alberch, J. J. Neurobiol. (2002) [Pubmed]
  8. Differential effects of glial cell line-derived neurotrophic factor and neurturin in RET/GFRalpha1-expressing cells. Lee, R.H., Wong, W.L., Chan, C.H., Chan, S.Y. J. Neurosci. Res. (2006) [Pubmed]
  9. Effect of neurturin on multipotent cells isolated from the adult skeletal muscle. Vourc'h, P., Lacar, B., Mignon, L., Lucas, P.A., Young, H.E., Chesselet, M.F. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  10. Neuroprotective utility and neurotrophic action of neurturin in postnatal motor neurons: comparison with GDNF and persephin. Bilak, M.M., Shifrin, D.A., Corse, A.M., Bilak, S.R., Kuncl, R.W. Mol. Cell. Neurosci. (1999) [Pubmed]
  11. Neurturin and GDNF promote proliferation and survival of enteric neuron and glial progenitors in vitro. Heuckeroth, R.O., Lampe, P.A., Johnson, E.M., Milbrandt, J. Dev. Biol. (1998) [Pubmed]
  12. Potential role of glial cell line-derived neurotrophic factor receptors in Müller glial cells during light-induced retinal degeneration. Harada, C., Harada, T., Quah, H.M., Maekawa, F., Yoshida, K., Ohno, S., Wada, K., Parada, L.F., Tanaka, K. Neuroscience (2003) [Pubmed]
  13. Heparin coinfusion during convection-enhanced delivery (CED) increases the distribution of the glial-derived neurotrophic factor (GDNF) ligand family in rat striatum and enhances the pharmacological activity of neurturin. Hamilton, J.F., Morrison, P.F., Chen, M.Y., Harvey-White, J., Pernaute, R.S., Phillips, H., Oldfield, E., Bankiewicz, K.S. Exp. Neurol. (2001) [Pubmed]
  14. NGF but not GDNF or neurturin enhance acetylcholine tissue levels in striatal organotypic brain slices. Fischer, H.P., Marksteiner, J., Ransmayr, G., Saria, A., Humpel, C. Int. J. Dev. Neurosci. (1998) [Pubmed]
  15. Differential expression of mRNAs of GDNF family in the striatum following 6-OHDA-induced lesion. Zhou, J., Yu, Y., Tang, Z., Shen, Y., Xu, L. Neuroreport (2000) [Pubmed]
  16. Responsiveness to neurturin of subpopulations of embryonic rat spinal motoneuron does not correlate with expression of GFR alpha 1 or GFR alpha 2. Garcès, A., Livet, J., Grillet, N., Henderson, C.E., Delapeyrière, O. Dev. Dyn. (2001) [Pubmed]
  17. Cultured olfactory ensheathing cells express nerve growth factor, brain-derived neurotrophic factor, glia cell line-derived neurotrophic factor and their receptors. Woodhall, E., West, A.K., Chuah, M.I. Brain Res. Mol. Brain Res. (2001) [Pubmed]
  18. Neurturin enhances the survival of axotomized retinal ganglion cells in vivo: combined effects with glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor. Koeberle, P.D., Ball, A.K. Neuroscience (2002) [Pubmed]
  19. GDNF family ligands and receptors are differentially regulated after brain insults in the rat. Kokaia, Z., Airaksinen, M.S., Nanobashvili, A., Larsson, E., Kujamäki, E., Lindvall, O., Saarma, M. Eur. J. Neurosci. (1999) [Pubmed]
  20. Quantitative analyses of GFRalpha-1 and GFRalpha-2 mRNAs and tyrosine hydroxylase protein in the nigrostriatal system reveal bilateral compensatory changes following unilateral 6-OHDA lesions in the rat. Kozlowski, D.A., Miljan, E.A., Bremer, E.G., Harrod, C.G., Gerin, C., Connor, B., George, D., Larson, B., Bohn, M.C. Brain Res. (2004) [Pubmed]
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