The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

PSPN  -  persephin

Homo sapiens

Synonyms: PSP, Persephin
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of PSPN

  • In conclusion, it is shown that GDNF but not persephin is a potent proliferation factor for rat glioma cells [1].
  • We have recently examined the MAPT locus in progressive supranuclear palsy and found that a haplotype (H1c) on the background of the well-described H1 clade is associated with PSP [2].
  • Thus, although a decreased PSP/ESV ratio was associated with a higher mortality rate, other clinical and laboratory variables were superior to this index for determining morbidity and mortality in patients with isolated mitral insufficiency [3].
  • Can imaging distinguish PSP from other neurodegenerative disorders [4]?
  • Poorly soluble particles of low toxicity (PSP), such as CB, TiO(2) and coal mine dust, have been demonstrated to cause lung cancer in rodents, being most pronounced in rats [5].

Psychiatry related information on PSPN


High impact information on PSPN

  • The mechanosensory afferents and interneurons are excited by sensory nerve shock, and the components of the resulting LG PSP can be similarly modulated by the same postsynaptic potential changes [10].
  • Here we characterize the human GFRalpha4 as the ligand-binding subunit required together with RET for PSPN signaling [11].
  • GFR alpha-4 and the tyrosine kinase Ret form a functional receptor complex for persephin [12].
  • There were also significant correlations with serum creatinine, blood urea nitrogen, and PSP (r = 0.6, 0.63, and -0.62, respectively) [13].
  • The ratio of peak systolic pressure to end-systolic volume (PSP/ESV) is a measure of contractility that is relatively independent of loading conditions [3].

Chemical compound and disease context of PSPN


Biological context of PSPN


Anatomical context of PSPN

  • In spite of this, PSPN/mGFRalpha4 promotes neurite outgrowth in PC6-3 cells and survival of cerebellar granule neurons [16].
  • NTN and persephin mRNA were not detected in either the fetal spinal cord or the dorsal root ganglia. mRNA coding for GFRalpha-2, however, was found in most cells of the spinal cord gray matter [20].
  • GDNF, neurturin, persephin, nodal, and TGFbeta1 all protected against excitotoxic motor neuron degeneration [21].
  • RSP and PSP stimulated 3H-thymidine incorporation by fibroblasts in a dose-dependent manner [22].
  • The presence of low frequency drives (< 4 Hz) in the bilateral PSP condition and its absence in the bilateral FDI condition is consistent with a bilateral drive to axial, but not distal, musculature by the motor pathways responsible for this oscillatory input [23].

Associations of PSPN with chemical compounds

  • Protein expression analysis using a C-terminal targeted antibody showed that 13 PSP were negative for p21/WAF1 expression after ionizing radiation (6 Gy) or doxorubicin (100 nM) treatment [24].
  • A homology cloning approach targeting conserved motifs present in all serine proteases, was used to identify candidate serine proteases involved in these processes, and revealed 5 genes (acrosin, testisin, neurosin, PSP and neurotrypsin), none of which had been associated previously with expression in endothelial cells [25].
  • Similar values were obtained with the three beta-lactams against PSP but against PRP only the serum of volunteers that had taken amoxycillin exhibited serum bactericidal titres of > or = 8 [26].
  • An interlaboratory exercise has been organized by the CRLMB to evaluate its "fitness for purpose" for the Official Control of PSP toxins in the EU laboratories [27].
  • The PSP S could play that role, since an activity inhibiting the nucleation and growth in vitro of CaCO3 crystals was found in pancreatic juice, associated with these proteins [28].

Other interactions of PSPN

  • In contrast, only NRTN treatment significantly increased 5-HT-ir cells densities at 10 ng/ml (1.3-fold), while an augmentation was seen for GDNF and PSPN at 100 ng/ml (2.4-fold and 1.7-fold, respectively) [29].
  • Unlike GDNF, however, persephin increased neurite outgrowth from oculomotor nuclei in vitro [30].

Analytical, diagnostic and therapeutic context of PSPN

  • Furthermore, neurite outgrowth from pheochromocytoma cells (PC-12), a functional bioassay for NGF-like activity, was stimulated by addition of RSP and PSP to the culture media of the PC-12 cells [22].
  • Subsequently, a Western blot analysis with the NGF antibody identified two immunoreactive bands of 41 +/- 2 kDa and 51 +/- 1 kDa in both RSP and PSP under reduced conditions [22].
  • The present study provides new insight into the molecular mechanisms involved in PSP-induced apoptosis in leukemic HL-60 cells analyzed by cDNA microarray [31].
  • METHODS: We performed a retrospective analysis on 126 consecutive video-assisted thoracoscopic surgery (VATS) procedures in 113 patients treated for stage I recurrent PSP between January 1994 and December 2001 [32].
  • The HPLC validated method is only applicable for Official PSP Control for certain samples [27].


  1. Glial cell line-derived neurotrophic factor (GDNF) is a proliferation factor for rat C6 glioma cells: evidence from antisense experiments. Wiesenhofer, B., Weis, C., Humpel, C. Antisense Nucleic Acid Drug Dev. (2000) [Pubmed]
  2. The H1c haplotype at the MAPT locus is associated with Alzheimer's disease. Myers, A.J., Kaleem, M., Marlowe, L., Pittman, A.M., Lees, A.J., Fung, H.C., Duckworth, J., Leung, D., Gibson, A., Morris, C.M., de Silva, R., Hardy, J. Hum. Mol. Genet. (2005) [Pubmed]
  3. Natural history of chronic mitral insufficiency: relation of peak systolic pressure/end-systolic volume ratio to morbidity and mortality. Ramanathan, K.B., Knowles, J., Connor, M.J., Tribble, R., Kroetz, F.W., Sullivan, J.M., Mirvis, D.M. J. Am. Coll. Cardiol. (1984) [Pubmed]
  4. Can imaging distinguish PSP from other neurodegenerative disorders? Eidelberg, D., Dhawan, V. Neurology (2002) [Pubmed]
  5. Inhaled particles and lung cancer, part B: paradigms and risk assessment. Borm, P.J., Schins, R.P., Albrecht, C. Int. J. Cancer (2004) [Pubmed]
  6. Pin1 colocalization with phosphorylated tau in Alzheimer's disease and other tauopathies. Ramakrishnan, P., Dickson, D.W., Davies, P. Neurobiol. Dis. (2003) [Pubmed]
  7. Deficits in long-term retention of learned motor skills in patients with cortical or subcortical degeneration. Mochizuki-Kawai, H., Kawamura, M., Hasegawa, Y., Mochizuki, S., Oeda, R., Yamanaka, K., Tagaya, H. Neuropsychologia. (2004) [Pubmed]
  8. Non-Fluent Progressive Aphasia, Depression, and OCD in a Woman With Progressive Supranuclear Palsy: Neuroanatomical and Neuropathological Correlations. Karnik, N.S., D'Apuzzo, M., Greicius, M. Neurocase : case studies in neuropsychology, neuropsychiatry, and behavioural neurology (2006) [Pubmed]
  9. Development of a multi-channel exploratory battery for psychophysiological assessment: the Stress Profile. Diaz, M.I., Vallejo, M.A., Comeche, M.I. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. (2003) [Pubmed]
  10. Postsynaptic modulation of rectifying electrical synaptic inputs to the LG escape command neuron in crayfish. Edwards, D.H., Heitler, W.J., Leise, E.M., Fricke, R.A. J. Neurosci. (1991) [Pubmed]
  11. Human glial cell line-derived neurotrophic factor receptor alpha 4 is the receptor for persephin and is predominantly expressed in normal and malignant thyroid medullary cells. Lindahl, M., Poteryaev, D., Yu, L., Arumae, U., Timmusk, T., Bongarzone, I., Aiello, A., Pierotti, M.A., Airaksinen, M.S., Saarma, M. J. Biol. Chem. (2001) [Pubmed]
  12. GFR alpha-4 and the tyrosine kinase Ret form a functional receptor complex for persephin. Enokido, Y., de Sauvage, F., Hongo, J.A., Ninkina, N., Rosenthal, A., Buchman, V.L., Davies, A.M. Curr. Biol. (1998) [Pubmed]
  13. Relationship between insulin response to oral glucose load and creatinine clearance. Yasuda, K., Sato, T., Furuyama, T., Yashinaga, K. Diabetes (1975) [Pubmed]
  14. Immune enhancement of a polysaccharides peptides isolated from Coriolus versicolor. Li, X.Y., Wang, J.F., Zhu, P.P., Liu, L., Ge, J.B., Yang, S.X. Zhongguo yao li xue bao = Acta pharmacologica Sinica. (1990) [Pubmed]
  15. Tissue distribution of neurturin, persephin and artemin in the human brainstem at fetal, neonatal and adult age. Quartu, M., Serra, M.P., Boi, M., Sestu, N., Lai, M.L., Del Fiacco, M. Brain Res. (2007) [Pubmed]
  16. PSPN/GFRalpha4 has a significantly weaker capacity than GDNF/GFRalpha1 to recruit RET to rafts, but promotes neuronal survival and neurite outgrowth. Yang, J., Lindahl, M., Lindholm, P., Virtanen, H., Coffey, E., Runeberg-Roos, P., Saarma, M. FEBS Lett. (2004) [Pubmed]
  17. Loss of neurturin in frog-Comparative genomics study of GDNF family ligand-receptor pairs. Hätinen, T., Holm, L., Airaksinen, M.S. Mol. Cell. Neurosci. (2007) [Pubmed]
  18. Polymorphisms in the initiators of RET (rearranged during transfection) signaling pathway and susceptibility to sporadic medullary thyroid carcinoma. Cebrian, A., Lesueur, F., Martin, S., Leyland, J., Ahmed, S., Luccarini, C., Smith, P.L., Luben, R., Whittaker, J., Pharoah, P.D., Dunning, A.M., Ponder, B.A. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  19. Assignment of persephin (PSPN), a human neurotrophic factor, to chromosome 19p13.3 by radiation hybrid mapping and somatic cell hybrid PCR. Chadwick, B.P., Helbling, L.A., Angrist, M., Chakravarti, A., Gusella, J.F., Slaugenhaupt, S.A. Cytogenet. Cell Genet. (1998) [Pubmed]
  20. GDNF, RET and GFRalpha-1-3 mRNA expression in the developing human spinal cord and ganglia. Widenfalk, J., Widmer, H.R., Spenger, C. Neuroreport (1999) [Pubmed]
  21. TGFbeta trophic factors differentially modulate motor axon outgrowth and protection from excitotoxicity. Ho, T.W., Bristol, L.A., Coccia, C., Li, Y., Milbrandt, J., Johnson, E., Jin, L., Bar-Peled, O., Griffin, J.W., Rothstein, J.D. Exp. Neurol. (2000) [Pubmed]
  22. Germ cell mitogenic activity is associated with nerve growth factor-like protein(s). Onoda, M., Pflug, B., Djakiew, D. J. Cell. Physiol. (1991) [Pubmed]
  23. The unilateral and bilateral control of motor unit pairs in the first dorsal interosseous and paraspinal muscles in man. Marsden, J.F., Farmer, S.F., Halliday, D.M., Rosenberg, J.R., Brown, P. J. Physiol. (Lond.) (1999) [Pubmed]
  24. A p21/WAF1 mutation favors the appearance of drug resistance to paclitaxel in human noncancerous epithelial mammary cells. Galmarini, C.M., Bouchet, B.P., Audoynaud, C., Lamblot, C., Falette, N., Bertholon, J., Wang, Q., Beghin, A., Dumontet, C., Puisieux, A. Int. J. Cancer (2006) [Pubmed]
  25. Endothelial cell serine proteases expressed during vascular morphogenesis and angiogenesis. Aimes, R.T., Zijlstra, A., Hooper, J.D., Ogbourne, S.M., Sit, M.L., Fuchs, S., Gotley, D.C., Quigley, J.P., Antalis, T.M. Thromb. Haemost. (2003) [Pubmed]
  26. In-vitro, in-vivo and ex-vivo studies with oral beta-lactams against Streptococcus pneumoniae. Pérez-Trallero, E., Alkorta, M., García-Arenzana, J.M., Iturzaeta, A., Gomariz, M. J. Antimicrob. Chemother. (1998) [Pubmed]
  27. Influence of the sample toxic profile on the suitability of a high performance liquid chromatography method for official paralytic shellfish toxins control. Ben-Gigirey, B., Rodr??guez-Velasco, M.L., Villar-Gonz??lez, A., Botana, L.M. Journal of chromatography. A (2007) [Pubmed]
  28. The human pancreatic stone protein. De Caro, A., Multigner, L., Dagorn, J.C., Sarles, H. Biochimie (1988) [Pubmed]
  29. GDNF family ligands display distinct action profiles on cultured GABAergic and serotonergic neurons of rat ventral mesencephalon. Ducray, A., Krebs, S.H., Schaller, B., Seiler, R.W., Meyer, M., Widmer, H.R. Brain Res. (2006) [Pubmed]
  30. GDNF increases the survival of developing oculomotor neurons through a target-derived mechanism. Chen, J., Butowt, R., Rind, H.B., von Bartheld, C.S. Mol. Cell. Neurosci. (2003) [Pubmed]
  31. Molecular characterization of Coriolus versicolor PSP-induced apoptosis in human promyelotic leukemic HL-60 cells using cDNA microarray. Zeng, F., Hon, C.C., Sit, W.H., Chow, K.Y., Hui, R.K., Law, I.K., Ng, V.W., Yang, X.T., Leung, F.C., Wan, J.M. Int. J. Oncol. (2005) [Pubmed]
  32. Lung wedge resection improves outcome in stage I primary spontaneous pneumothorax. Czerny, M., Salat, A., Fleck, T., Hofmann, W., Zimpfer, D., Eckersberger, F., Klepetko, W., Wolner, E., Mueller, M.R. Ann. Thorac. Surg. (2004) [Pubmed]
WikiGenes - Universities