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Gene Review

Pspn  -  persephin

Mus musculus

Synonyms: PSP, Persephin
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Disease relevance of Pspn


High impact information on Pspn

  • Our findings support the view that PSP signaling can exert an important control function in the context of stroke and glutamate-mediated neurotoxicity, and also suggest that future therapeutic approaches may involve this novel trophic protein [1].
  • Taken together, these data indicate that PSP is a potent modulator of excitotoxicity in the central nervous system with pronounced neuroprotective activity [1].
  • Human glial cell line-derived neurotrophic factor receptor alpha 4 is the receptor for persephin and is predominantly expressed in normal and malignant thyroid medullary cells [4].
  • Neurturin, artemin and persephin are homologs of GDNF, and their impact on axonal regeneration in adults has not been studied yet [2].
  • Glial cell line-derived neurotrophic factor family receptor (GFRalpha) 4, the binding receptor for persephin, is coexpressed with the signaling Ret receptor tyrosine kinase predominantly in thyroid calcitonin-producing C cells [5].

Biological context of Pspn

  • However, in 33% of cells studied in Kcna1-null slices bathed in normal extracellular medium, orthodromic stimulation evoked synaptically driven bursts of action potentials that followed a short-latency excitatory postsynaptic potential (EPSP)-inhibitory PSP (IPSP) sequence [6].
  • Although it is clear that female sexual behavior, including pacing behavior, is important for induction of P/PSP, there has been no concerted effort to examine whether or how common mechanisms may control both functions [7].
  • High-level parotid gland expression of the PSP gene was indicated to depend on a novel regulatory region situated between -8.0 and -6.5 kb [8].
  • This region was shown to activate a heterologus SV40 early promoter in the parotid glands of transgenic mice, suggesting that the PSP gene is controlled by enhancer sequences [8].
  • This paper will review both new and old data that address the question of whether brain mechanisms involved in reproductive function act in a coordinated way to control female sexual behavior and the induction of pregnancy/pseudopregnancy (P/PSP) by vaginocervical stimulation [7].

Anatomical context of Pspn


Associations of Pspn with chemical compounds

  • PSP toxin, anatoxin-a, homoanatoxin-a and microcystins were not detected when pond water from a diseased pond was tested [11].
  • Spatial and temporal evolution of PSP toxins along the Atlantic shore of Morocco [12].
  • NIH/Ola mice were given two intraperitoneal injections with ovalbumin (OVA; 10 microg) alone or OVA in combination with PSP, polytetrafluoroethylene (teflon), titanium dioxide (TiO(2)) or amorphous silica particles (2.8x10(10)-2.8x10(12)) [13].

Other interactions of Pspn


  1. Effects of cerebral ischemia in mice deficient in Persephin. Tomac, A.C., Agulnick, A.D., Haughey, N., Chang, C.F., Zhang, Y., Bäckman, C., Morales, M., Mattson, M.P., Wang, Y., Westphal, H., Hoffer, B.J. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. GDNF family ligands activate multiple events during axonal growth in mature sensory neurons. Paveliev, M., Airaksinen, M.S., Saarma, M. Mol. Cell. Neurosci. (2004) [Pubmed]
  3. Study of paralytic shellfish poisoning toxin profile in shellfish from the Mediterranean shore of Morocco. Taleb, H., Vale, P., Jaime, E., Blaghen, M. Toxicon (2001) [Pubmed]
  4. Human glial cell line-derived neurotrophic factor receptor alpha 4 is the receptor for persephin and is predominantly expressed in normal and malignant thyroid medullary cells. Lindahl, M., Poteryaev, D., Yu, L., Arumae, U., Timmusk, T., Bongarzone, I., Aiello, A., Pierotti, M.A., Airaksinen, M.S., Saarma, M. J. Biol. Chem. (2001) [Pubmed]
  5. Ablation of persephin receptor glial cell line-derived neurotrophic factor family receptor alpha4 impairs thyroid calcitonin production in young mice. Lindfors, P.H., Lindahl, M., Rossi, J., Saarma, M., Airaksinen, M.S. Endocrinology (2006) [Pubmed]
  6. Hyperexcitability of CA3 pyramidal cells in mice lacking the potassium channel subunit Kv1.1. Lopantsev, V., Tempel, B.L., Schwartzkroin, P.A. Epilepsia (2003) [Pubmed]
  7. Co-regulation of female sexual behavior and pregnancy induction: an exploratory synthesis. Erskine, M.S., Lehmann, M.L., Cameron, N.M., Polston, E.K. Behav. Brain Res. (2004) [Pubmed]
  8. The main regulatory region in the murine PSP gene is a parotid gland enhancer. Laursen, J., Krogh-Pedersen, H., Dagnaes-Hansen, F., Hjorth, J.P. Transgenic Res. (1998) [Pubmed]
  9. GDNF family members and their receptors: expression and functions in two oligodendroglial cell lines representing distinct stages of oligodendroglial development. Strelau, J., Unsicker, K. Glia (1999) [Pubmed]
  10. Fungal polysaccharopeptide inhibits tumor angiogenesis and tumor growth in mice. Ho, J.C., Konerding, M.A., Gaumann, A., Groth, M., Liu, W.K. Life Sci. (2004) [Pubmed]
  11. Toxic effects of blooms of marine species of Oscillatoriales on farmed prawns (Penaeus monodon, Penaeus japonicus) and brine shrimp (Artemia salina). Smith, P.T. Toxicon (1996) [Pubmed]
  12. Spatial and temporal evolution of PSP toxins along the Atlantic shore of Morocco. Taleb, H., Vale, P., Blaghen, M. Toxicon (2003) [Pubmed]
  13. Fine particles of widely different composition have an adjuvant effect on the production of allergen-specific antibodies. Granum, B., Gaarder, P.I., Groeng, E., Leikvold, R., Namork, E., Lovik, M. Toxicol. Lett. (2001) [Pubmed]
  14. Glycosaminoglycans in the study of mammalian organ development. Davies, J.A., Fisher, C.E., Barnett, M.W. Biochem. Soc. Trans. (2001) [Pubmed]
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