Disease relevance of Bmp3

• Sequence and expression of bone morphogenetic protein 3 mRNA in prolonged cultures of fetal rat calvarial osteoblasts and in rat prostate adenocarcinoma PA III cells [1].
• Bone morphogenetic protein 3 expression pattern in rat condylar cartilage, femoral cartilage and mandibular fracture callus [2].
• Previously, we showed that BMP-3 mRNA is expressed in normal and neoplastic rat and human prostate tissues, and in human osteosarcoma cells, as multiple transcripts [1].
• To compare the nature of these transcripts in different tissues, three cDNA clones encoding BMP-3 have been isolated by reverse transcription-polymerase chain reaction (RT-PCR) and cDNA library screening from human prostate cancer PC-3 cells, rat prostate adenocarcinoma PA III cells, and primary FRC cells [1].

High impact information on Bmp3

• In this study, we aimed to examine the involvement of BMP-2, BMP-3, BMP-4, and BMP-7 expression in ESW promotion of fracture healing [3].
• Using in situ hybridization, we localized mRNAs for BMP-3 and BMP-7 during organogenesis in rats [4].
• The temporospatial expression of BMPs and receptors at the injured growth plate suggests potential involvement of BMP-3 and -4 in regulating the inflammatory response or as its mediators in modulating downstream events, and BMP-2, -3, -4, and -7 in the fibrogenic and osteogenic responses, and BMP-7 in bone remodeling at the injured growth plate [5].
• BMP-3b (also called GDF-10) is a novel BMP-3-related protein recently discovered in rat femur tissue [6].
• The deduced amino acid sequence of rat BMP-3 in the mature region reveals 2 amino acid changes compared to that of human BMP-3 (98% identity) [7].

Biological context of Bmp3

• We also found that Bmp3 was expressed in the periosteal layers of the bone segments near the fracture site during fracture healing [2].
• Furthermore, in remodeling bone, Bmp3 mRNA was strongly expressed in active osteoblast cells in periosteal reaction layers formed after fracture [2].
• The deduced BMP-3b amino acid sequence shows 81% similarity with the mature region of rat BMP-3 and only 37% similarity with the propeptide region [7].
• Analysis of these clones has revealed that the nucleotide sequence of BMP-3 found in human prostate cells is identical to that found in human bone cells [1].
• BMP-3 mRNA expression has a distinct temporal pattern during bone cell differentiation of FRC osteoblasts [1].

Anatomical context of Bmp3

• Bmp3 was also found in hypertrophic chondrocytes that expressed type X collagen mRNA in all cartilages evaluated [2].
• These findings suggest that Bmp3 expression in a special layer of typical articular cartilage may be regulated by mechanical stress stimulation [2].
• BMP-3 mRNA was found in femur, calvaria, trachea, lung and ovary [7].
• Expression and possible mechanisms of regulation of BMP3 in rat cranial sutures [8].
• Spatial and temporal localisation of bone morphogenetic protein-3 (osteogenin) in the developing rat submandibular gland [9].

Associations of Bmp3 with chemical compounds

• The volumes of induced bone were similar for BMP-3-coated pure Ti and HA implants, while CB implants were significantly less active [10].

Other interactions of Bmp3

• Identification of rat bone morphogenetic protein-3b (BMP-3b), a new member of BMP-3 [7].

Analytical, diagnostic and therapeutic context of Bmp3

• Here we compare the effects of BMP3, 5, 6, and 7 and GDF5 and 6 in a rat mesencephalic cell culture system that reflects the developmental stage of neurons around birth [11].

References