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Gene Review

BMP3  -  bone morphogenetic protein 3

Homo sapiens

Synonyms: BMP-3, BMP-3A, BMP3A, Bone morphogenetic protein 3, Bone morphogenetic protein 3A, ...
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Disease relevance of BMP3


High impact information on BMP3

  • Two of the encoded proteins (BMP-2A and BMP-3) are new members of the TGF-beta supergene family, while the third, BMP-1, appears to be a novel regulatory molecule [6].
  • Both osteogenin and rhBMP-2B at higher concentrations (0.1-30 ng/ml) stimulated mRNA expression for an additional regulatory molecule, type beta 1 transforming growth factor (TGF-beta 1) in human monocytes [7].
  • Our results demonstrate that osteogenin and related BMPs through their profound effects on monocyte recruitment and cytokine synthesis may promote additional successive steps in the endochondral bone formation cascade [7].
  • Osteogenin and recombinant bone morphogenetic protein 2B are chemotactic for human monocytes and stimulate transforming growth factor beta 1 mRNA expression [7].
  • The influence of osteogenin, purified from bovine bone, and of recombinant human bone morphogenetic protein-2B (BMP-2B) has been examined in bovine articular cartilage explants [8].

Biological context of BMP3


Anatomical context of BMP3

  • When a human bone marrow stromal cell (HBMSC) culture was treated simultaneously with 1,25(OH)2D3 (10(-8) M) and BMP3 (2.5 ng/ml), the total osteocalcin content in the cell layer and in the culture medium was higher than when the culture was treated with either factor alone (162%) [13].
  • Opposing actions of BMP3 and TGF beta 1 in human bone marrow stromal cell growth and differentiation [14].
  • A lot of reports have studied the presence of BMPs and their effects on bone marker expression in many different cell lines, however none describe the regulation of BMP3 by different factors and expression conditions [13].
  • Osteogenin has been purified to homogeneity from bovine bone matrix and the sequences of several tryptic peptides have been determined [9].
  • Stimulation of osteoblasts with recombinant human fibroblast growth factor 2 led to a rapid and sustained suppression of BMP3 expression (85 percent, p < 0.01) when compared with controls [11].

Associations of BMP3 with chemical compounds


Other interactions of BMP3

  • This analysis reveals that the BMP2A and BMP3 genes map to conserved regions between mouse and human, while the BMP1 gene does not [17].
  • After electrophoresis, RNA were blotted onto a nylon membrane and incubated with 32P-labeled BMP3 and GAPDH riboprobes [13].
  • The carboxyl-terminal quarter of osteogenin has sequence identity to the corresponding regions of two related proteins BMP-2A and BMP-2B [9].
  • Osteogenin fractions, with osteogenic activity in rats, were chromatographically adsorbed onto porous hydroxyapatites and implanted intramuscularly in baboons (Papio ursinus) [18].
  • These results suggested that a number of candidate genes located in the excluded regions, such as the growth hormone (GH) gene, tumor necrosis factor-alpha (TNF-alpha) gene, and bone morphogenetic protein-3 (BMP3) gene, are unlikely to have a substantial effect on bone size variation in this Caucasian population [19].

Analytical, diagnostic and therapeutic context of BMP3


  1. Expression of bone morphogenetic protein messenger RNAs by normal rat and human prostate and prostate cancer cells. Harris, S.E., Harris, M.A., Mahy, P., Wozney, J., Feng, J.Q., Mundy, G.R. Prostate (1994) [Pubmed]
  2. Expression of bone morphogenetic proteins and cartilage-derived morphogenetic proteins during osteophyte formation in humans. Zoricic, S., Maric, I., Bobinac, D., Vukicevic, S. J. Anat. (2003) [Pubmed]
  3. Initiation of bone regeneration in adult baboons by osteogenin, a bone morphogenetic protein. Ripamonti, U., Ma, S., Cunningham, N.S., Yeates, L., Reddi, A.H. Matrix (1992) [Pubmed]
  4. Collagen-targeted BMP3 fusion proteins arrayed on collagen matrices or porous ceramics impregnated with Type I collagen enhance osteogenesis in a rat cranial defect model. Han, B., Perelman, N., Tang, B., Hall, F., Shors, E.C., Nimni, M.E. J. Orthop. Res. (2002) [Pubmed]
  5. Reciprocal action between BMP-2 and BMP-3 in cultured fibroblast in vitro. Meng, G.L., Hu, Y.Y., Pu, Q., Lu, R., Yang, L., Wang, J., Bai, J.P., Xu, X.Z., Li, D. Chinese journal of traumatology = Zhonghua chuang shang za zhi / Chinese Medical Association. (2003) [Pubmed]
  6. Novel regulators of bone formation: molecular clones and activities. Wozney, J.M., Rosen, V., Celeste, A.J., Mitsock, L.M., Whitters, M.J., Kriz, R.W., Hewick, R.M., Wang, E.A. Science (1988) [Pubmed]
  7. Osteogenin and recombinant bone morphogenetic protein 2B are chemotactic for human monocytes and stimulate transforming growth factor beta 1 mRNA expression. Cunningham, N.S., Paralkar, V., Reddi, A.H. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  8. Natural bovine osteogenin and recombinant human bone morphogenetic protein-2B are equipotent in the maintenance of proteoglycans in bovine articular cartilage explant cultures. Luyten, F.P., Yu, Y.M., Yanagishita, M., Vukicevic, S., Hammonds, R.G., Reddi, A.H. J. Biol. Chem. (1992) [Pubmed]
  9. Advances in osteogenin and related bone morphogenetic proteins in bone induction and repair. Luyten, F.P., Cunningham, N.S., Vukicevic, S., Paralkar, V., Ripamonti, U., Reddi, A.H. Acta orthopaedica Belgica. (1992) [Pubmed]
  10. Localization of a locus responsible for the bovine chondrodysplastic dwarfism (bcd) on chromosome 6. Yoneda, K., Moritomo, Y., Takami, M., Hirata, S., Kikukawa, Y., Kunieda, T. Mamm. Genome (1999) [Pubmed]
  11. Expression and possible mechanisms of regulation of BMP3 in rat cranial sutures. Nacamuli, R.P., Fong, K.D., Lenton, K.A., Song, H.M., Fang, T.D., Salim, A., Longaker, M.T. Plast. Reconstr. Surg. (2005) [Pubmed]
  12. Molecular profile of catabolic versus anabolic treatment regimens of parathyroid hormone (PTH) in rat bone: an analysis by DNA microarray. Onyia, J.E., Helvering, L.M., Gelbert, L., Wei, T., Huang, S., Chen, P., Dow, E.R., Maran, A., Zhang, M., Lotinun, S., Lin, X., Halladay, D.L., Miles, R.R., Kulkarni, N.H., Ambrose, E.M., Ma, Y.L., Frolik, C.A., Sato, M., Bryant, H.U., Turner, R.T. J. Cell. Biochem. (2005) [Pubmed]
  13. Effect of 1,25(OH)2D3 on bone morphogenetic protein-3 mRNA expression. Faucheux, C., Bareille, R., Amédée, J., Triffitt, J.T. J. Cell. Biochem. (1999) [Pubmed]
  14. Opposing actions of BMP3 and TGF beta 1 in human bone marrow stromal cell growth and differentiation. Faucheux, C., Ulysse, F., Bareille, R., Reddi, A.H., Amédée, J. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  15. Growth and morphogenetic factors in bone induction: role of osteogenin and related bone morphogenetic proteins in craniofacial and periodontal bone repair. Ripamonti, U., Reddi, A.H. Crit. Rev. Oral Biol. Med. (1992) [Pubmed]
  16. Osteogenin (bone morphogenic protein 3) inhibits proliferation and stimulates differentiation of osteoprogenitors in human bone marrow. Amédée, J., Bareille, R., Rouais, F., Cunningham, N., Reddi, H., Harmand, M.F. Differentiation (1994) [Pubmed]
  17. Bone morphogenetic protein: chromosomal localization of human genes for BMP1, BMP2A, and BMP3. Tabas, J.A., Zasloff, M., Wasmuth, J.J., Emanuel, B.S., Altherr, M.R., McPherson, J.D., Wozney, J.M., Kaplan, F.S. Genomics (1991) [Pubmed]
  18. Initiation of heterotopic osteogenesis in primates after chromatographic adsorption of osteogenin, a bone morphogenetic protein, onto porous hydroxyapatite. Ripamonti, U., Yeates, L., van den Heever, B. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  19. Linkage exclusion mapping with bone size in 79 Caucasian pedigrees. Chen, X.D., Shen, H., Recker, R.R., Deng, H.W. J. Bone Miner. Metab. (2006) [Pubmed]
  20. Identification of ovarian granulosa cells as a novel site of expression for bone morphogenetic protein-3 (BMP-3/osteogenin) and regulation of BMP-3 messenger ribonucleic acids by chorionic gonadotropin in cultured human granulosa-luteal cells. Jaatinen, R., Rosen, V., Tuuri, T., Ritvos, O. J. Clin. Endocrinol. Metab. (1996) [Pubmed]
  21. Developing human lung and kidney are major sites for synthesis of bone morphogenetic protein-3 (osteogenin). Vukicevic, S., Helder, M.N., Luyten, F.P. J. Histochem. Cytochem. (1994) [Pubmed]
  22. Purification and molecular cloning of a novel group of BMPs and localization of BMP mRNA in developing bone. Rosen, V., Wozney, J.M., Wang, E.A., Cordes, P., Celeste, A., McQuaid, D., Kurtzberg, L. Connect. Tissue Res. (1989) [Pubmed]
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