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Gene Review

Hnf4a  -  hepatocyte nuclear factor 4, alpha

Rattus norvegicus

Synonyms: HNF-4-alpha, Hepatocyte nuclear factor 4-alpha, Hnf-4, Hnf4, Hnf4alpha, ...
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Disease relevance of Hnf4a

  • Therefore, the regulatory effect of the C9-Met-DNA is exerted, at least in part, by a CAAAG sequence that can sequester the endogenous inhibitory Tcf-4 and thereby promote transcription of osteopontin, the direct effector of metastasis in this system [1].
  • IL-1 beta antagonists or proteasome inhibitors might increase HNF-4 alpha protein levels in the acute-phase response, which could result in increased liver function and survival [2].
  • We conclude that the decrease in HNF-4 alpha that occurs in vivo after the administration of LPS may be the result of IL-1 beta-induced degradation, and likely contributes to the liver insufficiency that occurs [2].
  • ACBP overexpression in COS-7 or rat hepatoma cells enhanced transactivation of an HNF-4 alpha-dependent luciferase reporter plasmid by 3.2- and 1.6-fold, respectively [3].

High impact information on Hnf4a


Biological context of Hnf4a


Anatomical context of Hnf4a


Other interactions of Hnf4a


Analytical, diagnostic and therapeutic context of Hnf4a


  1. Metastasis-inducing dna regulates the expression of the osteopontin gene by binding the transcription factor Tcf-4. El-Tanani, M., Barraclough, R., Wilkinson, M.C., Rudland, P.S. Cancer Res. (2001) [Pubmed]
  2. Lipopolysaccharide results in a marked decrease in hepatocyte nuclear factor 4 alpha in rat liver. Wang, B., Cai, S.R., Gao, C., Sladek, F.M., Ponder, K.P. Hepatology (2001) [Pubmed]
  3. Physical and functional interaction of Acyl-CoA-binding protein with hepatocyte nuclear factor-4 alpha. Petrescu, A.D., Payne, H.R., Boedecker, A., Chao, H., Hertz, R., Bar-Tana, J., Schroeder, F., Kier, A.B. J. Biol. Chem. (2003) [Pubmed]
  4. Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Sladek, F.M., Zhong, W.M., Lai, E., Darnell, J.E. Genes Dev. (1990) [Pubmed]
  5. Isotretinoin and fenofibrate induce adiposity with distinct effect on metabolic profile in a rat model of the insulin resistance syndrome. Sedova, L., Seda, O., Krenova, D., Kren, V., Kazdova, L. Int. J. Obes. Relat. Metab. Disord. (2004) [Pubmed]
  6. A role for the beta-catenin/T-cell factor signaling cascade in vascular remodeling. Wang, X., Xiao, Y., Mou, Y., Zhao, Y., Blankesteijn, W.M., Hall, J.L. Circ. Res. (2002) [Pubmed]
  7. Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand. Dhe-Paganon, S., Duda, K., Iwamoto, M., Chi, Y.I., Shoelson, S.E. J. Biol. Chem. (2002) [Pubmed]
  8. Improved performance of primary rat hepatocytes on blended natural polymers. Li, K., Qu, X., Wang, Y., Tang, Y., Qin, D., Wang, Y., Feng, M. Journal of biomedical materials research. Part A. (2005) [Pubmed]
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