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Gene Review

tet  -  tetracycline resistance protein

Staphylococcus aureus

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Disease relevance of tet


High impact information on tet


Chemical compound and disease context of tet


Biological context of tet


Anatomical context of tet


Associations of tet with chemical compounds

  • Induction of the tet gene by tetracycline resulted in a 4-fold increase in the levels of TET mRNA and at least a 15-fold increase in the amount of TET protein in B. subtilis minicells [1].
  • For a selection of 24 Tc(r) lactic acid bacterial isolates displaying unique (GTG)(5)-PCR fingerprints, tet genes were determined by means of PCR, and only tet(M) was detected [2].
  • In order to express the pNS1-encoded TET as a fused product, a 0.8 kilobase pairs fragment containing 57.1% of tet determinant was inserted into a chloramphenicol resistance determinant [18].
  • A unique DNA structure of the junction of homologous and nonhomologous regions between tetracycline-resistance plasmid pNS1981 and kanamycin-resistance plasmid pUB110 [19].
  • Presence of tetracycline resistance determinants and susceptibility to tigecycline and minocycline [10].

Analytical, diagnostic and therapeutic context of tet

  • Northern blot hybridizations demonstrated that the tet gene encodes a single mRNA, and its initiation site has been mapped by S1 nuclease protection experiments [1].
  • We demonstrate by restriction mapping analysis that pAM alpha 1 delta 1 is virtually identical to a 4.6-kilobase tetracycline resistance plasmid of Bacillus cereus, pBC16, which is known to show extensive homology to plasmid isolates from Staphylococcus species (such as pUB110), as well as from other Bacillus species [20].


  1. Characterization of the tetracycline resistance gene of plasmid pT181 of Staphylococcus aureus. Mojumdar, M., Khan, S.A. J. Bacteriol. (1988) [Pubmed]
  2. Molecular characterization of tet(M) genes in Lactobacillus isolates from different types of fermented dry sausage. Gevers, D., Danielsen, M., Huys, G., Swings, J. Appl. Environ. Microbiol. (2003) [Pubmed]
  3. Case studies in current drug development: 'glycylcyclines'. Sum, P.E. Current opinion in chemical biology. (2006) [Pubmed]
  4. Nucleotide sequence of the tetM tetracycline resistance determinant of the streptococcal conjugative shuttle transposon Tn1545. Martin, P., Trieu-Cuot, P., Courvalin, P. Nucleic Acids Res. (1986) [Pubmed]
  5. Isolation and characterization of tetracycline resistance proteins from Staphylococcus aureus and Escherichia coli. Wojdani, A., Avtalion, R.R., Sompolinsky, D. Antimicrob. Agents Chemother. (1976) [Pubmed]
  6. Replication of single-stranded plasmid pT181 DNA in vitro. Birch, P., Khan, S.A. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  7. Mercury and tetracycline resistance genes and flanking repeats associated with methicillin resistance on the chromosome of Staphylococcus aureus. Skinner, S., Inglis, B., Matthews, P.R., Stewart, P.R. Mol. Microbiol. (1988) [Pubmed]
  8. An occurrence of a noticeable alternating pyrimidine-purine run in the replication origins of tetracycline-resistance plasmids pNSI and pT181. Shishido, K. Nucleic Acids Res. (1988) [Pubmed]
  9. Molecular requirements for the inhibition of the tetracycline antiport protein and the effect of potent inhibitors on the growth of tetracycline-resistant bacteria. Nelson, M.L., Park, B.H., Levy, S.B. J. Med. Chem. (1994) [Pubmed]
  10. Presence of tetracycline resistance determinants and susceptibility to tigecycline and minocycline. Fluit, A.C., Florijn, A., Verhoef, J., Milatovic, D. Antimicrob. Agents Chemother. (2005) [Pubmed]
  11. A novel MATE family efflux pump contributes to the reduced susceptibility of laboratory-derived Staphylococcus aureus mutants to tigecycline. McAleese, F., Petersen, P., Ruzin, A., Dunman, P.M., Murphy, E., Projan, S.J., Bradford, P.A. Antimicrob. Agents Chemother. (2005) [Pubmed]
  12. Characterization and construction of molecular cloning vehicles within Staphylococcus aureus. Wilson, C.R., Baldwin, N.J. J. Bacteriol. (1978) [Pubmed]
  13. Genetic linkage of chromosomal tetracycline resistance and pigmentation to a purine auxotrophic marker and the isoleucine-valine-leucine structural genes in Staphylococcus aureus. Pattee, P.A. J. Bacteriol. (1976) [Pubmed]
  14. Complete nucleotide sequence of pT181, a tetracycline-resistance plasmid from Staphylococcus aureus. Khan, S.A., Novick, R.P. Plasmid (1983) [Pubmed]
  15. Inducible antisense RNA expression in the characterization of gene functions in Streptococcus mutans. Wang, B., Kuramitsu, H.K. Infect. Immun. (2005) [Pubmed]
  16. Nucleotide sequence and phylogeny of the tet(L) tetracycline resistance determinant encoded by plasmid pSTE1 from Staphylococcus hyicus. Schwarz, S., Cardoso, M., Wegener, H.C. Antimicrob. Agents Chemother. (1992) [Pubmed]
  17. Transfer of the conjugal tetracycline resistance transposon Tn916 from Streptococcus faecalis to Staphylococcus aureus and identification of some insertion sites in the staphylococcal chromosome. Jones, J.M., Yost, S.C., Pattee, P.A. J. Bacteriol. (1987) [Pubmed]
  18. Expression of a restricted fragment of staphylococcal tetracycline resistance determinant as a fused product in Escherichia coli. Aoki, T., Amauchi, K., Watabe, H. Chem. Pharm. Bull. (1991) [Pubmed]
  19. A unique DNA structure of the junction of homologous and nonhomologous regions between tetracycline-resistance plasmid pNS1981 and kanamycin-resistance plasmid pUB110. Sakaguchi, R., Shishido, K. Nucleic Acids Res. (1987) [Pubmed]
  20. Streptococcus plasmid pAM alpha 1 is a composite of two separable replicons, one of which is closely related to Bacillus plasmid pBC16. Perkins, J.B., Youngman, P. J. Bacteriol. (1983) [Pubmed]
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