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Gene Review

ADCY10  -  adenylate cyclase 10 (soluble)

Homo sapiens

Synonyms: AH-related protein, Adenylate cyclase homolog, Adenylate cyclase type 10, Germ cell soluble adenylyl cyclase, HCA2, ...
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Disease relevance of SAC


High impact information on SAC

  • Crosslinkage of the B cell antigen receptor by anti-mu beads or SAC results in the selective induction of hsp70 [6].
  • This is in contrast to B cell differentiation signals of IL-2 alone or SAC and IL-2 in concert [7].
  • The idea that both the substrate and the enzyme contribute to catalysis (substrate assisted catalysis; SAC) is applicable to guanine nucleotide-binding proteins (G proteins) [8].
  • In polarized HepG2 cells an endosomal organelle, SAC, fulfills a prominent role in the biogenesis of the canalicular membrane, reflected by its ability to sort and redistribute apical and basolateral sphingolipids [9].
  • Thus, for normal differentiation of human B lymphocytes into Ig secreting (plasma) cells in response to PWM and SAC, conversion of high-mannose to complex N-linked glycans is essential [2].

Chemical compound and disease context of SAC


Biological context of SAC


Anatomical context of SAC

  • The addition of gamma-IFN together with IL 2 induced IgM and IgG secretion in SAC-stimulated B cells that was comparable with that induced by a conventional T cell factor(s) [18].
  • Induction of germ-line transcripts (germ-line C gamma 1 transcript) was noted in stimulated B cells (SAC plus IL-2) at 6 h; thus, the appearance of germ-line transcripts could not be attributed to preferential growth of B cells expressing germ-line transcripts [19].
  • Vesicles containing DHE traversed the cells in both directions, but vesicular export of DHE from the SAC/ARC to the plasma membrane domains was low [20].
  • In this review, we will focus on the potential subcompartmentalization of the SAC in terms of regulation of membrane traffic, on how SAC relates to the endosomal system, and on how this compartment may operate in the context of other intracellular sorting organelles such as the Golgi complex, in generating and maintaining cell polarity [21].
  • Next to the trans Golgi network, a subapical compartment called SAC or common endosome appears instrumental in regulating these sorting events [22].

Associations of SAC with chemical compounds


Physical interactions of SAC

  • Fluorescent transferrin was found to be transported sequentially through basolateral SE (sorting endosomes) to a SAC/ARC (subapical compartment/apical recycling compartment) [26].

Regulatory relationships of SAC


Other interactions of SAC


Analytical, diagnostic and therapeutic context of SAC

  • Cortical actin assembly played a role in regulating the activity of stretch-activated, calcium-permeable channels (SAC) since sustained force application desensitized SAC to subsequent force applications, and the decrease in stretch sensitivity was reversed after treatment with cytochalasin D [32].
  • PWM was used for T cell-dependent B cell stimulation in an allogeneic coculture system, and SAC I for T cell- and monocyte-independent B cell stimulation [33].
  • The concentrate obtained from ultrafiltration (greater than 30,000 molecular weight) of SAC (1 N NaOH for 24 hr) retained the stimulatory factor [16].
  • RESULTS: Eight patients (four in the SAC group and four in LAC group) could not continue therapy because of severe diarrhoea, and three did not take the 13C urea breath test after therapy [34].
  • From its behavior in pulsed field gel electrophoresis, FISH analysis of stretched DNA fibers, and its appearance under scanning confocal microscopy, it was concluded that the SAC is a circularized and multimerized derivative of the original YAC [35].


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