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MeSH Review

Ear Diseases

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Disease relevance of Ear Diseases


High impact information on Ear Diseases

  • Self-curing controlled release systems for steroids. Application of prednisolone-based polymeric systems to ear diseases [6].
  • OBJECTIVES/HYPOTHESIS: Brain herniation and cerebrospinal fluid (CSF) leakage into the middle ear and mastoid are rare but described complications of chronic ear disease [7].
  • CONCLUSIONS: Brain herniation and/or CSF leak appear to be rare complications of surgery for revision chronic ear disease [7].
  • A number of authors have suggested that oral contraceptives may increase the risk of certain ear diseases, especially otosclerosis and vestibular disorders, although the amount of published information on this topic is limited [8].
  • CONCLUSIONS: The authors conclude that chronic pathologic changes resembling human ear disorders persist and that this model further extends the hypothesis that prenatally acquired keratin eventually could account for some cases of human ear disease [9].

Chemical compound and disease context of Ear Diseases


Anatomical context of Ear Diseases


Gene context of Ear Diseases

  • These data showed that the risk of ear disease in CF was not increased even if patients with severe audiological involvement were described only in the CF group [16].
  • In this second in a series of famous historic personages who suffered from ear disease (see Yardley M, Rutka J. Troy, Mycenae, and the Otologic Demise of Herr Heinrich Schliemann. J Otolaryngol 1998; 27:217-221), we review the life and otology-related death of the legendary playwright Oscar Wilde [17].
  • Topical aminoglycosides? Yes. The case for using these agents in chronic ear disease [18].
  • Eleven subjects with no history of ear disease were subjected to continuous, 24-h, direct ME pressure measurements and tubal function tests, respectively [19].
  • The sera from 21 age- and sex-matched individuals without a history of ear disease served as the control [20].

Analytical, diagnostic and therapeutic context of Ear Diseases


  1. The effects of a single, intravenous dose of bumetanide versus furosemide in patients with ascites and edema due to alcoholic liver disease. Koff, R.S. Journal of clinical pharmacology. (1981) [Pubmed]
  2. The histological effects on the guinea pig external ear of several constituents of commonly used aural preparations. Monkhouse, W.S., Moran, P., Freedman, A. Clinical otolaryngology and allied sciences. (1988) [Pubmed]
  3. Otolaryngologic manifestations of Kabuki syndrome. Peterson-Falzone, S.J., Golabi, M., Lalwani, A.K. Int. J. Pediatr. Otorhinolaryngol. (1997) [Pubmed]
  4. Ethyl apovincaminate in the treatment of sensorineural impairment of hearing. Ribári, O., Zelen, B., Kollár, B. Arzneimittel-Forschung. (1976) [Pubmed]
  5. The ageing ear. A clinico-pathological classification. Belal, A., Glorig, A. The Journal of laryngology and otology. (1987) [Pubmed]
  6. Self-curing controlled release systems for steroids. Application of prednisolone-based polymeric systems to ear diseases. Fernandez, M., Parra, J., Vazquez, B., Lopez-Bravo, A., Román, J.S. Biomaterials (2005) [Pubmed]
  7. Management of brain herniation and cerebrospinal fluid leak in revision chronic ear surgery. Wootten, C.T., Kaylie, D.M., Warren, F.M., Jackson, C.G. Laryngoscope (2005) [Pubmed]
  8. Oral contraception and ear disease: findings in a large cohort study. Vessey, M., Painter, R. Contraception. (2001) [Pubmed]
  9. Juvenile keratin inoculation induces chronic ear pathology. Camacho, A.E., Eavey, R.D., Northrop, C. The American journal of otology. (1997) [Pubmed]
  10. Ciprofloxacin for the treatment of chronic ear disease. Piccirillo, J.F., Parnes, S.M. Laryngoscope (1989) [Pubmed]
  11. Practical versus theoretical management of autoimmune inner ear disease. Hughes, G.B., Kinney, S.E., Barna, B.P., Calabrese, L.H. Laryngoscope (1984) [Pubmed]
  12. Treatment of chronic ear disease. Topical ciprofloxacin vs topical gentamicin. Tutkun, A., Ozagar, A., Koç, A., Batman, C., Uneri, C., Sehitoglu, M.A. Arch. Otolaryngol. Head Neck Surg. (1995) [Pubmed]
  13. Type II collagen-induced autoimmune ear disease in mice: a preliminary report on an epitope of the type II collagen molecule that induced inner ear lesions. Takeda, T., Sudo, N., Kitano, H., Yoo, T.J. The American journal of otology. (1996) [Pubmed]
  14. Surface temperature distributions in carbon dioxide, argon, and KTP (Nd:YAG) laser ablated otic capsule and calvarial bone. Wong, B.J., Neev, J., van Gemert, M.J. The American journal of otology. (1997) [Pubmed]
  15. Mini-craniotomy for management of CSF otorrhea from tegmen defects. Adkins, W.Y., Osguthorpe, J.D. Laryngoscope (1983) [Pubmed]
  16. Ear disease is not a common complication in cystic fibrosis. Cipolli, M., Canciani, M., Cavazzani, M., Uras, P., Zampieri, P., Mastella, G. Eur. J. Pediatr. (1993) [Pubmed]
  17. The irony of being Oscar: the legendary life and death of Oscar Wilde. Mai, R., Rutka, J. The Journal of otolaryngology. (2000) [Pubmed]
  18. Topical aminoglycosides? Yes. The case for using these agents in chronic ear disease. Haynes, D.S. Ear, nose, & throat journal. (2003) [Pubmed]
  19. Middle ear pressure: effect of body position and sleep. Tideholm, B., Brattmo, M., Carlborg, B. Acta Otolaryngol. (1999) [Pubmed]
  20. Ménière's disease and antibody reactivity to herpes simplex virus type 1 polypeptides. Bergström, T., Edström, S., Tjellström, A., Vahlne, A. American journal of otolaryngology. (1992) [Pubmed]
  21. Cochlear implantation in a patient with Cogan's syndrome, chronic ear disease and on steroid therapy. Low, W.K., Burgess, R., Teoh, C.K. Adv. Otorhinolaryngol. (2000) [Pubmed]
  22. A long-term study on hearing status in patients with nasopharyngeal carcinoma after radiotherapy. Wang, L.F., Kuo, W.R., Ho, K.Y., Lee, K.W., Lin, C.S. Otol. Neurotol. (2004) [Pubmed]
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