Disease relevance of Ear Diseases

• A 15-decibel unilateral high-frequency hearing loss was observed following bumetanide treatment in one patient with prior evidence of ear disease [1].
• Contact dermatitis to benzalkonium chloride may be important in persistent ear disease [2].
• A review of clinical findings in 12 children with Kabuki syndrome revealed a high prevalence of otolaryngologic problems, including dysmorphic pinnae (100%), ear disease (92%), hearing loss (82%) and airway problems (58%) [3].
• Ethyl apovincaminate (EGH-4405, Cavinton) treatment has been used in various sensorineural impairments of hearing as well as in ear diseases associated with vertigo [4].
• Hearing impairments that are rapidly progressive, profound, asymmetrical, or fluctuating, and those associated with a marked conductive element or severe dizziness might well be associated with specific ear disease (Nosoacusis) such as infection, otosclerosis, Menière's disease, or acoustic tumor [5].

High impact information on Ear Diseases

• Self-curing controlled release systems for steroids. Application of prednisolone-based polymeric systems to ear diseases [6].
• OBJECTIVES/HYPOTHESIS: Brain herniation and cerebrospinal fluid (CSF) leakage into the middle ear and mastoid are rare but described complications of chronic ear disease [7].
• CONCLUSIONS: Brain herniation and/or CSF leak appear to be rare complications of surgery for revision chronic ear disease [7].
• A number of authors have suggested that oral contraceptives may increase the risk of certain ear diseases, especially otosclerosis and vestibular disorders, although the amount of published information on this topic is limited [8].
• CONCLUSIONS: The authors conclude that chronic pathologic changes resembling human ear disorders persist and that this model further extends the hypothesis that prenatally acquired keratin eventually could account for some cases of human ear disease [9].

Chemical compound and disease context of Ear Diseases

• Ciprofloxacin for the treatment of chronic ear disease [10].
• Flare-ups of autoimmune ear disease are best managed by increasing steroid dosage or adding cytotoxic medications [11].
• Treatment of chronic ear disease. Topical ciprofloxacin vs topical gentamicin [12].
• To identify the epitope on the type II collagen molecule that induced autoimmune ear disease, electrophysiological and histological studies were carried out in DBA/1J mice immunized with native chick type II collagen (Clln) and cyanogen bromide (CNBr) peptide 1I (CB-I1 peptide) that was cleaved from chicken type II collagen with CNBr digestion [13].
• OBJECTIVE: To determine and compare the therapeutic efficiency of ciprofloxacin hydrochloride and gentamicin sulfate in the treatment of chronic ear disease [12].

Anatomical context of Ear Diseases

• BACKGROUND: Carbon dioxide (CO2) (lambda = 10.6 mm), argon (lambda = 514 nm), and Potassium-Titanyl-Phosphate Neodynium: Yttrium-Aluminum-Garnet (KTP[Nd:YAG]) (lambda = 532 nm) lasers are used for stapes surgery and in the treatment of chronic ear disease [14].
• In the six cases presented, the tegmen defect and associated CSF leak were secondary to chronic ear disease in two cases, to mastoid surgery in two cases, to temporal bone fracture and congenital origin in one case each [15].

Gene context of Ear Diseases

• These data showed that the risk of ear disease in CF was not increased even if patients with severe audiological involvement were described only in the CF group [16].
• In this second in a series of famous historic personages who suffered from ear disease (see Yardley M, Rutka J. Troy, Mycenae, and the Otologic Demise of Herr Heinrich Schliemann. J Otolaryngol 1998; 27:217-221), we review the life and otology-related death of the legendary playwright Oscar Wilde [17].
• Topical aminoglycosides? Yes. The case for using these agents in chronic ear disease [18].
• Eleven subjects with no history of ear disease were subjected to continuous, 24-h, direct ME pressure measurements and tubal function tests, respectively [19].
• The sera from 21 age- and sex-matched individuals without a history of ear disease served as the control [20].

Analytical, diagnostic and therapeutic context of Ear Diseases

• Cochlear implantation in a patient with Cogan's syndrome, chronic ear disease and on steroid therapy [21].
• The patient had to have had at least 12 months of audiologic follow-up, no concurrent chronic ear disease, no direct tumor invasion of ear, and no significant sensorineural hearing loss before radiotherapy [22].

References