Gene Review:
GM2A - GM2 ganglioside activator
Homo sapiens
Synonyms:
Cerebroside sulfate activator protein, GM2-AP, Ganglioside GM2 activator, SAP-3, Sphingolipid activator protein 3
Kalkanci,
Bozdayi,
Biri,
Kustimur,
Whitelegge,
Ahn,
Norris,
Sung,
Waring,
Stevens,
Fluharty,
Prive,
Faull,
Fluharty,
Grams,
Adisakwattana,
Ritthisunthorn,
Eursitthichai,
Vichasri-Grams,
Viyanant,
- The GM2 gangliosidoses databases: allelic variation at the HEXA, HEXB, and GM2A gene loci. Cordeiro, P., Hechtman, P., Kaplan, F. Genet. Med. (2000)
- Refined mapping of the GM2 activator protein (GM2A) locus to 5q31.3-q33.1, distal to the spinal muscular atrophy locus. Heng, H.H., Xie, B., Shi, X.M., Tsui, L.C., Mahuran, D.J. Genomics (1993)
- Characterization of an alternatively spliced GM2 activator protein, GM2A protein. An activator protein which stimulates the enzymatic hydrolysis of N-acetylneuraminic acid, but not N-acetylgalactosamine, from GM2. Wu, Y.Y., Sonnino, S., Li, Y.T., Li, S.C. J. Biol. Chem. (1996)
- In vivo analysis of secreted aspartyl proteinase expression in human oral candidiasis. Naglik, J.R., Newport, G., White, T.C., Fernandes-Naglik, L.L., Greenspan, J.S., Greenspan, D., Sweet, S.P., Challacombe, S.J., Agabian, N. Infect. Immun. (1999)
- Effect of GM2 activator protein on the enzymatic hydrolysis of phospholipids and sphingomyelin. Shimada, Y., Li, Y.T., Li, S.C. J. Lipid Res. (2003)
- The lysosomal trafficking of sphingolipid activator proteins (SAPs) is mediated by sortilin. Lefrancois, S., Zeng, J., Hassan, A.J., Canuel, M., Morales, C.R. EMBO J. (2003)
- Molecular analysis of a GM2-activator deficiency in two patients with GM2-gangliosidosis AB variant. Schepers, U., Glombitza, G., Lemm, T., Hoffmann, A., Chabas, A., Ozand, P., Sandhoff, K. Am. J. Hum. Genet. (1996)
- Characterization of a recombinant molecule covalently indistinguishable from human cerebroside-sulfate activator protein (CSAct or Saposin B). Whitelegge, J.P., Ahn, V., Norris, A.J., Sung, H., Waring, A., Stevens, R.L., Fluharty, C.B., Prive, G., Faull, K.F., Fluharty, A.L. Cell. Mol. Biol. (Noisy-le-grand) (2003)
- The complete amino-acid sequences of human ganglioside GM2 activator protein and cerebroside sulfate activator protein. Fürst, W., Schubert, J., Machleidt, W., Meyer, H.E., Sandhoff, K. Eur. J. Biochem. (1990)
- The saposin-like proteins 1, 2, and 3 of Fasciola gigantica. Grams, R., Adisakwattana, P., Ritthisunthorn, N., Eursitthichai, V., Vichasri-Grams, S., Viyanant, V. Mol. Biochem. Parasitol. (2006)
- Photoaffinity labelling of the human GM2-activator protein. Mechanistic insight into ganglioside GM2 degradation. Wendeler, M., Hoernschemeyer, J., Hoffmann, D., Kolter, T., Schwarzmann, G., Sandhoff, K. Eur. J. Biochem. (2004)
- Differential expression of secreted aspartyl proteinases in a model of human oral candidosis and in patient samples from the oral cavity. Schaller, M., Schäfer, W., Korting, H.C., Hube, B. Mol. Microbiol. (1998)
- Crystal structure of human GM2-activator protein with a novel beta-cup topology. Wright, C.S., Li, S.C., Rastinejad, F. J. Mol. Biol. (2000)
- Candida albicans hyphal formation and the expression of the Efg1-regulated proteinases Sap4 to Sap6 are required for the invasion of parenchymal organs. Felk, A., Kretschmar, M., Albrecht, A., Schaller, M., Beinhauer, S., Nichterlein, T., Sanglard, D., Korting, H.C., Schäfer, W., Hube, B. Infect. Immun. (2002)
- Evidence for lipid packaging in the crystal structure of the GM2-activator complex with platelet activating factor. Wright, C.S., Mi, L.Z., Rastinejad, F. J. Mol. Biol. (2004)
- The sorting and trafficking of lysosomal proteins. Ni, X., Canuel, M., Morales, C.R. Histol. Histopathol. (2006)
- Study of interaction of GM2 activator protein with GM2 using circular dichroism and fluorescence spectroscopy. Ravasi, D., Masserini, M., Vecchio, G., Li, Y.T., Li, S.C. Neurochem. Res. (2002)
- Distribution of secreted aspartyl proteinases using a polymerase chain reaction assay with SAP specific primers in Candida albicans isolates. Kalkanci, A., Bozdayi, G., Biri, A., Kustimur, S. Folia Microbiol. (Praha) (2005)
- Reduced expression of the hyphal-independent Candida albicans proteinase genes SAP1 and SAP3 in the efg1 mutant is associated with attenuated virulence during infection of oral epithelium. Korting, H.C., Hube, B., Oberbauer, S., Januschke, E., Hamm, G., Albrecht, A., Borelli, C., Schaller, M. J. Med. Microbiol. (2003)
- Structure of the GM2A gene: identification of an exon 2 nonsense mutation and a naturally occurring transcript with an in-frame deletion of exon 2. Chen, B., Rigat, B., Curry, C., Mahuran, D.J. Am. J. Hum. Genet. (1999)
- Expression of the GM2-activator protein in the methylotrophic yeast Pichia pastoris, purification, isotopic labeling, and biophysical characterization. Wendeler, M., Hoernschemeyer, J., John, M., Werth, N., Schoeniger, M., Lemm, T., Hartmann, R., Kessler, H., Sandhoff, K. Protein Expr. Purif. (2004)