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Gene Review

Spg21  -  spastic paraplegia 21 homolog (human)

Mus musculus

Synonyms: ACP33, Acid cluster protein 33, BM-019, C78576, D9Wsu18e, ...
 
 
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Disease relevance of Spg21

 

High impact information on Spg21

  • These subsets were isolated using magnetic and fluorescence-activated cell sorting, phenotypically analyzed, and tested in vitro for cobblestone area-forming cells (CAFC) and colony-forming units in culture (CFU-C; M/G/E/Meg/Mast) [6].
  • Several lines of evidence indicated that the 125I-fibrin deposition associated with the PCA reactions was dependent on the activity of mast cells: 1) Mast cell degranulation occurred at sites of PCA reactions [7].
  • The most diverse type of mixed colony contained macrophages (m), neutrophils (n), eosinophils (e), mast cells (Mast), megakaryocytes (M), erythroid cells (E), and blast cells [8].
  • METHODS: Mast cell-deficient mice (WBB6F1-W/Wv) and their congenic normal littermates (WBB6F1-+/+) were immunized with ovalbumin and challenged by inhalation with the relevant antigen [9].
  • CONCLUSIONS: Mast cells and VEGF are central to the formation of postoperative intra-abdominal adhesions with mast cells being responsible, either directly or indirectly, for VEGF release into the peritoneal cavity after operation [10].
 

Biological context of Spg21

 

Anatomical context of Spg21

  • PURPOSE: Mast cell and neutrophil degranulations are the important players in inflammatory disorders [12].
  • BACKGROUND: Mast cells are widely distributed in the gastrointestinal mucosa [13].
  • This result confirms our earlier data on the depletion of lymphatic Mast Cells in the lymph nodes stimulated by various antigens [14].
 

Associations of Spg21 with chemical compounds

  • METHODS: Mast cell-deficient W/Wv and their normal littermate +/+ mice were given intrarectal administration of 5% acetic acid [13].

References

  1. Differential brain transcriptome of beta4 nAChR subunit-deficient mice: is it the effect of the null mutation or the background strain? Kedmi, M., Orr-Urtreger, A. Physiol. Genomics (2007) [Pubmed]
  2. Comment on "Mast cell-mediated remodeling and fibrinolytic activity protect against fatal glomerulonephritis". Hochegger, K., Rosenkranz, A.R., Siebenhaar, F., Maurer, M. J. Immunol. (2006) [Pubmed]
  3. [125I]fibrin deposition occurs at both early and late intervals of IgE-dependent or contact sensitivity reactions elicited in mouse skin. Mast cell-dependent augmentation of fibrin deposition at early intervals in combined IgE-dependent and contact sensitivity reactions. Mekori, Y.A., Galli, S.J. J. Immunol. (1990) [Pubmed]
  4. Chronic graft-versus-host disease as a model for scleroderma. II. Mast cell depletion with deposition of immunoglobulins in the skin and fibrosis. Claman, H.N., Jaffee, B.D., Huff, J.C., Clark, R.A. Cell. Immunol. (1985) [Pubmed]
  5. Critical role of mast cells in morphine-mediated impairment of zymosan-induced peritonitis in mice. Kolaczkowska, E., Seljelid, R., Plytycz, B. Inflamm. Res. (2001) [Pubmed]
  6. Identification of hematopoietic stem cell subsets on the basis of their primitiveness using antibody ER-MP12. van der Loo, J.C., Slieker, W.A., Kieboom, D., Ploemacher, R.E. Blood (1995) [Pubmed]
  7. 125I-fibrin deposition in IgE-dependent immediate hypersensitivity reactions in mouse skin. Demonstration of the role of mast cells using genetically mast cell-deficient mice locally reconstituted with cultured mast cells. Wershil, B.K., Mekori, Y.A., Murakami, T., Galli, S.J. J. Immunol. (1987) [Pubmed]
  8. Analysis of pure and mixed murine mast cell colonies. Pharr, P.N., Suda, T., Bergmann, K.L., Avila, L.A., Ogawa, M. J. Cell. Physiol. (1984) [Pubmed]
  9. Transient contribution of mast cells to pulmonary eosinophilia but not to hyper-responsiveness. Ogawa, K., Kaminuma, O., Kikkawa, H., Nakata, A., Asahina, M., Egan, R.W., Akiyama, K., Mori, A. Clin. Exp. Allergy (2002) [Pubmed]
  10. Mast cells facilitate local VEGF release as an early event in the pathogenesis of postoperative peritoneal adhesions. Cahill, R.A., Wang, J.H., Soohkai, S., Redmond, H.P. Surgery (2006) [Pubmed]
  11. Images in allergy and immunology. Mast cell apoptosis. Dvorak, A.M. Int. Arch. Allergy Immunol. (1999) [Pubmed]
  12. Synthesis and anti-inflammatory effect of chalcones and related compounds. Hsieh, H.K., Lee, T.H., Wang, J.P., Wang, J.J., Lin, C.N. Pharm. Res. (1998) [Pubmed]
  13. Evaluation of the role of mast cells in the progression of acetic acid-induced colitis in mice. Higa, A., Ishikawa, N., Eto, T., Nawa, Y. Scand. J. Gastroenterol. (1996) [Pubmed]
  14. Decrease of lymphatic mast cells in response to syngeneic WAMIB tumor cells. Włodarski, K., Rychlik, G., Mazur, S., Dołowy, J., Jakóbisiak, M. Arch. Immunol. Ther. Exp. (Warsz.) (1985) [Pubmed]
 
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