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Gene Review

LUM  -  lumican

Bos taurus

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Disease relevance of LUM


High impact information on LUM


Chemical compound and disease context of LUM

  • These results suggest that corneas with keratoconus contain a form of KSPG that contains fewer keratan sulfate chains or in which the keratan sulfate has a modified structure [2].

Biological context of LUM


Anatomical context of LUM


Associations of LUM with chemical compounds

  • About two-thirds of the lumican protein consists of a series of 10 amino acid leucine-rich repeats that occur in regions of calculated high beta-hydrophobic moment, suggesting that the leucine-rich repeats contribute to beta-sheet formation in these proteins [6].
  • Location of 6 cysteine and 4 consensus N-glycosylation sites in the bovine sequence were identical to those in chicken lumican [6].
  • Cells in control corneas synthesized both a chondroitin sulfate proteoglycan and a keratan sulfate proteoglycan similar to those present in monkey and bovine corneas [1].
  • Treatment of arterial lumican with endo-beta-galactosidase released 8-9 mol of glucosamine and galactose per mol of protein as oligosaccharides [14].
  • These results show that cultured bovine keratocytes maintain the ability to express all three of the known KSPG proteins, modified with keratan sulfate chains and sulfated on both N-acetylglucosamine and galactose moieties [15].

Physical interactions of LUM


Other interactions of LUM


Analytical, diagnostic and therapeutic context of LUM


  1. Macular corneal dystrophy: failure to synthesize a mature keratan sulfate proteoglycan. Hassell, J.R., Newsome, D.A., Krachmer, J.H., Rodrigues, M.M. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  2. Altered keratan sulfate epitopes in keratoconus. Funderburgh, J.L., Panjwani, N., Conrad, G.W., Baum, J. Invest. Ophthalmol. Vis. Sci. (1989) [Pubmed]
  3. Studies on the hemagglutinant activity of some Aeromonas strains. Israil, A., Nacescu, N., Cedru, C. Roumanian archives of microbiology and immunology. (1993) [Pubmed]
  4. Bone matrix proteins: isolation and characterization of a novel cell-binding keratan sulfate proteoglycan (osteoadherin) from bovine bone. Wendel, M., Sommarin, Y., Heinegård, D. J. Cell Biol. (1998) [Pubmed]
  5. Fibroblast growth factor-2 promotes keratan sulfate proteoglycan expression by keratocytes in vitro. Long, C.J., Roth, M.R., Tasheva, E.S., Funderburgh, M., Smit, R., Conrad, G.W., Funderburgh, J.L. J. Biol. Chem. (2000) [Pubmed]
  6. Sequence and structural implications of a bovine corneal keratan sulfate proteoglycan core protein. Protein 37B represents bovine lumican and proteins 37A and 25 are unique. Funderburgh, J.L., Funderburgh, M.L., Brown, S.J., Vergnes, J.P., Hassell, J.R., Mann, M.M., Conrad, G.W. J. Biol. Chem. (1993) [Pubmed]
  7. Unique glycosylation of three keratan sulfate proteoglycan isoforms. Funderburgh, J.L., Funderburgh, M.L., Mann, M.M., Conrad, G.W. J. Biol. Chem. (1991) [Pubmed]
  8. Downregulation of microglial keratan sulfate proteoglycans coincident with lymphomonocytic infiltration of the rat central nervous system. Jander, S., Stoll, G. Am. J. Pathol. (1996) [Pubmed]
  9. Molecular cloning and tissue distribution of keratocan. Bovine corneal keratan sulfate proteoglycan 37A. Corpuz, L.M., Funderburgh, J.L., Funderburgh, M.L., Bottomley, G.S., Prakash, S., Conrad, G.W. J. Biol. Chem. (1996) [Pubmed]
  10. The primary structure of a basic leucine-rich repeat protein, PRELP, found in connective tissues. Bengtsson, E., Neame, P.J., Heinegård, D., Sommarin, Y. J. Biol. Chem. (1995) [Pubmed]
  11. Changes in leucine-rich repeat proteoglycans during maturation of the bovine growth plate. Alini, M., Roughley, P.J. Matrix Biol. (2001) [Pubmed]
  12. Differential distribution of lumican and fibromodulin in tooth cementum. Cheng, H., Caterson, B., Neame, P.J., Lester, G.E., Yamauchi, M. Connect. Tissue Res. (1996) [Pubmed]
  13. Conformation, stability and interactions of corneal keratan sulfate proteoglycan. Uma, L., Sharma, Y., Balasubramanian, D. Biochim. Biophys. Acta (1996) [Pubmed]
  14. Arterial lumican. Properties of a corneal-type keratan sulfate proteoglycan from bovine aorta. Funderburgh, J.L., Funderburgh, M.L., Mann, M.M., Conrad, G.W. J. Biol. Chem. (1991) [Pubmed]
  15. Synthesis of corneal keratan sulfate proteoglycans by bovine keratocytes in vitro. Funderburgh, J.L., Funderburgh, M.L., Mann, M.M., Prakash, S., Conrad, G.W. J. Biol. Chem. (1996) [Pubmed]
  16. Tissue distribution of a novel cell binding protein, osteoadherin, in the rat. Shen, Z., Gantcheva, S., Sommarin, Y., Heinegård, D. Matrix Biol. (1999) [Pubmed]
  17. Mimecan, the 25-kDa corneal keratan sulfate proteoglycan, is a product of the gene producing osteoglycin. Funderburgh, J.L., Corpuz, L.M., Roth, M.R., Funderburgh, M.L., Tasheva, E.S., Conrad, G.W. J. Biol. Chem. (1997) [Pubmed]
  18. Binding of fibromodulin and decorin to separate sites on fibrillar collagens. Hedbom, E., Heinegård, D. J. Biol. Chem. (1993) [Pubmed]
  19. Resistance of small leucine-rich repeat proteoglycans to proteolytic degradation during interleukin-1-stimulated cartilage catabolism. Sztrolovics, R., White, R.J., Poole, A.R., Mort, J.S., Roughley, P.J. Biochem. J. (1999) [Pubmed]
  20. Distribution of proteoglycans antigenically related to corneal keratan sulfate proteoglycan. Funderburgh, J.L., Caterson, B., Conrad, G.W. J. Biol. Chem. (1987) [Pubmed]
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