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Gene Review

Blmh  -  bleomycin hydrolase

Rattus norvegicus

Synonyms: BH, BLM hydrolase, BMH, Bleomycin hydrolase
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High impact information on Blmh

  • The DTT-dependent activation was inhibited by 1,6-bis(maleimido)hexane (BMH) but not by N-ethylmaleimide, indicating that cross-linking between cysteine residues in UGT1A6 is responsible for the activation [1].
  • Replacement of either Cys 121 or Cys 125 with serine showed insensitivity to the BMH-dependent inhibition [1].
  • Treatment of COS microsomes with DTT had no effect on the activity of the wild type but BMH showed significant inhibition, suggesting that UGT1A6 expressed in COS cells may be in the reduced and activated state [1].
  • Apo BH mRNA editing is both tissue-specific and hormonally regulated and involves transition of cytidine to uridine at codon 2153 thereby converting a glutamine codon (CAA) to a translational stop codon (UAA) [2].
  • Cloning and analysis of cDNA encoding rat bleomycin hydrolase, a DNA-binding cysteine protease [3].

Biological context of Blmh


Anatomical context of Blmh


Analytical, diagnostic and therapeutic context of Blmh

  • The cDNA encoded a polypeptide composed of 454 amino acids, that had a slightly larger molecular mass than that was previously estimated by SDS-PAGE for purified BLM hydrolase subunit [3].
  • Western blotting and immunohistochemical analyses showed that BLM hydrolase is ubiquitous in various rat tissues but at low levels in lung and adult skin tissues, suggesting that this enzyme plays an important role in the metabolism of antibiotics [4].


  1. Activation of glucuronidation through reduction of a disulfide bond in rat UDP-glucuronosyltransferase 1A6. Ikushiro, S., Emi, Y., Iyanagi, T. Biochemistry (2002) [Pubmed]
  2. Quantitation of endogenous liver apolipoprotein B mRNA editing. Backus, J.W., Eagleton, M.J., Harris, S.G., Sparks, C.E., Sparks, J.D., Smith, H.C. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
  3. Cloning and analysis of cDNA encoding rat bleomycin hydrolase, a DNA-binding cysteine protease. Takeda, A., Masuda, Y., Yamamoto, T., Hirabayashi, T., Nakamura, Y., Nakaya, K. J. Biochem. (1996) [Pubmed]
  4. Purification and characterization of bleomycin hydrolase, which represents a new family of cysteine proteases, from rat skin. Takeda, A., Higuchi, D., Yamamoto, T., Nakamura, Y., Masuda, Y., Hirabayashi, T., Nakaya, K. J. Biochem. (1996) [Pubmed]
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