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Gene Review

Blmh  -  bleomycin hydrolase

Mus musculus

Synonyms: AI035728, BH, BLM hydrolase, BMH, Bh, ...
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Disease relevance of Blmh


High impact information on Blmh


Chemical compound and disease context of Blmh


Anatomical context of Blmh

  • BMH tumor cells injected into syngeneic newborn as well as young adult hamsters produced tumors at the site of application and metastasized frequently into viscera [4].
  • From hamster tumors five stable tumor cell lines (BMH/1--BMH/5) were established in vitro [4].

Analytical, diagnostic and therapeutic context of Blmh


  1. The neutral cysteine protease bleomycin hydrolase is essential for epidermal integrity and bleomycin resistance. Schwartz, D.R., Homanics, G.E., Hoyt, D.G., Klein, E., Abernethy, J., Lazo, J.S. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  2. Purification of bleomycin hydrolase with a monoclonal antibody and its characterization. Nishimura, C., Tanaka, N., Suzuki, H., Tanaka, N. Biochemistry (1987) [Pubmed]
  3. Potentiation of the cytotoxicity of peplomycin against Ehrlich ascites carcinoma by bleomycin hydrolase inhibitors. Nishimura, C., Nishimura, T., Tanaka, N., Suzuki, H. J. Antibiot. (1987) [Pubmed]
  4. Metastasizing fibrosarcomas in hamsters (BMH) after injection of B77 sarcoma virus transformed mouse cells. Sabová, L., Smida, J., Smidová, V. Neoplasma (1983) [Pubmed]
  5. Biological effects of Veillonella parvula and Bacteroides intermedius lipopolysaccharides. Matera, G., Liberto, M.C., Berlinghieri, M.C., Focà, A. Microbiologica (1991) [Pubmed]
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